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Surgery Today
Published in: Surgery Today 6/2015

01-06-2015 | Original Article

Protein kinase Cι is a new prognostic factor in gastric cancer

Authors: Hideya Kashihara, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Hirohiko Sato, Kozo Yoshikawa, Tomohiko Miyatani, Chie Takasu, Noriko Matsumoto

Published in: Surgery Today | Issue 6/2015

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Abstract

Purposes

Protein kinase Cι (PKCι) is an important oncogenic K-ras effector, and its expression is correlated with tumor angiogenesis. The role of PKCι in gastric cancer remains unclear. The aim of this study was to clarify the role of PKCι in gastric cancer.

Methods

Twenty-eight patients with gastric cancer who underwent gastrectomy were enrolled in this study. The expression of PKCι mRNA was determined, as were the clinicopathological factors. The patients were divided into PKCι high and low expression groups. The 5-year survival rate, ERK mRNA level and VEGF mRNA level were compared between the two groups. The prognostic factors were investigated by a multivariate analysis.

Results

High expression of PKCι was observed to be associated with a lack of differentiation, tumor invasion ≥muscularis propria≤, stage III and IV disease and peritoneal dissemination. The 5-year survival rate in the PKCι high group was lower than that in the PKCι low group. The multivariate analysis revealed that a high expression level of PKCι was an independent prognostic factor. The expression levels of ERK and VEGF in the PKCι high group were higher than those in the PKCι low group.

Conclusion

Our results indicate that PKCι is correlated with tumor progression and angiogenesis. PKCι may be a new prognostic factor for gastric cancer.
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Metadata
Title
Protein kinase Cι is a new prognostic factor in gastric cancer
Authors
Hideya Kashihara
Mitsuo Shimada
Nobuhiro Kurita
Takashi Iwata
Hirohiko Sato
Kozo Yoshikawa
Tomohiko Miyatani
Chie Takasu
Noriko Matsumoto
Publication date
01-06-2015
Publisher
Springer Japan
Published in
Surgery Today / Issue 6/2015
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-014-1010-5

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