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Critical Care
Published in: Critical Care 5/2010

01-10-2010 | Letter

Protective role of statins against ventilator-induced lung injury

Authors: Ilias I Siempos, Petros Kopterides, Nikolaos A Maniatis, Apostolos Armaganidis

Published in: Critical Care | Issue 5/2010

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Excerpt

We compliment Dr Müller and colleagues [1] for their experiment on the protective role of simvastatin against ventilator-induced lung injury (VILI). Their results are in line with those of a relevant study published recently by our research team; we also showed that pretreatment with statins (specifically atorvastatin) attenuates VILI [2]. By synthesizing the findings of the above contributions [1, 2], one could make several points. …
Literature
1.
Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M: Simvastatin attenuates ventilator-induced lung injury in mice. Crit Care 2010, 14: R143. 10.1186/cc9209PubMedCentralCrossRefPubMed
2.
Siempos II, Maniatis NA, Kopterides P, Magkou C, Glynos C, Roussos C, Armaganidis A: Pretreatment with atorvastatin attenuates lung injury caused by high-stretch mechanical ventilation in an isolated rabbit lung model. Crit Care Med 2010, 38: 1321-1328.PubMed
3.
Putting gender on the agenda Nature 2010, 465: 665.
Metadata
Title
Protective role of statins against ventilator-induced lung injury
Authors
Ilias I Siempos
Petros Kopterides
Nikolaos A Maniatis
Apostolos Armaganidis
Publication date
01-10-2010
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2010
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9245

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