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Journal of Orthopaedic Surgery and Research

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Open Access 01-12-2024 | Research article

Protective effects of Shensuitongzhi formula on intervertebral disc degeneration via downregulation of NF-κB signaling pathway and inflammatory response

Authors: Xu Wang, Qinghe Zeng, Qinwen Ge, Songfeng Hu, Hongting Jin, Ping-er Wang, Ju Li

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2024

Abstract

Low back pain (LBP) is a common orthopedic disease over the world. Lumbar intervertebral disc degeneration (IDD) is regarded as an important cause of LBP. Shensuitongzhi formula (SSTZF) is a drug used in clinical treatment for orthopedic diseases. It has been found that SSTZF can have a good treatment for IDD. But the exact mechanism has not been clarified. The results showed that SSTZF protects against LSI-induced degeneration of cartilage endplates and intervertebral discs. Meanwhile, SSTZF treatment dramatically reduces the expression of inflammatory factor as well as the expression of catabolism protein and upregulates the expression of anabolism protein in LSI-induced mice. In addition, SSTZF delayed the progression of LSI-induced IDD via downregulation the level of NF-κB signaling key gene RELA and phosphorylation of key protein P65 in endplate chondrocytes. Our study has illustrated the treatment as well as the latent mechanism of SSTZF in IDD.

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Title: Protective effects of Shensuitongzhi formula on intervertebral disc degeneration via downregulation of NF-κB signaling pathway and inflammatory response
Authors: Xu Wang
Qinghe Zeng
Qinwen Ge
Songfeng Hu
Hongting Jin
Ping-er Wang
Ju Li
Publication date: 01-12-2024
Publisher: BioMed Central
Published in: Journal of Orthopaedic Surgery and Research / Issue 1/2024
Electronic ISSN: 1749-799X
DOI: https://doi.org/10.1186/s13018-023-04391-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Protective effects of Shensuitongzhi formula on intervertebral disc degeneration via downregulation of NF-κB signaling pathway and inflammatory response

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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