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Published in: Journal of Robotic Surgery 2/2023

18-06-2022 | Prostate Cancer | Review Article

Impact of human placental derivative allografts on functional and oncological outcomes after radical prostatectomy: a literature review

Authors: Jonathan Noël, Subuhee Ahmed, Anya Mascarenhas, Daniel Stirt, Marcio Moschovas, Ela Patel, Sunil Reddy, Seetharam Bhat, Travis Rogers, Vipul Patel

Published in: Journal of Robotic Surgery | Issue 2/2023

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Abstract

Post radical prostatectomy (RP) erectile dysfunction and incontinence impacts quality of life for patients. In an objective to hasten the recovery of these functional outcomes, human placental derived allografts laid on neurovascular bundles (NVB) have been investigated. These grafts include amniotic membranes (AM) chorionic membranes (CM) or umbilical cord (UC) allografts. A literature review performed using the MeSH terms “AMNION” OR “CHORION” OR “AMNIOTIC MEMBRANE” OR “UMBILICAL CORD” AND “PROSTATE CANCER” from no specified start date, to April 2022. 163 articles were retrieved, with 149 articles excluded. 14 articles were eligible and analysed. 5 articles were included in this review for an analysis on comparative outcomes. The average return to potency was statistically significant in the intervention groups. Positive surgical margin (PSM) rates showed a higher rate in the control groups. BCR was observed at a lower rate in the interventional group. This review reveals a benefit from human placental allograft's ability to hasten post RP functional recovery, without impacting oncological control.
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Metadata
Title
Impact of human placental derivative allografts on functional and oncological outcomes after radical prostatectomy: a literature review
Authors
Jonathan Noël
Subuhee Ahmed
Anya Mascarenhas
Daniel Stirt
Marcio Moschovas
Ela Patel
Sunil Reddy
Seetharam Bhat
Travis Rogers
Vipul Patel
Publication date
18-06-2022
Publisher
Springer London
Published in
Journal of Robotic Surgery / Issue 2/2023
Print ISSN: 1863-2483
Electronic ISSN: 1863-2491
DOI
https://doi.org/10.1007/s11701-022-01433-6

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