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01-07-2021 | Prostate Cancer | Pelvis

Evaluation of MR elastography for prediction of lymph node metastasis in prostate cancer

Authors: Bing Hu, Ying Deng, Jingbiao Chen, Sichi Kuang, Wenjie Tang, Bingjun He, Linqi Zhang, Yuanqiang Xiao, Jun Chen, Phillip Rossman, Arvin Arani, Ziying Yin, Kevin J. Glaser, Meng Yin, Sudhakar K. Venkatesh, Richard L. Ehman, Jin Wang

Published in: Abdominal Radiology | Issue 7/2021

Abstract

Purpose

To assess the relationship between MRE stiffness of prostate cancer (PCa) and the extent of lymph node metastasis (LNM) in patients with PCa undergoing radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND).

Materials

The local institutional review board approved this retrospective study. We retrospectively analyzed 49 patients, who had undergone MRE, mpMRI and pelvic MRI on a 3.0 T MRI scanner, with histopathological confirmed PCa after RP (from June 2015 to December 2019). For each patient, preoperative clinical data and characteristics of MRE, mpMRI and pelvic MRI were recorded. Independent-samples t test, univariate and multivariate logistic regression analyses were performed. And receiver operating characteristic (ROC) analysis were performed to compare the diagnostic performances of multivariate models with the Briganti 2019 nomogram.

Results

PCa MRE stiffness and maximum diameter were independent predictors of LNM. When PCa MRE stiffness at 60 Hz (odds ratio [OR] = 20.223, P = 0.013) and maximum diameter (OR = 4.575, P = 0.046) were combined, the sensitivity and specificity were 100% and 91.9% to predict LNM. When PCa MRE stiffness at 90 Hz (OR = 7.920, P = 0.013) and maximum diameter (OR = 2.810, P = 0.045) were combined, the sensitivity and specificity were 100% and 86.5% to predict LNM. The areas under curves (AUCs) of the combinations were higher than the AUC of the Briganti 2019 nomogram (0.982 vs. 0.904, P = 0.040 [60 Hz]; 0.975 vs. 0.904, P = 0.060 [90 Hz], respectively).

Conclusions

MRE-based assessment of PCa stiffness may be useful for predicting LNM of PCa preoperatively and noninvasively.

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Title: Evaluation of MR elastography for prediction of lymph node metastasis in prostate cancer
Authors: Bing Hu
Ying Deng
Jingbiao Chen
Sichi Kuang
Wenjie Tang
Bingjun He
Linqi Zhang
Yuanqiang Xiao
Jun Chen
Phillip Rossman
Arvin Arani
Ziying Yin
Kevin J. Glaser
Meng Yin
Sudhakar K. Venkatesh
Richard L. Ehman
Jin Wang
Publication date: 01-07-2021
Publisher: Springer US
Keywords: Prostate Cancer
Metastasis
Prostate Cancer
Published in: Abdominal Radiology / Issue 7/2021
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI: https://doi.org/10.1007/s00261-021-02982-4

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