Top

Published in:

01-07-2008 | Case Report

Prospective use of dual-energy X-ray absorptiometry in a model of immobilization and exercise in rats: the preliminary results

Authors: Ayce Atalay, Murat Yildirim, Yesim Gokce-Kutsal, Rustu Onur, Macit Arıyurek

Published in: Rheumatology International | Issue 9/2008

Excerpt

Osteoporosis and fractures due to enhanced fragility of bones resulting from decreased bone mass and deterioration of microarchitecture are among the leading health issues worldwide. Animal studies on the pathogenesis and treatment of osteoporosis often require assessment of bone mineral density (BMD) [1, 2]. Dual-energy X-ray absorptiometry (DXA) is optimal for rats weighing more than 200 g [3]. Rats have open epiphyses and continued capacity for growth; however, most studies have failed to include time 0 controls [4]. …

Gala Paniagua JG, Diaz-Curiel M, de la Piedra Gordo C, Castilla Reparaz C, Torralbo Garcia M (1998) Bone mass assessment in rats by dual energy X-ray absorptiometry. Br J Radiol 71:754–758PubMed

Griffin MG, Kimble R, Hopfer W, Pacifici R (1993) Dual-energy X-ray absorptiometry of the rat: accuracy, precision and measurement of bone loss. J Bone Miner Res 8:795–800PubMedCrossRef

Bertin E, Ruiz JC, Mourot J, Peiniau P, Portha B (1998) Evaluation of dual-energy X-Ray absorptiometry for body-composition assessment in rats. J Nutr 128:1550–1554PubMed

Jee WS, Yao W (2001) Overview: animal models of osteopenia and osteoporosis. J Musculoskelet Neuronal Interact 1:193–207PubMed

Frost HM (2001) The Utah paradigm on animal models of skeletal disorders: quo vadis? J Musculoskelet Neuronal Interact 1:185–191PubMed

Robling AG, Burr DB, Turner CH (2001) Skeletal loading in animals. J Musculoskelet Neuronal Interact 1:249–262PubMed

Yeh JK, Aloia JF, Tierney JM, Sprintz S (1993) Effect of treadmill exercise on vertebral and tibial bone mineral content and bone mineral density in the aged adult rat: determined by dual energy X-ray absorptiometry. Calcif Tissue Int 52:234–238PubMedCrossRef

Norman TL, Bardley-Popovich G, Clovis N, Cutlip RG, Bryner RW (2000) Aerobic exercise as a countermeasure for microgravity-induced bone loss and muscle atrophy in a rat hindlimb suspension model. Aviat Space Environ Med 71:593–598PubMed

Bennell KL, Khan KM, Warmington S, Forwood MR, Coleman BD, Bennett MB, Wark JD (2002) Age does not influence the bone reponse to treadmill exercise in female rats. Med Sci Sports Exerc 34:1958–1965PubMedCrossRef

10.

Soon G, Quintin A, Scalfo F, Antille N, Williamson G, Offord E, Ginty F (2006) PIXImus bone densitometer and associated technical measurement issues of skeletal growth in the young rat. Calcif Tissue Int 78:186–192PubMedCrossRef

11.

Hagiwara S, Lane N, Engelke K, Sebastian A, Kimmel DB, Genant HK (1993) Precision and accuracy for rat whole body and femur bone mineral determination with dual X-ray absorptiometry. Bone Miner 22:57–68PubMedCrossRef

12.

Horton JA, Murray GM, Spadaro JA, Margulies BS, Allen MJ, Damron TA (2003) Precision and accuracy of DXA and pQCT for densitometry of the rat femur. J Clin Densitom 6:381–390PubMedCrossRef

13.

Petersen MM, Nielsen PK, Lewin E, Olgaard K (2000) Dual energy X-ray absorptiometry in small rats with low bone mineral density. Calcif Tissue Int 67:455–459PubMedCrossRef

14.

Pastoureau P, Chomel A, Bonnet J (1995) Specific evaluation of localized bone mass and bone loss in the rat using dual-energy X-ray absorptiometry subregional analysis. Osteoporos Int 5:143–149PubMedCrossRef

15.

Giavaresi G, Borsari V, Fini M, Martini L, Tschon M, De Terlizzi F, Nicolini A, Carpi A, Giardino R (2004) Different diagnostic techniques for the assessment of cortical bone on osteoporotic animals. Biomed Pharmacother 58:494–499PubMedCrossRef

16.

Verhaeghe J, Thomsen JS, van Bree R, van Herck E, Boullion R, Mosekilde L (2000) Effects of exercise and disuse on bone remodeling, bone mass, and biomechanical competence in spontaneously diabetic female rats. Bone 27:249–256PubMedCrossRef

17.

Ferreti JL, Cointry GR, Capozza RF, Capiglioni R, Chiappe MA (2001) Analysis of biomechanical effects on bone and on the muscle–bone interactions in small animal models. J Musculoskelet Neuronal Interact 1:263–274

18.

Norimatsu H, Mori S, Kawanishi J, Kaji Y, Li J (1997) Immobilization as the pathogenesis of osteoporosis:experimental and clinical studies. Osteoporos Int 7:S57–S62PubMed

19.

Sievanen H, Kannus P, Jarvinen TL (1997) Immobilization distorts allometry of rat femur: implications for disuse osteoporosis. Calcif Tissue Int 60:387–390PubMedCrossRef

20.

Yingling VR, Davies S, Silva MJ (2001) The effects of repetitive physiologic loading on bone turnover and mechanical properties in adult female and male rats. Calcif Tissue Int 68:235–239PubMedCrossRef

Title: Prospective use of dual-energy X-ray absorptiometry in a model of immobilization and exercise in rats: the preliminary results
Authors: Ayce Atalay
Murat Yildirim
Yesim Gokce-Kutsal
Rustu Onur
Macit Arıyurek
Publication date: 01-07-2008
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 9/2008
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-008-0539-2

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 9/2008

Early stage of adjuvant arthritis alters behavioral responses in male but not female rats

Can tumor necrosis factor receptor II gene 676T>G polymorphism predict the response grading to anti-TNFα therapy in rheumatoid arthritis?

Longstanding epileptic encephalopathy and linear localized scleroderma: two distinct pathologic processes in an adolescent

Effectiveness of aquatic therapy in the treatment of fibromyalgia syndrome: a randomized controlled open study

Anaplastic large cell lymphoma presenting with symmetric polyarthritis in pregnancy

Association of TIMP-4 gene polymorphism with the risk of osteoarthritis in the Korean population

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials