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Published in: Osteoporosis International 2/2016

01-02-2016 | Original Article

Prospective study of predictive factors of changes in pain and hip function after hip fracture among the elderly

Authors: M. Orive, A. Anton-Ladislao, S. García-Gutiérrez, C. Las Hayas, N. González, J. Zabala, J. M. Quintana

Published in: Osteoporosis International | Issue 2/2016

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Abstract

Summary

Our study identified pre-fracture variables, such as home status or function, that are directly or indirectly associated with frailty status before fracture. The prevention in the deterioration of those variables would improve the prognosis of those hip fractured, being this an important issue for the societies with increasingly aging population.

Introduction

This study was designed to identify predictors of pain and declines in function among elderly patients following a fall-related hip fracture.

Methods

Patients aged 65 or older with a fall-related hip fracture retrospectively completed pre-fracture status questionnaires (T0; n = 740) and were then prospectively followed for 6 months (T1; n = 546). Of these, 474 were randomly selected to complete an additional 18 months of follow-up (T2; n = 356). Primary outcome measures were changes in the pain and function dimensions of the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire’s short form (WOMAC-SF). Potential predictors included sociodemographic variables, in-hospital and clinical pre- and post-fracture data, and activities of daily living at baseline and follow-up. Multivariate logistic regression was used for analysis.

Results

Predictors of worsening pain at T1 and/or T2 included living in a home care situation or nursing home before the fracture (OR at T1, 1.515; OR at T2, 2.749), and low pre-fracture pain (OR at T1, 1.028; OR at T2, 1.027). Predictors of deterioration in function at T1 and/or T2 included age ≥85 years (OR at T1, 2.714; OR at T2, 4.762), lower income (OR at T1, 1.755), high pre-fracture hip function (OR at T1, 1.029; OR at T2, 1.028), referral to rehabilitation upon discharge (OR at T1, 2.378; OR at T2, 2.881), and longer delay between fall and surgery (OR at T1, 1.133; OR at T2, 1.124).

Conclusions

Frailty before hip fracture is a predictor of greater post-fracture pain and deterioration in function. Given that exercise programs help prevent frailty, promoting exercise in elderly may improve the prognosis of hip fracture.
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Literature
1.
go back to reference Frost SA, Nguyen ND, Black DA, Eisman JA, Nguyen TV (2011) Risk factors for in-hospital post-hip fracture mortality. Bone 49:553–558CrossRefPubMed Frost SA, Nguyen ND, Black DA, Eisman JA, Nguyen TV (2011) Risk factors for in-hospital post-hip fracture mortality. Bone 49:553–558CrossRefPubMed
2.
go back to reference Flikweert ER, Izaks GJ, Reininga IH, Wendt KW, Stevens M (2013) Evaluation of the effect of a comprehensive multidisciplinary care pathway for hip fractures: design of a controlled study. BMC Musculoskelet Disord 14:291PubMedCentralCrossRefPubMed Flikweert ER, Izaks GJ, Reininga IH, Wendt KW, Stevens M (2013) Evaluation of the effect of a comprehensive multidisciplinary care pathway for hip fractures: design of a controlled study. BMC Musculoskelet Disord 14:291PubMedCentralCrossRefPubMed
3.
go back to reference Haentjens P, Magaziner J, Colon-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B, Boonen S (2010) Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med 152:380–390PubMedCentralCrossRefPubMed Haentjens P, Magaziner J, Colon-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B, Boonen S (2010) Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med 152:380–390PubMedCentralCrossRefPubMed
4.
go back to reference Edwards M, Baptiste S, Stratford PW, Law M (2007) Recovery after hip fracture: what can we learn from the Canadian occupational performance measure? Am J Occup Ther 61:335–344CrossRefPubMed Edwards M, Baptiste S, Stratford PW, Law M (2007) Recovery after hip fracture: what can we learn from the Canadian occupational performance measure? Am J Occup Ther 61:335–344CrossRefPubMed
5.
go back to reference Kristensen MT (2011) Factors affecting functional prognosis of patients with hip fracture. Eur J Phys Rehabil Med 47:257–264PubMed Kristensen MT (2011) Factors affecting functional prognosis of patients with hip fracture. Eur J Phys Rehabil Med 47:257–264PubMed
6.
go back to reference Buecking B, Struewer J, Waldermann A, Horstmann K, Schubert N, Balzer-Geldsetzer M, Dodel R, Bohl K, Ruchholtz S, Bliemel C (2014) What determines health-related quality of life in hip fracture patients at the end of acute care?-a prospective observational study. Osteoporos Int 25:475–484CrossRefPubMed Buecking B, Struewer J, Waldermann A, Horstmann K, Schubert N, Balzer-Geldsetzer M, Dodel R, Bohl K, Ruchholtz S, Bliemel C (2014) What determines health-related quality of life in hip fracture patients at the end of acute care?-a prospective observational study. Osteoporos Int 25:475–484CrossRefPubMed
7.
go back to reference Rohde G, Haugeberg G, Mengshoel AM, Moun R, Wahl AK (2008) Is global quality of life reduced before fracture in patients with low-energy wrist or hip fracture? A comparison with matched controls. Health Qual LifeOutcomes 6:90–101CrossRef Rohde G, Haugeberg G, Mengshoel AM, Moun R, Wahl AK (2008) Is global quality of life reduced before fracture in patients with low-energy wrist or hip fracture? A comparison with matched controls. Health Qual LifeOutcomes 6:90–101CrossRef
8.
go back to reference Shyu YI, Chen ML, Chen MC, Wu CC, Su JY (2009) Postoperative pain and its impact on quality of life for hip-fractured older people over 12 months after hospital discharge. J Clin Nurs 18:755–764CrossRefPubMed Shyu YI, Chen ML, Chen MC, Wu CC, Su JY (2009) Postoperative pain and its impact on quality of life for hip-fractured older people over 12 months after hospital discharge. J Clin Nurs 18:755–764CrossRefPubMed
9.
go back to reference Lin WP, Wen CJ, Jiang CC, Hou SM, Chen CY, Lin J (2011) Risk factors for hip fracture sites and mortality in older adults. J Trauma 71:191–197CrossRefPubMed Lin WP, Wen CJ, Jiang CC, Hou SM, Chen CY, Lin J (2011) Risk factors for hip fracture sites and mortality in older adults. J Trauma 71:191–197CrossRefPubMed
10.
go back to reference Leibson CL, Tosteson AN, Gabriel SE, Ransom JE, Melton LJ (2002) Mortality, disability, and nursing home use for persons with and without hip fracture: a population-based study. J Am Geriatr Soc 50:1644–1650CrossRefPubMed Leibson CL, Tosteson AN, Gabriel SE, Ransom JE, Melton LJ (2002) Mortality, disability, and nursing home use for persons with and without hip fracture: a population-based study. J Am Geriatr Soc 50:1644–1650CrossRefPubMed
11.
go back to reference Davis AM, Agnidis Z, Badley E, Kiss A, Waddell JP, Gross AE (2006) Predictors of functional outcome two years following revision hip arthroplasty. J Bone Joint Surg Am 88:685–691CrossRefPubMed Davis AM, Agnidis Z, Badley E, Kiss A, Waddell JP, Gross AE (2006) Predictors of functional outcome two years following revision hip arthroplasty. J Bone Joint Surg Am 88:685–691CrossRefPubMed
12.
go back to reference Soteriades ES, Evans JC, Larson MG, Chen MH, Chen L, Benjamin EJ, Levy D (2002) Incidence and prognosis of syncope. N Engl J Med 347:878–885CrossRefPubMed Soteriades ES, Evans JC, Larson MG, Chen MH, Chen L, Benjamin EJ, Levy D (2002) Incidence and prognosis of syncope. N Engl J Med 347:878–885CrossRefPubMed
13.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383CrossRefPubMed Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383CrossRefPubMed
14.
go back to reference Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15:1833–1840PubMed Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15:1833–1840PubMed
15.
go back to reference Macaulay W, Nellans KW, Garvin KL, Iorio R, Healy WL, Rosenwasser MP (2008) Prospective randomized clinical trial comparing hemiarthroplasty to total hip arthroplasty in the treatment of displaced femoral neck fractures: winner of the Dorr award. J Arthroplasty 23:2–8CrossRefPubMed Macaulay W, Nellans KW, Garvin KL, Iorio R, Healy WL, Rosenwasser MP (2008) Prospective randomized clinical trial comparing hemiarthroplasty to total hip arthroplasty in the treatment of displaced femoral neck fractures: winner of the Dorr award. J Arthroplasty 23:2–8CrossRefPubMed
16.
go back to reference Davis AM, Badley EM, Beaton DE, Kopec J, Wright JG, Young NL, Williams JI (2003) Rasch analysis of the western Ontario McMaster (WOMAC) osteoarthritis index: results from community and arthroplasty samples. J Clin Epidemiol 56:1076–1083CrossRefPubMed Davis AM, Badley EM, Beaton DE, Kopec J, Wright JG, Young NL, Williams JI (2003) Rasch analysis of the western Ontario McMaster (WOMAC) osteoarthritis index: results from community and arthroplasty samples. J Clin Epidemiol 56:1076–1083CrossRefPubMed
17.
go back to reference Bilbao A, Quintana JM, Escobar A, Las Hayas C, Orive M (2011) Validation of a proposed WOMAC short form for patients with hip osteoarthritis. Health Qual Life Outcomes 9:75–85PubMedCentralCrossRefPubMed Bilbao A, Quintana JM, Escobar A, Las Hayas C, Orive M (2011) Validation of a proposed WOMAC short form for patients with hip osteoarthritis. Health Qual Life Outcomes 9:75–85PubMedCentralCrossRefPubMed
18.
go back to reference Mahoney FI, Barthel DW (1965) Functional evaluation: the Barthel index. Md State Med J 14:61–65PubMed Mahoney FI, Barthel DW (1965) Functional evaluation: the Barthel index. Md State Med J 14:61–65PubMed
19.
go back to reference Baztán JJ, Pérez J, Alarcón SC, Izquierdo E, Manzarbeitia J (1993) Indice de Barthel: instrumento válido para la valoración funcional de pacientes con enfermedad cerebrovascular. Rev Esp Geriatr Gerontol 28:32–40 Baztán JJ, Pérez J, Alarcón SC, Izquierdo E, Manzarbeitia J (1993) Indice de Barthel: instrumento válido para la valoración funcional de pacientes con enfermedad cerebrovascular. Rev Esp Geriatr Gerontol 28:32–40
20.
go back to reference Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. The Gerontologist 9:179–186CrossRefPubMed Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. The Gerontologist 9:179–186CrossRefPubMed
21.
go back to reference Vergara I, Bilbao A, Orive M, Garcia-Gutierrez S, Navarro G, Quintana JM (2012) Validation of the Spanish version of the Lawton IADL scale for its application in elderly people. Health Qual Life Outcomes 10:130PubMedCentralCrossRefPubMed Vergara I, Bilbao A, Orive M, Garcia-Gutierrez S, Navarro G, Quintana JM (2012) Validation of the Spanish version of the Lawton IADL scale for its application in elderly people. Health Qual Life Outcomes 10:130PubMedCentralCrossRefPubMed
22.
go back to reference Revicki D, Hays RD, Cella D, Sloan J (2008) Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes. J Clin Epidemiol 61:102–109CrossRefPubMed Revicki D, Hays RD, Cella D, Sloan J (2008) Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes. J Clin Epidemiol 61:102–109CrossRefPubMed
23.
go back to reference Morrison RS, Magaziner J, McLaughlin MA, Orosz G, Silberzweig SB, Koval KJ, Siu AL (2003) The impact of post-operative pain on outcomes following hip fracture. Pain 103:303–311CrossRefPubMed Morrison RS, Magaziner J, McLaughlin MA, Orosz G, Silberzweig SB, Koval KJ, Siu AL (2003) The impact of post-operative pain on outcomes following hip fracture. Pain 103:303–311CrossRefPubMed
24.
go back to reference Strike SA, Sieber FE, Gottschalk A, Mears SC (2013) Role of fracture and repair type on pain and opioid use after hip fracture in the elderly. Geriatr Orthop Surg Rehabil 4:103–108PubMedCentralCrossRefPubMed Strike SA, Sieber FE, Gottschalk A, Mears SC (2013) Role of fracture and repair type on pain and opioid use after hip fracture in the elderly. Geriatr Orthop Surg Rehabil 4:103–108PubMedCentralCrossRefPubMed
25.
go back to reference Cobo CM (2014) The influence of institutionalization on the perception of autonomy and quality of life in old people. Rev Esc Enferm U S P 48:1013–1019CrossRef Cobo CM (2014) The influence of institutionalization on the perception of autonomy and quality of life in old people. Rev Esc Enferm U S P 48:1013–1019CrossRef
26.
go back to reference Yumin ET, Simsek TT, Sertel M, Ozturk A, Yumin M (2011) The effect of functional mobility and balance on health-related quality of life (HRQoL) among elderly people living at home and those living in nursing home. Arch Gerontol Geriatr 52:e180–e184CrossRefPubMed Yumin ET, Simsek TT, Sertel M, Ozturk A, Yumin M (2011) The effect of functional mobility and balance on health-related quality of life (HRQoL) among elderly people living at home and those living in nursing home. Arch Gerontol Geriatr 52:e180–e184CrossRefPubMed
27.
go back to reference Borgstrom F, Lekander I, Ivergard M, Strom O, Svedbom A, Alekna V, Bianchi ML, Clark P, Curiel MD, Dimai HP, Jurisson M, Kallikorm R, Lesnyak O, McCloskey E, Nassonov E, Sanders KM, Silverman S, Tamulaitiene M, Thomas T, Tosteson AN, Jonsson B, Kanis JA (2013) The international costs and utilities related to osteoporotic fractures study (ICUROS)—quality of life during the first 4 months after fracture. Osteoporos Int 24:811–823CrossRefPubMed Borgstrom F, Lekander I, Ivergard M, Strom O, Svedbom A, Alekna V, Bianchi ML, Clark P, Curiel MD, Dimai HP, Jurisson M, Kallikorm R, Lesnyak O, McCloskey E, Nassonov E, Sanders KM, Silverman S, Tamulaitiene M, Thomas T, Tosteson AN, Jonsson B, Kanis JA (2013) The international costs and utilities related to osteoporotic fractures study (ICUROS)—quality of life during the first 4 months after fracture. Osteoporos Int 24:811–823CrossRefPubMed
28.
go back to reference Fortin PR, Clarke AE, Joseph L, Liang MH, Tanzer M, Ferland D, Phillips C, Partridge AJ, Belisle P, Fossel AH, Mahomed N, Sledge CB, Katz JN (1999) Outcomes of total hip and knee replacement: preoperative functional status predicts outcomes at six months after surgery. Arthritis Rheum 42:1722–1728CrossRefPubMed Fortin PR, Clarke AE, Joseph L, Liang MH, Tanzer M, Ferland D, Phillips C, Partridge AJ, Belisle P, Fossel AH, Mahomed N, Sledge CB, Katz JN (1999) Outcomes of total hip and knee replacement: preoperative functional status predicts outcomes at six months after surgery. Arthritis Rheum 42:1722–1728CrossRefPubMed
29.
go back to reference Salpakoski A, Tormakangas T, Edgren J, Sihvonen S, Pekkonen M, Heinonen A, Pesola M, Kallinen M, Rantanen T, Sipila S (2014) Walking recovery after a hip fracture: a prospective follow-up study among community-dwelling over 60-year old men and women. Biomed Res Int 2014:289549PubMedCentralCrossRefPubMed Salpakoski A, Tormakangas T, Edgren J, Sihvonen S, Pekkonen M, Heinonen A, Pesola M, Kallinen M, Rantanen T, Sipila S (2014) Walking recovery after a hip fracture: a prospective follow-up study among community-dwelling over 60-year old men and women. Biomed Res Int 2014:289549PubMedCentralCrossRefPubMed
30.
go back to reference National Institute for Health Excellence Care (2011) The management of hip fracture in adults. Royal College of Physicians, UK National Institute for Health Excellence Care (2011) The management of hip fracture in adults. Royal College of Physicians, UK
31.
go back to reference Scotish Intercollegiate Guideline Network (SIGN) (2011) Management of hip fracture in older people. Scotish Intercollegiate Guideline Network (SIGN), Edinburgh Scotish Intercollegiate Guideline Network (SIGN) (2011) Management of hip fracture in older people. Scotish Intercollegiate Guideline Network (SIGN), Edinburgh
32.
go back to reference Nascimento CM, Ribeiro AQ, Cotta RM, Acurcio FA, Peixoto SV, Priore SE, Franceschini SC (2012) Factors associated with functional ability in Brazilian elderly. Arch Gerontol Geriatr 54:e89–e94CrossRef Nascimento CM, Ribeiro AQ, Cotta RM, Acurcio FA, Peixoto SV, Priore SE, Franceschini SC (2012) Factors associated with functional ability in Brazilian elderly. Arch Gerontol Geriatr 54:e89–e94CrossRef
33.
go back to reference Wylde V, Dieppe P, Hewlett S, Learmonth ID (2007) Total knee replacement: is it really an effective procedure for all? Knee 14:417–423CrossRefPubMed Wylde V, Dieppe P, Hewlett S, Learmonth ID (2007) Total knee replacement: is it really an effective procedure for all? Knee 14:417–423CrossRefPubMed
34.
go back to reference Lantz PM, House JS, Lepkowski JM, Williams DR, Mero RP, Chen J (1998) Socioeconomic factors, health behaviors, and mortality: results from a nationally representative prospective study of US adults. JAMA 279:1703–1708CrossRefPubMed Lantz PM, House JS, Lepkowski JM, Williams DR, Mero RP, Chen J (1998) Socioeconomic factors, health behaviors, and mortality: results from a nationally representative prospective study of US adults. JAMA 279:1703–1708CrossRefPubMed
Metadata
Title
Prospective study of predictive factors of changes in pain and hip function after hip fracture among the elderly
Authors
M. Orive
A. Anton-Ladislao
S. García-Gutiérrez
C. Las Hayas
N. González
J. Zabala
J. M. Quintana
Publication date
01-02-2016
Publisher
Springer London
Published in
Osteoporosis International / Issue 2/2016
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-015-3267-y

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