Top

Japanese Journal of Ophthalmology

Published in:

01-05-2012 | Clinical Investigation

Prospective multicenter study of visual outcomes following three different treatments for macular edema associated with branch retinal vein occlusion: a study by the Japanese BRVO study group

Authors: Seiyo Harino, Kenichiro Bessho, Teruyo Kida

Published in: Japanese Journal of Ophthalmology | Issue 3/2012

Abstract

Purpose

To evaluate the visual outcomes of three different treatments for macular edema associated with a branch retinal vein occlusion.

Methods

A 1-year, non-randomized study was conducted at 21 ophthalmological institutes in Japan. All of the patients received one of three treatments: medication per-oral (PO), photocoagulation (PC) or pars plana vitrectomy (PPV). Retinal hemorrhage that was lower than that shown in reference photographs was considered an inclusion criteria.

Results

Ninety-eight patients were studied. Twenty-six (26.5%) patients were in the PO, 37 (37.8%) in the PC and 35 (35.7%) in the PPV group. The mean best-corrected visual acuity (BCVA) improved significantly after 1 year in all groups (P < 0.001). There was no significant difference among those groups in the degree of the BCVA improvement. However, the BCVA in the PPV group improved significantly at 6 months, significantly earlier than in the other two groups. The BCVA at entry in the PPV group was significantly worst among patients whose eyes had a BCVA of ≥0.7 at 1 year (P < 0.05).

Conclusions

PPV had a slight advantage over PC and PO, although the improvement to the BCVA did not differ significantly following any of the three treatments.

Mitchell P, Smith W, Chang A. Prevalence and associations of retinal vein occlusion in Australia. The Blue Mountains Eye Study. Arch Ophthalmol. 1996;114:1243–7.PubMedCrossRef

Klein R, Klein BE, Moss SE, Meuer SM. The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study. Trans Am Ophthalmol Soc. 2000;98:133–41.PubMed

Michels RG, Gass JD. The natural course of retinal branch vein obstruction. Trans Am Acad Ophthalmol Otolaryngol. 1974;78:166–77.

Gutman FA. Macular edema in branch retinal vein occlusion: prognosis and management. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1977;83:488–95.PubMed

Gutman FA, Zegarra H. The natural course of temporal retinal branch vein occlusion. Trans Am Acad Ophthalmol Otolaryngol. 1974;78:178–92.

Magargal LE, Kimmel AS, Sanborn GE, Annesley WH Jr. Temporal branch retinal vein obstruction: a review. Ophthalmic Surg. 1986;17:240–6.PubMed

Finkelstein D. Ischemic macular edema. Recognition and favorable natural history in branch vein occlusion. Arch Ophthalmol. 1992;110:1427–34.PubMedCrossRef

The Branch Vein Occlusion Study Group. Argon laser photocoagulation for macular edema in branch vein occlusion. Am J Ophthalmol. 1984;98:271–82.

McIntosh RL, Mohamed Q, Saw SM, Wong TY. Interventions for branch retinal vein occlusion: an evidence-based systematic review. Ophthalmology. 2007;114:835–54.PubMedCrossRef

10.

Scott IU, Ip MS, VanVeldhuisen PC, Oden NL, Blodi BA, Fisher M, et al. A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular Edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 6. Arch Ophthalmol. 2009;127:1115–28.PubMedCrossRef

11.

Tachi N, Hashimoto Y, Ogino N. Vitrectomy for macular edema combined with retinal vein occlusion. Doc Ophthalmol. 1999;97:465–9.PubMedCrossRef

12.

Saika S, Tanaka T, Miyamoto T, Ohnishi Y. Surgical posterior vitreous detachment combined with gas/air tamponade for treating macular edema associated with branch retinal vein occlusion: retinal tomography and visual outcome. Graefes Arch Clin Exp Ophthalmol. 2001;239:729–32.PubMedCrossRef

13.

Kumagai K, Furukawa M, Ogino N, Uemura A, Larson E. Long-term outcomes of vitrectomy with or without arteriovenous sheathotomy in branch retinal vein occlusion. Retina. 2007;27:49–54.PubMedCrossRef

14.

Osterloh MD, Charles S. Surgical decompression of branch retinal vein occlusions. Arch Ophthalmol. 1988;106:1469–71.PubMedCrossRef

15.

Opremcak EM, Bruce RA. Surgical decompression of branch retinal vein occlusion via arteriovenous crossing sheathotomy: a prospective review of 15 cases. Retina. 1999;19:1–5.PubMedCrossRef

16.

Figueroa MS, Torres R, Alvarez MT. Comparative study of vitrectomy with and without vein decompression for branch retinal vein occlusion: a pilot study. Eur J Ophthalmol. 2004;14:40–7.PubMed

17.

Charbonnel J, Glacet-Bernard A, Korobelnik JF, Nyouma-Moune E, Pournaras CJ, Colin J, et al. Management of branch retinal vein occlusion with vitrectomy and arteriovenous adventitial sheathotomy, the possible role of surgical posterior vitreous detachment. Graefes Arch Clin Exp Ophthalmol. 2004;242:223–8.PubMedCrossRef

18.

Arai M, Yamamoto S, Mitamura Y, Sato E, Sugawara T, Mizunoya S. Efficacy of vitrectomy and internal limiting membrane removal for macular edema associated with branch retinal vein occlusion. Ophthalmologica. 2009;223:172–6.PubMedCrossRef

19.

Raszewska-Steglinska M, Gozdek P, Cisiecki S, Michalewska Z, Michalewski J, Nawrocki J. Pars plana vitrectomy with ILM peeling for macular edema secondary to retinal vein occlusion. Eur J Ophthalmol. 2009;19:1055–62.PubMed

20.

Hayreh SS, Zimmerman MB, Podhajsky P. Incidence of various types of retinal vein occlusion and their recurrence and demographic characteristics. Am J Ophthalmol. 1994;117:429–41.PubMed

21.

Yamaguchi Y, Otani T, Kishi S. Serous macular detachment in branch retinal vein occlusion. Retina. 2006;26:1029–33.PubMedCrossRef

22.

Parodi MB, Bandello F. Branch retinal vein occlusion: classification and treatment. Ophthalmologica. 2009;223:298–305.PubMedCrossRef

23.

Sendo T, Itoh Y, Aki K, Oka M, Oishi R. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2003;368:175–80.PubMedCrossRef

24.

Yamaguchi T, Nagano H, Yamaguchi M, Suzuki T, Saito Y, Tano Y. The effects of kallidinogenase on choroidal blood flow in a hypertensive rabbit model. Curr Eye Res. 1999;18:417–22.PubMedCrossRef

25.

Fukaya Y, Tamaki Y, Tomidokoro A, Araie M. Effects of kallidinogenase on ocular tissue circulation in rabbits. J Ocul Pharmacol Ther. 2002;18:515–24.PubMedCrossRef

26.

Ogura Y, Takanashi T, Ishigooka H, Ogino N. Quantitative analysis of lens changes after vitrectomy by fluorophotometry. Am J Ophthalmol. 1991;111:179–83.PubMed

27.

Christoffersen NL, Larsen M. Pathophysiology and hemodynamics of branch retinal vein occlusion. Ophthalmology. 1999;106:2054–62.PubMedCrossRef

28.

Glacet-Bernard A, Coscas G, Chabanel A, Zourdani A, Lelong F, Samama MM. A randomized, double-masked study on the treatment of retinal vein occlusion with troxerutin. Am J Ophthalmol. 1994;118:421–9.PubMed

29.

Hattenbach LO, Friedrich Arndt C, Lerche R, Scharrer I, Baatz H, Margaron F, et al. Retinal vein occlusion and low-dose fibrinolytic therapy (R.O.L.F.): a prospective, randomized, controlled multicenter study of low-dose recombinant tissue plasminogen activator versus hemodilution in retinal vein occlusion. Retina. 2009;29:932–40.

30.

David R, Zangwill L, Badarna M, Yassur Y. Epidemiology of retinal vein occlusion and its association with glaucoma and increased intraocular pressure. Ophthalmologica. 1988;197:69–74.PubMedCrossRef

31.

Sperduto RD, Hiller R, Chew E, Seigel D, Blair N, Burton TC, et al. Risk factors for hemiretinal vein occlusion: comparison with risk factors for central and branch retinal vein occlusion: the eye disease case-control study. Ophthalmology. 1998;105:765–71.PubMedCrossRef

32.

Basile M, Gidaro S, Pacella M, Biffignandi PM, Gidaro GS. Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study. Curr Med Res Opin. 2001;17:256–61.PubMed

33.

Kato N, Hou Y, Lu Z, Lu C, Nagano H, Suzuma K, Takagi H, et al. Kallidinogenase normalizes retinal vasopermeability in streptozotocin-induced diabetic rats: potential roles of vascular endothelial growth factor and nitric oxide. Eur J Pharmacol. 2009;606:187–90.PubMedCrossRef

34.

Yamamoto S, Saito W, Yagi F, Takeuchi S, Sato E, Mizunoya S. Vitrectomy with or without arteriovenous adventitial sheathotomy for macular edema associated with branch retinal vein occlusion. Am J Ophthalmol. 2004;138:907–14.PubMedCrossRef

35.

Kumagai K, Furukawa M, Ogino N, Larson E, Uemura A. Long-term visual outcomes after vitrectomy for macular edema with foveal hemorrhage in branch retinal vein occlusion. Retina. 2007;27:584–8.PubMedCrossRef

36.

Lang GE, Freissler K. Clinical and fluorescein angiography findings in patients with retinal vein occlusion. A unicenter study of 211 patients. Klin Monbl Augenheilkd. 1992;201:234–9.

37.

Mason J 3rd, Feist R, White M Jr, Swanner J, McGwin G Jr, Emond T. Sheathotomy to decompress branch retinal vein occlusion: a matched control study. Ophthalmology. 2004;111:540–5.PubMedCrossRef

38.

Joffe L, Goldberg RE, Magargal LE, Annesley WH. Macular branch vein occlusion. Ophthalmology. 1980;87:91–8.PubMed

39.

Battaglia Parodi M, Saviano S, Ravalico G. Grid laser treatment in macular branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 1999;237:1024–7.

40.

Parodi MB, Visintin F, Della Rupe P, Ravalico G. Foveal avascular zone in macular branch retinal vein occlusion. Int Ophthalmol. 1995;19:25–8.PubMedCrossRef

Title: Prospective multicenter study of visual outcomes following three different treatments for macular edema associated with branch retinal vein occlusion: a study by the Japanese BRVO study group
Authors: Seiyo Harino
Kenichiro Bessho
Teruyo Kida
Publication date: 01-05-2012
Publisher: Springer Japan
Published in: Japanese Journal of Ophthalmology / Issue 3/2012
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI: https://doi.org/10.1007/s10384-012-0121-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prospective multicenter study of visual outcomes following three different treatments for macular edema associated with branch retinal vein occlusion: a study by the Japanese BRVO study group

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 3/2012

Evaluation of iron, zinc, and copper levels in pterygium tissue

Clinical evaluation of non-Descemet stripping automated endothelial keratoplasty (nDSAEK)

Enhanced depth imaging spectral-domain optical coherence tomography of subfoveal choroidal thickness in normal Japanese eyes

Sweet's syndrome with panuveitis resembling Behçet's disease

Factors affecting imaging of spectral-domain optical coherence tomography in gas-filled eyes after macular-hole surgery

Punctal plugs for treatment of post-LASIK dry eye