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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 10/2017

01-10-2017 | Original Article

Prospective Evaluation of Associations between Cancer-Related Pain and Perineural Invasion in Patients with Resectable Pancreatic Adenocarcinoma

Authors: Rosalie A. Carr, Alexandra M. Roch, Xin Zhong, Eugene P. Ceppa, Nicholas J. Zyromski, Attila Nakeeb, C. Max Schmidt, Michael G. House

Published in: Journal of Gastrointestinal Surgery | Issue 10/2017

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Abstract

Introduction

Perineural invasion is a unique characteristic of pancreatic adenocarcinoma biology and is present in the majority of resected pathologic specimens. The purpose of this study was to understand the relationships between preoperative pain and perineural invasion in patients with pancreatic adenocarcinoma.

Methods

Fifty-two chemotherapy naive patients undergoing resection for pancreatic adenocarcinoma from 2012 to 2014 completed a previously validated Brief Pain Inventory survey for preoperative clinical pain scoring. Preoperative pain was correlated with multiple clinicopathologic features.

Results

Preoperative pain was not associated with pathologic cancer stage, lymph node status, lymph node positivity ratio, resection margin status, or tumor location within the pancreas. In the subgroup of pancreatic head cancers, pain interference with affect was associated with the absence of perineural invasion (p = 0.02). Patients with stage I cancer had higher pain interference scores than those with stage II cancer (p = 0.02).

Conclusions

Preoperative pain does not predict the presence of perineural invasion or other pathologic prognostic factors in patients with resectable pancreatic adenocarcinoma. Higher pain scores in pancreatic head cancers correlated with absence of perineural invasion and early cancer stage. The effects of preoperative pain on quality and interference of daily life deserve further investigation in larger prospective studies involving patients with pancreatic cancer.
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Metadata
Title
Prospective Evaluation of Associations between Cancer-Related Pain and Perineural Invasion in Patients with Resectable Pancreatic Adenocarcinoma
Authors
Rosalie A. Carr
Alexandra M. Roch
Xin Zhong
Eugene P. Ceppa
Nicholas J. Zyromski
Attila Nakeeb
C. Max Schmidt
Michael G. House
Publication date
01-10-2017
Publisher
Springer US
Published in
Journal of Gastrointestinal Surgery / Issue 10/2017
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-017-3513-z

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