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memo - Magazine of European Medical Oncology

09-02-2024 | Propranolol | original report

β-adrenergic modulation of IL-6/gp130 and SOCS-1 in multiple myeloma: therapeutic strategy for stress induced-inflammatory response

Authors: Raika Naiebi, Saeid Abroun, Ph. D., Amir Atashi, Leila Shafiee, Mohammadarian Akbari, Mohammad Hasan Maleki, Morvarid Siri, M. Sc.

Published in: memo - Magazine of European Medical Oncology

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Summary

Purpose

Multiple Myeloma (MM) is considered an incurable, biologically heterogeneous disease of the plasma cells. The clinical data on the association between stress and the molecular mechanism of stress hormone receptor expression and its relationship with IL‑6 signaling pathway have not yet proposed a clear answer in MM. This study aims to explore the effect of isoproterenol and propranolol, which are beta-adrenergic agonists and antagonists, respectively on suppressor of cytokine signaling (SOCS) and IL-6/gp130 signaling in MM cell lines.

Material and methods

Four different MM cell lines (KMM‑1, RPMI 8226, LP‑1, and L363) were treated with isoproterenol and propranolol. Optimal dosages of isoproterenol and propranolol were determined, and the mRNA expression levels of IL‑6, gp130, and SOCS‑1 were examined using qRT-PCR.

Results

The analysis of our results indicated that propranolol, as a β-adrenoreceptor antagonist, could increase MM cell death and ameliorate IL‑6 and its receptor gp130 in addition to up-regulate SOCS‑1 gene expression. On the other hand, isoproterenol, as a β-adrenoreceptor agonist, could provoke MM cell viability and IL‑6 expression.

Conclusions

β‑adrenergic signaling seems to affect cell viability through targeting IL-6/gp130 and SOCS‑1 signaling in MM, underscoring the importance of further studies on stress hormones and IL‑6 suppressors as potent candidates for MM therapy.
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Metadata
Title
β-adrenergic modulation of IL-6/gp130 and SOCS-1 in multiple myeloma: therapeutic strategy for stress induced-inflammatory response
Authors
Raika Naiebi
Saeid Abroun, Ph. D.
Amir Atashi
Leila Shafiee
Mohammadarian Akbari
Mohammad Hasan Maleki
Morvarid Siri, M. Sc.
Publication date
09-02-2024
Publisher
Springer Vienna
Published in
memo - Magazine of European Medical Oncology
Print ISSN: 1865-5041
Electronic ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-024-00962-0
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