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Published in: Child's Nervous System 10/2018

01-10-2018 | Special Annual Issue

Prophylactic antibiotics in pediatric neurological surgery

Authors: Friederike Knerlich-Lukoschus, Martina Messing-Jünger

Published in: Child's Nervous System | Issue 10/2018

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Abstract

Purpose

Surgical antibiotic prophylaxis (SAP) in pediatric neurosurgery has poorly been characterized until now. This review gives an overview on the current literature extracting recommendations and guidelines.

Methods

The current literature on SAP with special forcus on pediatric neurosurgerical procedures was reviewed. Further, available recommendations in online databases were checked. Clean neurosurgical, shunt, and implant surgeries are considered separately.

Results

To date, evidence-based data on SAP in pediatric neurosurgery remain sparse and there are no standardized approaches to an adequate use of antimicrobial agents for SSI prevention for this age group.

Conclusion

Due to statistical needs, multi-center surveillance studies are needed for implementing SAP recommendations in pediatric neurosurgery.
Literature
1.
go back to reference Perencevich EN, Sands KE, Cosgrove SE, Guadagnoli E, Meara E, Platt R (2003) Health and economic impact of surgical site infections diagnosed after hospital discharge. Emerg Infect Dis 9:196–203CrossRefPubMedPubMedCentral Perencevich EN, Sands KE, Cosgrove SE, Guadagnoli E, Meara E, Platt R (2003) Health and economic impact of surgical site infections diagnosed after hospital discharge. Emerg Infect Dis 9:196–203CrossRefPubMedPubMedCentral
2.
3.
go back to reference Woodgate RL, Tailor K, Yanofsky R, Vanan MI (2016) Childhood brain cancer and its psychosocial impact on survivors and their parents: a qualitative thematic synthesis. Eur J Oncol Nurs 20:140–149CrossRefPubMed Woodgate RL, Tailor K, Yanofsky R, Vanan MI (2016) Childhood brain cancer and its psychosocial impact on survivors and their parents: a qualitative thematic synthesis. Eur J Oncol Nurs 20:140–149CrossRefPubMed
4.
go back to reference Davies BM, Jones A, Patel HC (2016) Surgical-site infection surveillance in cranial neurosurgery. Br J Neurosurg 30:35–37CrossRefPubMed Davies BM, Jones A, Patel HC (2016) Surgical-site infection surveillance in cranial neurosurgery. Br J Neurosurg 30:35–37CrossRefPubMed
6.
go back to reference Karhade AV, Cote DJ, Larsen AM, Smith TR (2017) Neurosurgical infection rates and risk factors: a National Surgical Quality Improvement Program Analysis of 132,000 patients, 2006–2014. World Neurosurg 97:205–212CrossRefPubMed Karhade AV, Cote DJ, Larsen AM, Smith TR (2017) Neurosurgical infection rates and risk factors: a National Surgical Quality Improvement Program Analysis of 132,000 patients, 2006–2014. World Neurosurg 97:205–212CrossRefPubMed
7.
go back to reference Malis LI (1979) Prevention of neurosurgical infection by intraoperative antibiotics. Neurosurgery 5:339–343PubMed Malis LI (1979) Prevention of neurosurgical infection by intraoperative antibiotics. Neurosurgery 5:339–343PubMed
8.
go back to reference Cruse PJ, Foord R (1980) The epidemiology of wound infection. A 10-year prospective study of 62,939 wounds. Surg Clin North Am 60:27–40CrossRefPubMed Cruse PJ, Foord R (1980) The epidemiology of wound infection. A 10-year prospective study of 62,939 wounds. Surg Clin North Am 60:27–40CrossRefPubMed
9.
go back to reference Barker FG 2nd (1994) Efficacy of prophylactic antibiotics for craniotomy: a meta-analysis. Neurosurgery 35:484–490 discussion 491–482CrossRefPubMed Barker FG 2nd (1994) Efficacy of prophylactic antibiotics for craniotomy: a meta-analysis. Neurosurgery 35:484–490 discussion 491–482CrossRefPubMed
10.
go back to reference Blomstedt GC, Kytta J (1988) Results of a randomized trial of vancomycin prophylaxis in craniotomy. J Neurosurg 69:216–220CrossRefPubMed Blomstedt GC, Kytta J (1988) Results of a randomized trial of vancomycin prophylaxis in craniotomy. J Neurosurg 69:216–220CrossRefPubMed
11.
go back to reference Bullock R, van Dellen JR, Ketelbey W, Reinach SG (1988) A double-blind placebo-controlled trial of perioperative prophylactic antibiotics for elective neurosurgery. J Neurosurg 69:687–691CrossRefPubMed Bullock R, van Dellen JR, Ketelbey W, Reinach SG (1988) A double-blind placebo-controlled trial of perioperative prophylactic antibiotics for elective neurosurgery. J Neurosurg 69:687–691CrossRefPubMed
12.
go back to reference Gaillard T, Gilsbach JM (1991) Intra-operative antibiotic prophylaxis in neurosurgery. A prospective, randomized, controlled study on cefotiam. Acta Neurochir 113:103–109CrossRefPubMed Gaillard T, Gilsbach JM (1991) Intra-operative antibiotic prophylaxis in neurosurgery. A prospective, randomized, controlled study on cefotiam. Acta Neurochir 113:103–109CrossRefPubMed
13.
go back to reference Geraghty J, Feely M (1984) Antibiotic prophylaxis in neurosurgery. A randomized controlled trial. J Neurosurg 60:724–726CrossRefPubMed Geraghty J, Feely M (1984) Antibiotic prophylaxis in neurosurgery. A randomized controlled trial. J Neurosurg 60:724–726CrossRefPubMed
14.
go back to reference van Ek B, Dijkmans BA, van Dulken H, van Furth R (1988) Antibiotic prophylaxis in craniotomy: a prospective double-blind placebo-controlled study. Scand J Infect Dis 20:633–639CrossRefPubMed van Ek B, Dijkmans BA, van Dulken H, van Furth R (1988) Antibiotic prophylaxis in craniotomy: a prospective double-blind placebo-controlled study. Scand J Infect Dis 20:633–639CrossRefPubMed
15.
go back to reference Young RF, Lawner PM (1987) Perioperative antibiotic prophylaxis for prevention of postoperative neurosurgical infections. A randomized clinical trial. J Neurosurg 66:701–705CrossRefPubMed Young RF, Lawner PM (1987) Perioperative antibiotic prophylaxis for prevention of postoperative neurosurgical infections. A randomized clinical trial. J Neurosurg 66:701–705CrossRefPubMed
16.
go back to reference Korinek AM, Golmard JL, Elcheick A, Bismuth R, van Effenterre R, Coriat P, Puybasset L (2005) Risk factors for neurosurgical site infections after craniotomy: a critical reappraisal of antibiotic prophylaxis on 4,578 patients. Br J Neurosurg 19:155–162CrossRefPubMed Korinek AM, Golmard JL, Elcheick A, Bismuth R, van Effenterre R, Coriat P, Puybasset L (2005) Risk factors for neurosurgical site infections after craniotomy: a critical reappraisal of antibiotic prophylaxis on 4,578 patients. Br J Neurosurg 19:155–162CrossRefPubMed
17.
go back to reference Korinek AM, Baugnon T, Golmard JL, van Effenterre R, Coriat P, Puybasset L (2006) Risk factors for adult nosocomial meningitis after craniotomy: role of antibiotic prophylaxis. Neurosurgery 59:126–133 discussion 126-133CrossRefPubMed Korinek AM, Baugnon T, Golmard JL, van Effenterre R, Coriat P, Puybasset L (2006) Risk factors for adult nosocomial meningitis after craniotomy: role of antibiotic prophylaxis. Neurosurgery 59:126–133 discussion 126-133CrossRefPubMed
18.
go back to reference Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, Fish DN, Napolitano LM, Sawyer RG, Slain D, Steinberg JP, Weinstein RA (2013) Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm 70:195–283CrossRefPubMed Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, Fish DN, Napolitano LM, Sawyer RG, Slain D, Steinberg JP, Weinstein RA (2013) Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm 70:195–283CrossRefPubMed
19.
go back to reference Haley RW, Culver DH, Morgan WM, White JW, Emori TG, Hooton TM (1985) Identifying patients at high risk of surgical wound infection. A simple multivariate index of patient susceptibility and wound contamination. Am J Epidemiol 121:206–215CrossRefPubMed Haley RW, Culver DH, Morgan WM, White JW, Emori TG, Hooton TM (1985) Identifying patients at high risk of surgical wound infection. A simple multivariate index of patient susceptibility and wound contamination. Am J Epidemiol 121:206–215CrossRefPubMed
20.
go back to reference Kourbeti IS, Jacobs AV, Koslow M, Karabetsos D, Holzman RS (2007) Risk factors associated with postcraniotomy meningitis. Neurosurgery 60:317–325 discussion 325-316CrossRefPubMed Kourbeti IS, Jacobs AV, Koslow M, Karabetsos D, Holzman RS (2007) Risk factors associated with postcraniotomy meningitis. Neurosurgery 60:317–325 discussion 325-316CrossRefPubMed
21.
go back to reference Narotam PK, van Dellen JR, du Trevou MD, Gouws E (1994) Operative sepsis in neurosurgery: a method of classifying surgical cases. Neurosurgery 34:409–415 discussion 415–406CrossRefPubMed Narotam PK, van Dellen JR, du Trevou MD, Gouws E (1994) Operative sepsis in neurosurgery: a method of classifying surgical cases. Neurosurgery 34:409–415 discussion 415–406CrossRefPubMed
22.
go back to reference Spader HS, Hertzler DA, Kestle JR, Riva-Cambrin J (2015) Risk factors for infection and the effect of an institutional shunt protocol on the incidence of ventricular access device infections in preterm infants. J Neurosurg Pediatr 15:156–160CrossRefPubMed Spader HS, Hertzler DA, Kestle JR, Riva-Cambrin J (2015) Risk factors for infection and the effect of an institutional shunt protocol on the incidence of ventricular access device infections in preterm infants. J Neurosurg Pediatr 15:156–160CrossRefPubMed
23.
go back to reference Lee JK, Seok JY, Lee JH, Choi EH, Phi JH, Kim SK, Wang KC, Lee HJ (2012) Incidence and risk factors of ventriculoperitoneal shunt infections in children: a study of 333 consecutive shunts in 6 years. J Korean Med Sci 27:1563–1568CrossRefPubMedPubMedCentral Lee JK, Seok JY, Lee JH, Choi EH, Phi JH, Kim SK, Wang KC, Lee HJ (2012) Incidence and risk factors of ventriculoperitoneal shunt infections in children: a study of 333 consecutive shunts in 6 years. J Korean Med Sci 27:1563–1568CrossRefPubMedPubMedCentral
24.
go back to reference Liu J, Li N, Hao J, Li Y, Liu A, Wu Y, Cai M (2018) Impact of the antibiotic stewardship program on prevention and control of surgical site infection during peri-operative clean surgery. Surg Infect 19:326–333CrossRef Liu J, Li N, Hao J, Li Y, Liu A, Wu Y, Cai M (2018) Impact of the antibiotic stewardship program on prevention and control of surgical site infection during peri-operative clean surgery. Surg Infect 19:326–333CrossRef
25.
go back to reference Classen DC, Evans RS, Pestotnik SL, Horn SD, Menlove RL, Burke JP (1992) The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med 326:281–286CrossRefPubMed Classen DC, Evans RS, Pestotnik SL, Horn SD, Menlove RL, Burke JP (1992) The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med 326:281–286CrossRefPubMed
26.
go back to reference van Ek B, Dijkmans BA, van Dulken H, Mouton RP, Hermans J, van Furth R (1990) Effect of cloxacillin prophylaxis on the bacterial flora of craniotomy wounds. Scand J Infect Dis 22:345–352CrossRefPubMed van Ek B, Dijkmans BA, van Dulken H, Mouton RP, Hermans J, van Furth R (1990) Effect of cloxacillin prophylaxis on the bacterial flora of craniotomy wounds. Scand J Infect Dis 22:345–352CrossRefPubMed
27.
go back to reference Steinberg JP, Braun BI, Hellinger WC, Kusek L, Bozikis MR, Bush AJ, Dellinger EP, Burke JP, Simmons B, Kritchevsky SB, Trial to Reduce Antimicrobial Prophylaxis Errors Study G (2009) Timing of antimicrobial prophylaxis and the risk of surgical site infections: results from the trial to reduce antimicrobial prophylaxis errors. Ann Surg 250:10–16CrossRefPubMed Steinberg JP, Braun BI, Hellinger WC, Kusek L, Bozikis MR, Bush AJ, Dellinger EP, Burke JP, Simmons B, Kritchevsky SB, Trial to Reduce Antimicrobial Prophylaxis Errors Study G (2009) Timing of antimicrobial prophylaxis and the risk of surgical site infections: results from the trial to reduce antimicrobial prophylaxis errors. Ann Surg 250:10–16CrossRefPubMed
28.
go back to reference Ciofi degli Atti M, Spila Alegiani S, Raschetti R, Arace P, Giusti A, Spiazzi R, Raponi M, Group AS (2015) Surgical antibiotic prophylaxis in children: adherence to indication, choice of agent, timing, and duration. Eur J Clin Pharmacol 71:483–488CrossRefPubMed Ciofi degli Atti M, Spila Alegiani S, Raschetti R, Arace P, Giusti A, Spiazzi R, Raponi M, Group AS (2015) Surgical antibiotic prophylaxis in children: adherence to indication, choice of agent, timing, and duration. Eur J Clin Pharmacol 71:483–488CrossRefPubMed
29.
go back to reference Haynes AB, Weiser TG, Berry WR, Lipsitz SR, Breizat AH, Dellinger EP, Herbosa T, Joseph S, Kibatala PL, Lapitan MC, Merry AF, Moorthy K, Reznick RK, Taylor B, Gawande AA, Safe Surgery Saves Lives Study G (2009) A surgical safety checklist to reduce morbidity and mortality in a global population. N Engl J Med 360:491–499CrossRefPubMed Haynes AB, Weiser TG, Berry WR, Lipsitz SR, Breizat AH, Dellinger EP, Herbosa T, Joseph S, Kibatala PL, Lapitan MC, Merry AF, Moorthy K, Reznick RK, Taylor B, Gawande AA, Safe Surgery Saves Lives Study G (2009) A surgical safety checklist to reduce morbidity and mortality in a global population. N Engl J Med 360:491–499CrossRefPubMed
30.
go back to reference Oszvald A, Vatter H, Byhahn C, Seifert V, Guresir E (2012) “Team time-out” and surgical safety-experiences in 12,390 neurosurgical patients. Neurosurg Focus 33:E6CrossRefPubMed Oszvald A, Vatter H, Byhahn C, Seifert V, Guresir E (2012) “Team time-out” and surgical safety-experiences in 12,390 neurosurgical patients. Neurosurg Focus 33:E6CrossRefPubMed
31.
go back to reference Tacconelli E, Cataldo MA, Albanese A, Tumbarello M, Arduini E, Spanu T, Fadda G, Anile C, Maira G, Federico G, Cauda R (2008) Vancomycin versus cefazolin prophylaxis for cerebrospinal shunt placement in a hospital with a high prevalence of meticillin-resistant Staphylococcus aureus. J Hosp Infect 69:337–344CrossRefPubMed Tacconelli E, Cataldo MA, Albanese A, Tumbarello M, Arduini E, Spanu T, Fadda G, Anile C, Maira G, Federico G, Cauda R (2008) Vancomycin versus cefazolin prophylaxis for cerebrospinal shunt placement in a hospital with a high prevalence of meticillin-resistant Staphylococcus aureus. J Hosp Infect 69:337–344CrossRefPubMed
32.
go back to reference Lietard C, Thebaud V, Besson G, Lejeune B (2008) Risk factors for neurosurgical site infections: an 18-month prospective survey. J Neurosurg 109:729–734CrossRefPubMed Lietard C, Thebaud V, Besson G, Lejeune B (2008) Risk factors for neurosurgical site infections: an 18-month prospective survey. J Neurosurg 109:729–734CrossRefPubMed
33.
go back to reference Whitby M, Johnson BC, Atkinson RL, Stuart G (2000) The comparative efficacy of intravenous cefotaxime and trimethoprim/sulfamethoxazole in preventing infection after neurosurgery: a prospective, randomized study. Brisbane Neurosurgical Infection Group. Br J Neurosurg 14:13–18CrossRefPubMed Whitby M, Johnson BC, Atkinson RL, Stuart G (2000) The comparative efficacy of intravenous cefotaxime and trimethoprim/sulfamethoxazole in preventing infection after neurosurgery: a prospective, randomized study. Brisbane Neurosurgical Infection Group. Br J Neurosurg 14:13–18CrossRefPubMed
34.
go back to reference Valentini LG, Casali C, Chatenoud L, Chiaffarino F, Uberti-Foppa C, Broggi G (2008) Surgical site infections after elective neurosurgery: a survey of 1747 patients. Neurosurgery 62:88–95 discussion 95-86CrossRefPubMed Valentini LG, Casali C, Chatenoud L, Chiaffarino F, Uberti-Foppa C, Broggi G (2008) Surgical site infections after elective neurosurgery: a survey of 1747 patients. Neurosurgery 62:88–95 discussion 95-86CrossRefPubMed
35.
go back to reference Barker FG 2nd (2002) Efficacy of prophylactic antibiotic therapy in spinal surgery: a meta-analysis. Neurosurgery 51:391–400 discussion 400-391CrossRefPubMed Barker FG 2nd (2002) Efficacy of prophylactic antibiotic therapy in spinal surgery: a meta-analysis. Neurosurgery 51:391–400 discussion 400-391CrossRefPubMed
36.
go back to reference Barker FG 2nd (2007) Efficacy of prophylactic antibiotics against meningitis after craniotomy: a meta-analysis. Neurosurgery 60:887–894 discussion 887–894CrossRefPubMed Barker FG 2nd (2007) Efficacy of prophylactic antibiotics against meningitis after craniotomy: a meta-analysis. Neurosurgery 60:887–894 discussion 887–894CrossRefPubMed
37.
go back to reference Holloway KL, Smith KW, Wilberger JE Jr, Jemsek JG, Giguere GC, Collins JJ (1996) Antibiotic prophylaxis during clean neurosurgery: a large, multicenter study using cefuroxime. Clin Ther 18:84–94CrossRefPubMed Holloway KL, Smith KW, Wilberger JE Jr, Jemsek JG, Giguere GC, Collins JJ (1996) Antibiotic prophylaxis during clean neurosurgery: a large, multicenter study using cefuroxime. Clin Ther 18:84–94CrossRefPubMed
38.
go back to reference Korinek AM (1997) Risk factors for neurosurgical site infections after craniotomy: a prospective multicenter study of 2944 patients. The French study Group of Neurosurgical Infections, the SEHP, and the C-CLIN Paris-Nord. Service Epidemiologie hygiene et prevention. Neurosurgery 41:1073–1079 discussion 1079-1081CrossRefPubMed Korinek AM (1997) Risk factors for neurosurgical site infections after craniotomy: a prospective multicenter study of 2944 patients. The French study Group of Neurosurgical Infections, the SEHP, and the C-CLIN Paris-Nord. Service Epidemiologie hygiene et prevention. Neurosurgery 41:1073–1079 discussion 1079-1081CrossRefPubMed
39.
go back to reference Scher KS (1997) Studies on the duration of antibiotic administration for surgical prophylaxis. Am Surg 63:59–62PubMed Scher KS (1997) Studies on the duration of antibiotic administration for surgical prophylaxis. Am Surg 63:59–62PubMed
40.
go back to reference Ifeachor AP, Nichols KR, Morris JL, Cox EG, Smith JL, Sinclair EA (2015) Antimicrobial prophylaxis for external ventricular drains in pediatric neurosurgical patients. Paediatr Drugs 17:239–244CrossRefPubMed Ifeachor AP, Nichols KR, Morris JL, Cox EG, Smith JL, Sinclair EA (2015) Antimicrobial prophylaxis for external ventricular drains in pediatric neurosurgical patients. Paediatr Drugs 17:239–244CrossRefPubMed
41.
go back to reference Raskin JS, Hansen D, Mohan A, Pan IW, Curry DJ, Lam S (2017) Perioperative antibiotic use in vagus nerve stimulator implantation: a clinical series. Childs Nerv Syst 33:801–804CrossRefPubMed Raskin JS, Hansen D, Mohan A, Pan IW, Curry DJ, Lam S (2017) Perioperative antibiotic use in vagus nerve stimulator implantation: a clinical series. Childs Nerv Syst 33:801–804CrossRefPubMed
42.
go back to reference Somma T, Maraolo AE, Esposito F, Cavallo LM, Tosone G, Orlando R, Cappabianca P (2015) Efficacy of ultra-short single agent regimen antibiotic chemo-prophylaxis in reducing the risk of meningitis in patients undergoing endoscopic endonasal transsphenoidal surgery. Clin Neurol Neurosurg 139:206–209CrossRefPubMed Somma T, Maraolo AE, Esposito F, Cavallo LM, Tosone G, Orlando R, Cappabianca P (2015) Efficacy of ultra-short single agent regimen antibiotic chemo-prophylaxis in reducing the risk of meningitis in patients undergoing endoscopic endonasal transsphenoidal surgery. Clin Neurol Neurosurg 139:206–209CrossRefPubMed
43.
go back to reference Liu W, Neidert MC, Groen RJ, Woernle CM, Grundmann H (2014) Third-generation cephalosporins as antibiotic prophylaxis in neurosurgery: what’s the evidence? Clin Neurol Neurosurg 116:13–19CrossRefPubMed Liu W, Neidert MC, Groen RJ, Woernle CM, Grundmann H (2014) Third-generation cephalosporins as antibiotic prophylaxis in neurosurgery: what’s the evidence? Clin Neurol Neurosurg 116:13–19CrossRefPubMed
44.
go back to reference Haines SJ, Walters BC (1994) Antibiotic prophylaxis for cerebrospinal fluid shunts: a metanalysis. Neurosurgery 34:87–92PubMed Haines SJ, Walters BC (1994) Antibiotic prophylaxis for cerebrospinal fluid shunts: a metanalysis. Neurosurgery 34:87–92PubMed
45.
go back to reference Langley JM, LeBlanc JC, Drake J, Milner R (1993) Efficacy of antimicrobial prophylaxis in placement of cerebrospinal fluid shunts: meta-analysis. Clin Infect Dis 17:98–103CrossRefPubMed Langley JM, LeBlanc JC, Drake J, Milner R (1993) Efficacy of antimicrobial prophylaxis in placement of cerebrospinal fluid shunts: meta-analysis. Clin Infect Dis 17:98–103CrossRefPubMed
46.
go back to reference van Lindert EJ, Bilsen MV, Flier MV, Kolwijck E, Delye H, Oever JT (2018) Topical vancomycin reduces the cerebrospinal fluid shunt infection rate: a retrospective cohort study. PLoS One 13:e0190249CrossRefPubMedPubMedCentral van Lindert EJ, Bilsen MV, Flier MV, Kolwijck E, Delye H, Oever JT (2018) Topical vancomycin reduces the cerebrospinal fluid shunt infection rate: a retrospective cohort study. PLoS One 13:e0190249CrossRefPubMedPubMedCentral
47.
go back to reference Kestle JR, Riva-Cambrin J, Wellons JC 3rd, Kulkarni AV, Whitehead WE, Walker ML, Oakes WJ, Drake JM, Luerssen TG, Simon TD, Holubkov R, Hydrocephalus Clinical Research N (2011) A standardized protocol to reduce cerebrospinal fluid shunt infection: the hydrocephalus clinical research network quality improvement initiative. J Neurosurg Pediatr 8:22–29CrossRefPubMedPubMedCentral Kestle JR, Riva-Cambrin J, Wellons JC 3rd, Kulkarni AV, Whitehead WE, Walker ML, Oakes WJ, Drake JM, Luerssen TG, Simon TD, Holubkov R, Hydrocephalus Clinical Research N (2011) A standardized protocol to reduce cerebrospinal fluid shunt infection: the hydrocephalus clinical research network quality improvement initiative. J Neurosurg Pediatr 8:22–29CrossRefPubMedPubMedCentral
48.
go back to reference Kestle JR, Holubkov R, Douglas Cochrane D, Kulkarni AV, Limbrick DD Jr, Luerssen TG, Jerry Oakes W, Riva-Cambrin J, Rozzelle C, Simon TD, Walker ML, Wellons JC 3rd, Browd SR, Drake JM, Shannon CN, Tamber MS, Whitehead WE, Hydrocephalus Clinical Research N (2016) A new hydrocephalus clinical research network protocol to reduce cerebrospinal fluid shunt infection. J Neurosurg Pediatr 17:391–396CrossRefPubMed Kestle JR, Holubkov R, Douglas Cochrane D, Kulkarni AV, Limbrick DD Jr, Luerssen TG, Jerry Oakes W, Riva-Cambrin J, Rozzelle C, Simon TD, Walker ML, Wellons JC 3rd, Browd SR, Drake JM, Shannon CN, Tamber MS, Whitehead WE, Hydrocephalus Clinical Research N (2016) A new hydrocephalus clinical research network protocol to reduce cerebrospinal fluid shunt infection. J Neurosurg Pediatr 17:391–396CrossRefPubMed
49.
go back to reference Klimo P Jr, Van Poppel M, Thompson CJ, Baird LC, Duhaime AC, Flannery AM, Pediatric Hydrocephalus Systematic R, Evidence-Based Guidelines Task F (2014) Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 6: preoperative antibiotics for shunt surgery in children with hydrocephalus: a systematic review and meta-analysis. J Neurosurg Pediatr 14(Suppl 1):44–52CrossRefPubMed Klimo P Jr, Van Poppel M, Thompson CJ, Baird LC, Duhaime AC, Flannery AM, Pediatric Hydrocephalus Systematic R, Evidence-Based Guidelines Task F (2014) Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 6: preoperative antibiotics for shunt surgery in children with hydrocephalus: a systematic review and meta-analysis. J Neurosurg Pediatr 14(Suppl 1):44–52CrossRefPubMed
50.
go back to reference Parker SL, McGirt MJ, Murphy JA, Megerian JT, Stout M, Engelhart L (2015) Comparative effectiveness of antibiotic-impregnated shunt catheters in the treatment of adult and pediatric hydrocephalus: analysis of 12,589 consecutive cases from 287 US hospital systems. J Neurosurg 122:443–448CrossRefPubMed Parker SL, McGirt MJ, Murphy JA, Megerian JT, Stout M, Engelhart L (2015) Comparative effectiveness of antibiotic-impregnated shunt catheters in the treatment of adult and pediatric hydrocephalus: analysis of 12,589 consecutive cases from 287 US hospital systems. J Neurosurg 122:443–448CrossRefPubMed
51.
go back to reference Ratilal B, Costa J, Sampaio C (2008) Antibiotic prophylaxis for surgical introduction of intracranial ventricular shunts: a systematic review. J Neurosurg Pediatr 1:48–56CrossRefPubMed Ratilal B, Costa J, Sampaio C (2008) Antibiotic prophylaxis for surgical introduction of intracranial ventricular shunts: a systematic review. J Neurosurg Pediatr 1:48–56CrossRefPubMed
52.
go back to reference Xu H, Hu F, Hu H, Sun W, Jiao W, Li R, Lei T (2016) Antibiotic prophylaxis for shunt surgery of children: a systematic review. Childs Nerv Syst 32:253–258CrossRefPubMed Xu H, Hu F, Hu H, Sun W, Jiao W, Li R, Lei T (2016) Antibiotic prophylaxis for shunt surgery of children: a systematic review. Childs Nerv Syst 32:253–258CrossRefPubMed
53.
go back to reference Biyani N, Grisaru-Soen G, Steinbok P, Sgouros S, Constantini S (2006) Prophylactic antibiotics in pediatric shunt surgery. Childs Nerv Syst 22:1465–1471CrossRefPubMed Biyani N, Grisaru-Soen G, Steinbok P, Sgouros S, Constantini S (2006) Prophylactic antibiotics in pediatric shunt surgery. Childs Nerv Syst 22:1465–1471CrossRefPubMed
54.
go back to reference Jaeger W, Lee S, Vineet D, Keil A, Agarwal N, Rao S (2017) Ventriculoperitoneal shunts in neonates: a retrospective study of outcomes with antibiotic-impregnated catheters and a modified peri-operative antibiotic protocol. Br J Neurosurg 31:672–676CrossRefPubMed Jaeger W, Lee S, Vineet D, Keil A, Agarwal N, Rao S (2017) Ventriculoperitoneal shunts in neonates: a retrospective study of outcomes with antibiotic-impregnated catheters and a modified peri-operative antibiotic protocol. Br J Neurosurg 31:672–676CrossRefPubMed
55.
go back to reference Govender ST, Nathoo N, van Dellen JR (2003) Evaluation of an antibiotic-impregnated shunt system for the treatment of hydrocephalus. J Neurosurg 99:831–839CrossRefPubMed Govender ST, Nathoo N, van Dellen JR (2003) Evaluation of an antibiotic-impregnated shunt system for the treatment of hydrocephalus. J Neurosurg 99:831–839CrossRefPubMed
56.
go back to reference Sorar M, Er U, Ozisik P, Ozeren E, Simsek S (2014) The impact of antibiotic-impregnated catheters on ventriculoperitoneal shunt infection. Turk J Med Sci 44:393–396CrossRefPubMed Sorar M, Er U, Ozisik P, Ozeren E, Simsek S (2014) The impact of antibiotic-impregnated catheters on ventriculoperitoneal shunt infection. Turk J Med Sci 44:393–396CrossRefPubMed
57.
go back to reference Weiss K, Simon A, Graf N, Schope J, Oertel J, Linsler S (2017) Clinical practice audit concerning antimicrobial prophylaxis in paediatric neurosurgery: results from a German paediatric oncology unit. Childs Nerv Syst 33:159–169CrossRefPubMed Weiss K, Simon A, Graf N, Schope J, Oertel J, Linsler S (2017) Clinical practice audit concerning antimicrobial prophylaxis in paediatric neurosurgery: results from a German paediatric oncology unit. Childs Nerv Syst 33:159–169CrossRefPubMed
Metadata
Title
Prophylactic antibiotics in pediatric neurological surgery
Authors
Friederike Knerlich-Lukoschus
Martina Messing-Jünger
Publication date
01-10-2018
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 10/2018
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-018-3864-0

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