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Lasers in Medical Science
Published in: Lasers in Medical Science 2/2019

01-03-2019 | Brief Report

Promotion of wound healing through low-fluence ablative fractional laser treatment in diabetic mice

Authors: Han Na Lee, Jung Min Bae, Bon Cheol Leo Goo, Young Min Park

Published in: Lasers in Medical Science | Issue 2/2019

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Abstract

Chronic ulcers are a significant cause of morbidity in diabetic patients, which can greatly affect a patient’s quality of life. While numerous methods have been developed to promote and enhance wound healing in diabetic patients, a convenient, effective treatment for diabetic ulcers has yet to be established. Here, we demonstrate the promotion of wound healing using a low-fluence (2 mJ/spot) ablative fractional laser (AFL) treatment in diabetic mice. Treatment was shown to confer increases in mRNA expression and in protein abundance of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), along with decreases in mRNA expression and protein abundance of transforming growth factor beta (TGF-β). Taken together, these results suggest that low-fluence AFL treatment can be used to promote healing in chronic diabetic wounds.
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Metadata
Title
Promotion of wound healing through low-fluence ablative fractional laser treatment in diabetic mice
Authors
Han Na Lee
Jung Min Bae
Bon Cheol Leo Goo
Young Min Park
Publication date
01-03-2019
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 2/2019
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-018-2559-9

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