Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Intensive Care Medicine
Published in: Intensive Care Medicine 4/2020

01-04-2020 | Letter

Prolonged elevation of plasma HMGB1 is associated with cognitive impairment in intensive care unit survivors

Authors: Emily Brück, Julie Lasselin, Ulf Andersson, Peter V. Sackey, Peder S. Olofsson, The HICUS study group

Published in: Intensive Care Medicine | Issue 4/2020

Login to get access

Excerpt

Dear Editor, …
Appendix
Available only for authorised users
Literature
1.
Wolters AE, Slooter AJ, van der Kooi AW, van Dijk D (2013) Cognitive impairment after intensive care unit admission: a systematic review. Intensive Care Med 39(3):376–386CrossRef
2.
Chavan SS, Huerta PT, Robbiati S, Valdes-Ferrer SI, Ochani M, Dancho M, et al (2012) HMGB1 mediates cognitive impairment in sepsis survivors. Mol Med 18:930–7
3.
Okuma Y, Wake H, Teshigawara K, Takahashi Y, Hishikawa T, Yasuhara T et al (2019) Anti-high mobility group box 1 antibody therapy may prevent cognitive dysfunction after traumatic brain injury. World Neurosurg. 122:e864–e871CrossRef
4.
Zhang J, Takahashi HK, Liu K, Wake H, Liu R, Maruo T et al (2011) Anti-high mobility group box-1 monoclonal antibody protects the blood-brain barrier from ischemia-induced disruption in rats. Stroke 42(5):1420–1428CrossRef
5.
Andersson U, Yang H, Harris H (2018) Extracellular HMGB1 as a therapeutic target in inflammatory diseases. Expert Opin Ther Targets. 22(3):263–277CrossRef
Metadata
Title
Prolonged elevation of plasma HMGB1 is associated with cognitive impairment in intensive care unit survivors
Authors
Emily Brück
Julie Lasselin
Ulf Andersson
Peter V. Sackey
Peder S. Olofsson
The HICUS study group
Publication date
01-04-2020
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 4/2020
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-020-05941-7

Other articles of this Issue 4/2020

Intensive Care Medicine 4/2020 Go to the issue

Less is more in Intensive Care

Less empiric broad-spectrum antibiotics is more in the ICU

Correspondence

Leptospirosis: different presentation and mortality in tropical and non-tropical areas

Correction

Correction to: Use of combined cardiac and lung ultrasound to predict weaning failure in elderly, high-risk cardiac patients: a pilot study

Letter

Capillary refill time status could identify different clinical phenotypes among septic shock patients fulfilling Sepsis-3 criteria: a post hoc analysis of ANDROMEDA-SHOCK trial

Letter

Renin aldosterone vasopressin and copeptin kinetics in patients with septic shock, a post-hoc Hyper2S randomized trial analysis

Understanding the Disease

Why we need safer anticoagulant strategies for patients on short-term percutaneous mechanical circulatory support