Top

Published in:

01-01-2015 | Original Article

Projections from the central amygdaloid nucleus to the precuneiform nucleus in the mouse

Authors: Huazheng Liang, Charles Watson, George Paxinos

Published in: Brain Structure and Function | Issue 1/2015

Abstract

The mouse precuneiform nucleus has been proposed as the midbrain locomotion center, a function ascribed to its caudal neighbor, cuneiform nucleus, in the rat, cat and other species. The present study investigated the projections from the central amygdaloid nucleus to the precuneiform nucleus in the mouse using retrograde tracer injections (fluoro-gold) into the precuneiform nucleus and anterograde tracer injections (biotinylated dextran amine) into the central amygdaloid nucleus. The entire central amygdaloid nucleus except the rostral pole had retrogradely labeled neurons, especially in the middle portion where labeled neurons were densely packed. Anterogradely labeled amygdaloid fibers approached the precuneiform nucleus from the area ventrolateral to it and terminated in the entire precuneiform nucleus. Labeled fibers were also found in laminae 5 and 6 in the upper cervical cord on the ipsilateral side. The present study is the first demonstration of projections from the central amygdaloid nucleus to the precuneiform nucleus. This projection may underpin the role of the precuneiform nucleus in the modulation of the cardiovascular activity.

Beck CH, Fibiger HC (1995) Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: with and without diazepam pretreatment. J Neurosci 15:709–720PubMed

Cahill L, Haier RJ, Fallon J, Alkire MT, Tang C, Keator D, Wu J, McGaugh JL (1996) Amygdala activity at encoding correlated with long-term, free recall of emotional information. Proc Natl Acad Sci 93:8016–8021PubMedCentralPubMedCrossRef

Campeau S, Hayward MD, Hope BT, Rosen JB, Nestler EJ, Davis M (1991) Induction of the c-fos proto-oncogene in the rat amygdala during conditioned and unconditioned fear. Brain Res 565:349–352PubMedCrossRef

Carlson JD, Iacono RP, Maeda G (2004) Nociceptive excited and inhibited neurons within the pedunculopontine tegmental nucleus and cuneiform nucleus. Brain Res 1013(2):182–187PubMedCrossRef

Coles SK, Iles JF, Nicolopoulos-Stournaras S (1989) The mesencephalic centre controlling locomotion in the rat. Neuroscience 28:149–157PubMedCrossRef

Ebert U, Ostwald J (1991) The mesencephalic locomotor region is activated during the auditory startle response of the unrestrained rat. Brain Res 565:209–217PubMedCrossRef

Ferreira-Netto C, Borelli KG, Brandão ML (2007) Distinct fos expression in the brain following freezing behavior elicited by stimulation with NMDA of the ventral or dorsal inferior colliculus. Exp Neurol 204:693–704PubMedCrossRef

Garcia-Rill E, Skinner RD, Gilmore S, Owing R (1983) Connections of the mesencephalic locomotor region (MLR) II. Afferents and efferents. Brain Res Bull 10:63–71PubMedCrossRef

Grillner S, Zangger P (1975) How detailed is the central pattern generation for locomotion? Brain Res 88:367–371PubMedCrossRef

Haghparast A, Soltani-Hekmat A, Khani A, Komaki A (2007) Role of glutamatergic receptors located in the nucleus raphe magnus on antinociceptive effect of morphine microinjected into the nucleus cuneiformis of rat. Neurosci Lett 427:44–49PubMedCrossRef

Haghparast A, Ordikhani-Seyedlar M, Ziaei M (2008) Electrolytic lesion of the nucleus raphe magnus reduced the antinociceptive effects of bilateral morphine microinjected into the nucleus cuneiform is in rats. Neurosci Lett 438:351–355PubMedCrossRef

Hamann SB, Ely TD, Grafton ST, Kilts CD (1999) Amygdala activity related to enhanced memory for pleasant and aversive stimuli. Nat Neurosci 2:289–293PubMedCrossRef

Jell RM, Elliott C, Jordan LM (1985) Initiation of locomotion from the mesencephalic locomotor region: effects of selective brainstem lesions. Brain Res 328:121–128PubMedCrossRef

Korte SM, Jaarsma D, Luiten PG, Bohus B (1992) Mesencephalic cuneiform nucleus and its ascending and descending projections serve stress-related cardiovascular responses in the rat. J Auton Nerv Syst 41:157–176PubMedCrossRef

Lam W, Verberne AJ (1997) Cuneiform nucleus stimulation-induced sympathoexcitation: role of adrenoceptors, excitatory amino acid and serotonin receptors in rat spinal cord. Brain Res 757:191–201PubMedCrossRef

Lam W, Gundlach AL, Verberne AJ (1996) Increased nerve growth factor inducible-A gene and c-fos messenger RNA levels in the rat midbrain and hindbrain associated with the cardiovascular response to electrical stimulation of the mesencephalic cuneiform nucleus. Neuroscience 71:193–211PubMedCrossRef

Lam W, Gundlach AL, Verberne AJ (1997) Neuronal activation in the forebrain following electrical stimulation of the cuneiform nucleus in the rat: hypothalamic expression of c-fos and NGFI-A messenger RNA. Neuroscience 78:1069–1085PubMedCrossRef

Lamprea MR, Cardenas FP, Vianna DM, Castilho VM, Cruz-Morales SE, Brandão ML (2002) The distribution of fos immunoreactivity in rat brain following freezing and escape responses elicited by electrical stimulation of the inferior colliculus. Brain Res 950:186–194PubMedCrossRef

Liang HZ, Paxinos G, Watson C (2011) Projections from the brain to the spinal cord in the mouse. Brain Struct Funct 215:159–186PubMedCrossRef

Liang H, Paxinos G, Watson C (2012) Spinal projections from the presumptive midbrain locomotor region in the mouse. Brain Struct Funct 217:211–219PubMedCrossRef

Morris JS, Ohman A, Dolan RJ (1998) Conscious and unconscious emotional learning in the human amygdala. Nature 393:467–470PubMedCrossRef

Paxinos G, Franklin KBJ (2013) The mouse brain in stereotaxic coordinates, 4th edn. Elsevier Academic Press, San Diego

Phan KL, Wager T, Taylor SF, Liberzon I (2002) Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in pet and fmri. Neuroimage 16:331–348PubMedCrossRef

Price JL, Amaral DG (1981) An autoradiographic study of the projections of the central nucleus of the monkey amygdala. J Neurosci 1:1242–1259PubMed

Shammah-Lagnado SJ, Alheid GF, Heimer L (1996) Efferent connections of the caudal part of the globus pallidus in the rat. J Comp Neurol 376:489–507PubMedCrossRef

Skinner RD, Garcia-Rill E (1984) The mesencephalic locomotor region (MLR) in the rat. Brain Res 323:385–389PubMedCrossRef

Stanciu M, Radulovic J, Spiess J (2001) Phosphorylation cAMP response element binding protein in the mouse brain after fear conditioning: relationship to fos production. Mol Brain Res 94:15–24PubMedCrossRef

Zemlan FP, Behbehani MM (1988) Nucleus cuneiformis and pain modulation: anatomy and behavioral pharmacology. Brain Res 453(1–2):89–102PubMedCrossRef

Title: Projections from the central amygdaloid nucleus to the precuneiform nucleus in the mouse
Authors: Huazheng Liang
Charles Watson
George Paxinos
Publication date: 01-01-2015
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 1/2015
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-013-0653-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Projections from the central amygdaloid nucleus to the precuneiform nucleus in the mouse

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2015

Discordant cerebral lateralisation for verbal fluency is not an artefact of attention: evidence from MzHd twins

Exclusive neuronal expression of SUCLA2 in the human brain

Multivariate classification of social anxiety disorder using whole brain functional connectivity

Not on speaking terms: hallucinations and structural network disconnectivity in schizophrenia

The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes

Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy