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01-07-2018 | Original Article

Progressive symptom-associated prefrontal volume loss occurs in first-episode schizophrenia but not in affective psychosis

Authors: Toshiyuki Ohtani, Elisabetta del Re, James J. Levitt, Margaret Niznikiewicz, Jun Konishi, Takeshi Asami, Toshiro Kawashima, Tomohide Roppongi, Paul G. Nestor, Martha E. Shenton, Dean F. Salisbury, Robert W. McCarley

Published in: Brain Structure and Function | Issue 6/2018

Abstract

Although smaller gray matter volumes (GMV) in the prefrontal cortex (PFC) in schizophrenia and bipolar disorder have been reported cross-sectionally, there are, to our knowledge, no reports of longitudinal comparisons using manually drawn, gyrally based ROI, and their associations with symptoms. The object of this study was to determine whether first-episode schizophrenia (FESZ) and first-episode affective psychosis (FEAFF) patients show initial and progressive PFC GMV reduction in bilateral frontal pole, superior frontal gyrus (SFG), middle frontal gyrus (MFG), and inferior frontal gyrus (IFG) and examine their symptom associations. Twenty-one FESZ, 24 FEAFF and 23 healthy control subjects (HC) underwent 1.5T MRI with follow-up imaging on the same scanner ~ 1.5 years later. Groups were strikingly different in progressive GMV loss. FESZ showed significant progressive GMV loss in the left SFG, bilateral MFG, and bilateral IFG. In addition, left MFG and/or IFG GMV loss was associated with worsening of withdrawal–retardation and total BPRS symptoms scores. In contrast, FEAFF showed no significant difference in GMV compared with HC, either cross-sectionally or longitudinally. Of note, FreeSurfer run on the same images showed no significant changes longitudinally.

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Title: Progressive symptom-associated prefrontal volume loss occurs in first-episode schizophrenia but not in affective psychosis
Authors: Toshiyuki Ohtani
Elisabetta del Re
James J. Levitt
Margaret Niznikiewicz
Jun Konishi
Takeshi Asami
Toshiro Kawashima
Tomohide Roppongi
Paul G. Nestor
Martha E. Shenton
Dean F. Salisbury
Robert W. McCarley
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 6/2018
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-018-1634-0

At a glance: The STEP trials

Springer Medicine

Progressive symptom-associated prefrontal volume loss occurs in first-episode schizophrenia but not in affective psychosis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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