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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 11/2018

01-10-2018 | Thoracic Oncology

Prognostic Value of Preoperative Systemic Immunoinflammatory Measures in Patients with Esophageal Cancer

Authors: Yusuke Ishibashi, MD, Hironori Tsujimoto, MD, PhD, Shuichi Hiraki, MD, Isao Kumano, MD, Yoshihisa Yaguchi, MD, Hiroyuki Horiguchi, MD, Shinsuke Nomura, MD, Nozomi Ito, MD, Eiji Shinto, MD, Suefumi Aosasa, MD, Junji Yamamoto, MD, PhD, Hideki Ueno, MD, PhD

Published in: Annals of Surgical Oncology | Issue 11/2018

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Abstract

Background

It is reported that several systemic immunoinflammatory measures, including systemic immune-inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, and C-reactive protein (CRP)-to-albumin ratio (CAR), are associated with survival in patients with various types of cancer.

Objective

The aim of the present study was to clear which systemic immunoinflammatory measures had the greatest prognostic values. In addition, we examined which component had the greatest prognostic power in patients with esophageal cancer.

Methods

Preoperative systemic immunoinflammatory measures were evaluated in 143 patients undergoing esophageal resection for esophageal cancer from 2009 to 2014. Univariate and multivariate analyses were performed to determine the prognostic significance of these markers. Receiver operating characteristic (ROC) curves were plotted, and the area under the ROC curves (AUROCs) were compared to verify the accuracy of each measure in predicting overall survival (OS).

Results

In univariate analysis, preoperative SII, NLR, and CAR were the predictors of OS in patients who underwent esophagectomy for esophageal cancer (p < 0.05, respectively), whereas in multivariate analysis, CAR and pathological tumor depth were the significant predictors of OS (hazard ratio [HR] 1.994, p = 0.03 vs. HR 1.967, p = 0.02, respectively). According to AUROC, the CRP (0.66) and albumin levels (0.66) were more important systemic immunoinflammatory measures than neutrophil (0.58), lymphocyte (0.63), and platelet (0.56) levels.

Conclusion

Among systemic immunoinflammatory measures, CAR was the most significant predictor of OS in patients with esophageal cancer. CRP and albumin levels were more important components of systemic immunoinflammatory measures.
Appendix
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Metadata
Title
Prognostic Value of Preoperative Systemic Immunoinflammatory Measures in Patients with Esophageal Cancer
Authors
Yusuke Ishibashi, MD
Hironori Tsujimoto, MD, PhD
Shuichi Hiraki, MD
Isao Kumano, MD
Yoshihisa Yaguchi, MD
Hiroyuki Horiguchi, MD
Shinsuke Nomura, MD
Nozomi Ito, MD
Eiji Shinto, MD
Suefumi Aosasa, MD
Junji Yamamoto, MD, PhD
Hideki Ueno, MD, PhD
Publication date
01-10-2018
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 11/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6651-y

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