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World Journal of Urology

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01-02-2017 | Original Article

Prognostic value of preoperative NLR, dNLR, PLR and CRP in surgical renal cell carcinoma patients

Authors: Hong Hu, Xiajuan Yao, Xiangcheng Xie, Xia Wu, Chuanming Zheng, Wenkai Xia, Shenglin Ma

Published in: World Journal of Urology | Issue 2/2017

Abstract

Background

Emerging evidences indicate that inflammation plays a crucial role in carcinogenesis and tumor progression. Inflammatory response biomarkers are recognized as promising prognostic factors for improving predictive accuracy in renal cell carcinoma (RCC). We aimed to evaluate the prognostic significance of preoperative neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR) and serum C-reactive protein (CRP) in RCC.

Methods

484 surgical RCC patients were enrolled from 2006 to 2010 in this study. Receiver operating curve (ROC) was applied to assess the optimal cutoff levels for four biomarkers, and the prognostic values were determined by Kaplan–Meier curve, univariate and multivariate COX regression models. The predictive accuracy was evaluated by concordance index (c-index).

Results

The median follow-up duration after surgical resection was 36 months. The optimal cutoff levels were 2.78 for NLR, 2.05 for dNLR, 185 for PLR and 5.1 for CRP by ROC curves analysis. Elevated NLR, dNLR, PLR and CRP were significantly correlated with worse overall survival (OS). Multivariate analysis showed that elevated NLR was an independent risk factor for OS, and NLR was superior to dNLR, PLR and CRP based on hazard ratio (HR 2.10, 95 % CI 1.21–3.64, P = 0.008). Additionally, the nomogram could more effectively work in predicting OS (c-index: 0.749) in surgical RCC patients.

Conclusion

Pre-operation NLR can be considered as a potential prognostic biomarker in patients with RCC who underwent surgical resection.

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Title: Prognostic value of preoperative NLR, dNLR, PLR and CRP in surgical renal cell carcinoma patients
Authors: Hong Hu
Xiajuan Yao
Xiangcheng Xie
Xia Wu
Chuanming Zheng
Wenkai Xia
Shenglin Ma
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: World Journal of Urology / Issue 2/2017
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-016-1864-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Prognostic value of preoperative NLR, dNLR, PLR and CRP in surgical renal cell carcinoma patients

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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