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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 1/2015

01-01-2015 | Breast Oncology

Prognostic Value of Extracapsular Invasion of Axillary Lymph Nodes Combined with Peritumoral Vascular Invasion in Patients with Breast Cancer

Authors: Reina Yajima, MD, Takaaki Fujii, MD, PhD, Yasuhiro Yanagita, MD, PhD, Tomomi Fujisawa, MD, PhD, Takeshi Miyamoto, MD, PhD, Tomoko Hirakata, MD, PhD, Soichi Tsutsumi, MD, PhD, Misa Iijima, MD, PhD, Hiroyuki Kuwano, MD, PhD

Published in: Annals of Surgical Oncology | Issue 1/2015

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Abstract

Background

Extracapsular invasion (ECI) of metastatic axillary lymph nodes has been associated with aggressive nodal disease but its prognostic role in breast cancer is unclear. The present study evaluated nodal ECI as a predictor of breast cancer recurrence.

Methods

We evaluated 154 women with histologically proven node-positive breast cancer who were diagnosed with invasive ductal carcinoma, and investigated the relationships between ECI and recurrences and other clinicopathological factors, particularly vascular invasion and the number of lymph node metastases.

Results

The presence of ECI at positive nodes was significantly associated with the number of positive nodes, and with disease recurrence and survival in univariate (but not multivariate) analysis. Interestingly, all ECI+ patients with distant metastases in our series had peritumoral vascular invasion (PVI), which may have reflected systemic disease; ECI with PVI of the primary tumor strongly predicted recurrent disease and shorter survival.

Conclusion

ECI of axillary metastases combined with PVI indicates high tumor aggressiveness. Patients with ECI and PVI may be considered for stronger adjuvant therapies because of their high risk for distant recurrences.
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Metadata
Title
Prognostic Value of Extracapsular Invasion of Axillary Lymph Nodes Combined with Peritumoral Vascular Invasion in Patients with Breast Cancer
Authors
Reina Yajima, MD
Takaaki Fujii, MD, PhD
Yasuhiro Yanagita, MD, PhD
Tomomi Fujisawa, MD, PhD
Takeshi Miyamoto, MD, PhD
Tomoko Hirakata, MD, PhD
Soichi Tsutsumi, MD, PhD
Misa Iijima, MD, PhD
Hiroyuki Kuwano, MD, PhD
Publication date
01-01-2015
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue 1/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-014-3941-x

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