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01-01-2016 | Original Article

Prognostic value of CXCL12 and CXCR4 in inoperable head and neck squamous cell carcinoma

Authors: Margret Rave-Fränk, Narges Tehrany, Dr. med. Julia Kitz, Martin Leu, Dr. med. Hanne Elisabeth Weber, Prof. Dr. med. Peter Burfeind, Prof. Dr. med. Henning Schliephake, Prof. Dr. med. Martin Canis, Prof. Dr Tim Beissbarth, Prof. Dr Holger Michael Reichardt, PD Dr. med. Hendrik Andreas Wolff

Published in: Strahlentherapie und Onkologie | Issue 1/2016

Abstract

Objective

The chemokine CXCL12 and its receptor CXCR4 can affect tumor growth, recurrence, and metastasis. We tested the hypothesis that the CXCL12 and CXCR4 expression influences the prognosis of patients with inoperable head and neck cancer treated with definite radiotherapy or chemoradiotherapy.

Methods

Formalin-fixed paraffin-embedded pretreatment tumor tissue from 233 patients with known HPV/p16^INK4A status was analyzed. CXCL12 and CXCR4 expressions were correlated with pretreatment parameters and survival data by univariate and multivariate Cox regression.

Results

CXCL12 was expressed in 43.3 % and CXCR4 in 66.1 % of the samples and both were correlated with HPV/p16^INK4A positivity. A high CXCL12 expression was associated with increased overall survival (p = 0.036), while a high CXCR4 expression was associated with decreased metastasis-free survival (p = 0.034).

Conclusion

A high CXCR4 expression could be regarded as a negative prognostic factor in head and neck cancer because it may foster metastatic spread. This may recommend CXCR4 as therapeutic target for combating head and neck cancer metastasis.

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Title: Prognostic value of CXCL12 and CXCR4 in inoperable head and neck squamous cell carcinoma
Authors: Margret Rave-Fränk
Narges Tehrany
Dr. med. Julia Kitz
Martin Leu
Dr. med. Hanne Elisabeth Weber
Prof. Dr. med. Peter Burfeind
Prof. Dr. med. Henning Schliephake
Prof. Dr. med. Martin Canis
Prof. Dr Tim Beissbarth
Prof. Dr Holger Michael Reichardt
PD Dr. med. Hendrik Andreas Wolff
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 1/2016
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-015-0892-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognostic value of CXCL12 and CXCR4 in inoperable head and neck squamous cell carcinoma

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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