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Open Access 01-12-2011 | Short report

Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back?

Authors: Stephanie E Combs, Stefan Rieken, Wolfgang Wick, Amir Abdollahi, Andreas von Deimling, Jürgen Debus, Christian Hartmann

Published in: Radiation Oncology | Issue 1/2011

Abstract

A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase (MGMT)-promoter methylation as well as isocitrate dehydrogenase (IDH)1-mutational status. Unexpectedly, overall survival or progression-free survival were not longer in the group with methylated MGMT-promoter as compared to patients without that methylation. IDH-1 mutations were significantly associated with increased overall survival.

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Title: Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back?
Authors: Stephanie E Combs
Stefan Rieken
Wolfgang Wick
Amir Abdollahi
Andreas von Deimling
Jürgen Debus
Christian Hartmann
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2011
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-6-115

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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