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Clinical Oral Investigations

Published in:

01-04-2018 | Original Article

Prognostic implication of NOTCH1 in early stage oral squamous cell cancer with occult metastases

Authors: Shan Wang, Haixia Fan, Jiankai Xu, Eryang Zhao

Published in: Clinical Oral Investigations | Issue 3/2018

Abstract

Objective

The objective of this study was to explore the prognostic value of cancer stem cell markers, namely CD133, NANOG, and NOTCH1, in early stage oral squamous cell carcinoma (OSCC).

Materials and methods

One hundred forty-four patients with early stage (cT1T2N0) OSCC were identified from a pre-existing database of patients with oral cancer. We examined the impact of the immunohistochemical expression of CD133, NANOG, and NOTCH1 in OSCC. Overall survival (OS) curves were calculated using the Kaplan–Meier method. Predictors of outcome were identified using multivariate analysis.

Results

We found that CD133, NANOG, and NOTCH1 were significantly associated with lymph node metastasis, and NOTCH1 was also significantly associated with depth of invasion and locoregional recurrence.

Conclusions

NOTCH1 was identified as an independent prognostic factor for OS.

Clinical relevance

NOTCH1 might prove to be a useful indicator for high-risk patients with occult metastases from early stage OSCC.

Available only for authorised users

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Title: Prognostic implication of NOTCH1 in early stage oral squamous cell cancer with occult metastases
Authors: Shan Wang
Haixia Fan
Jiankai Xu
Eryang Zhao
Publication date: 01-04-2018
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 3/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-017-2197-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognostic implication of NOTCH1 in early stage oral squamous cell cancer with occult metastases

Abstract

Objective

Materials and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusions

Clinical relevance

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