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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2015

01-12-2015 | Colorectal Cancer

Prognostic Impact of Histologic Type in Curatively Resected Stage IV Colorectal Cancer: A Japanese Multicenter Retrospective Study

Authors: Junichi Shibata, MD, Kazushige Kawai, MD, PhD, Takeshi Nishikawa, MD, PhD, Toshiaki Tanaka, MD, PhD, Junichiro Tanaka, MD, PhD, Tomomichi Kiyomatsu, MD, PhD, Keisuke Hata, MD, PhD, Hiroaki Nozawa, MD, PhD, Shinsuke Kazama, MD, PhD, Hironori Yamaguchi, MD, PhD, Soichiro Ishihara, MD, PhD, Eiji Sunami, MD, PhD, Joji Kitayama, MD, PhD, Kenichi Sugihara, MD, PhD, Toshiaki Watanabe, MD, PhD

Published in: Annals of Surgical Oncology | Special Issue 3/2015

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Abstract

Background

This study aimed to clarify differences in prognostic factors, metastatic features, and recurrence rates between histologic types in patients with stage 4 colorectal cancer (CRC) who had undergone curative resection.

Methods

The data from 1131 patients with stage 4 colorectal cancer from the databases of referral institutions were analyzed. The patients were divided into two groups according to histologic types as follows: patients with poorly differentiated adenocarcinoma, mucinous adenocarcinoma, or signet-ring cell carcinoma (Por/Muc/Sig) and patients with well-differentiated or moderately differentiated adenocarcinoma (Wel/Mod). Differences in clinicopathologic features, relapse-free survival (RFS) rates, and cancer-specific survival (CSS) rates between the groups were evaluated.

Results

Although RFS did not differ between the Por/Muc/Sig and Wel/Mod groups, CSS was significantly shorter in the Por/Muc/Sig group’s than in the Wel/Mod group, and survival after recurrence was significantly worse in the Por/Muc/Sig group than in theWel/Mod group. The incidence of peritoneal or local recurrence was significantly higher for the Por/Muc/Sig patients, whereas the resection recurrence rate was 16.4 %. Multivariate analysis suggested that histologic type was an independent prognostic factor for survival after recurrence.

Conclusions

The patients with Por/Muc/Sig CRC synchronous metastasis had significantly shorter survival times than the patients with other CRC histologies, even if the metastases were curatively resected.
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Metadata
Title
Prognostic Impact of Histologic Type in Curatively Resected Stage IV Colorectal Cancer: A Japanese Multicenter Retrospective Study
Authors
Junichi Shibata, MD
Kazushige Kawai, MD, PhD
Takeshi Nishikawa, MD, PhD
Toshiaki Tanaka, MD, PhD
Junichiro Tanaka, MD, PhD
Tomomichi Kiyomatsu, MD, PhD
Keisuke Hata, MD, PhD
Hiroaki Nozawa, MD, PhD
Shinsuke Kazama, MD, PhD
Hironori Yamaguchi, MD, PhD
Soichiro Ishihara, MD, PhD
Eiji Sunami, MD, PhD
Joji Kitayama, MD, PhD
Kenichi Sugihara, MD, PhD
Toshiaki Watanabe, MD, PhD
Publication date
01-12-2015
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-015-4846-z

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