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01-03-2009

Prognostic Factors of Pulmonary Metastasectomy for Colorectal Carcinomas

Authors: Fengshi Chen, Nobuharu Hanaoka, Kiyoshi Sato, Takuji Fujinaga, Makoto Sonobe, Tsuyoshi Shoji, Hiroaki Sakai, Ryo Miyahara, Toru Bando, Kenichi Okubo, Toshiki Hirata, Hiroshi Date

Published in: World Journal of Surgery | Issue 3/2009

Abstract

Background

Pulmonary metastasectomy for colorectal carcinoma is a well-accepted procedure; however, reports on indications and prognostic factors are inconsistent. This study was designed to clarify a role for resection of pulmonary metastases for such tumors and to define the patients who benefit from pulmonary metastasectomy.

Methods

Between 1990 and 2007, 84 patients with pulmonary metastases from colorectal carcinomas underwent curative pulmonary resection. All patients had obtained or had obtainable locoregional control of their primary tumors. Various perioperative variables were investigated retrospectively to confirm a role for metastasectomy and to analyze prognostic factors for overall survival and disease-free survival after metastasectomy.

Results

Overall survival rate after metastasectomy was 60.5% and 48.4% at 5 and 10 years, respectively. Disease-free survival rate was 34.4% and 30.6% at 5 and 10 years after pulmonary resection, respectively. On multivariate analysis, patients with unilateral pulmonary metastasis presented a significantly favorable overall survival (P = 0.045). In contrast, there was no significant prognostic factor for disease-free survival.

Conclusions

Current practice of pulmonary metastasectomy for colorectal carcinoma in our institution was well justified. Our study confirmed that unilateral pulmonary metastasis was significantly relevant to a better prognosis.

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Title: Prognostic Factors of Pulmonary Metastasectomy for Colorectal Carcinomas
Authors: Fengshi Chen
Nobuharu Hanaoka
Kiyoshi Sato
Takuji Fujinaga
Makoto Sonobe
Tsuyoshi Shoji
Hiroaki Sakai
Ryo Miyahara
Toru Bando
Kenichi Okubo
Toshiki Hirata
Hiroshi Date
Publication date: 01-03-2009
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 3/2009
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-008-9875-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognostic Factors of Pulmonary Metastasectomy for Colorectal Carcinomas

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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