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European Radiology
Published in: European Radiology 5/2017

01-05-2017 | Gastrointestinal

Prognostic aspects of dynamic contrast-enhanced magnetic resonance imaging in synchronous distant metastatic rectal cancer

Authors: Jing Yu, Qing Xu, Dong-Ya Huang, Jia-Cheng Song, Yan Li, Lu-Lu Xu, Hai-Bin Shi

Published in: European Radiology | Issue 5/2017

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Abstract

Objectives

To explore the correlations between DCE-MRI quantitative parameters and synchronous distant metastasis and the clinicopathological factors in rectal cancers.

Methods

Sixty-three patients with rectal cancer (synchronous distant metastasis, n = 31; non-metastasis, n = 32) were enrolled in this study. Student’s t test and ANOVA were used to compare DCE-MRI parameters (K trans , K ep and V e ). The receiver operating characteristic (ROC) analysis was used to find the reasonable threshold of DCE-MRI parameters to differentiate lesions with synchronous distant metastasis from those without metastasis.

Results

The K trans , K ep , and V e value were significantly higher in the lesions with distant metastasis than in the lesions without distant metastasis (0.536 ± 0.242 vs. 0.299 ± 0.118 min-1, p < 0.001; 1.598 ± 0.477 vs. 1.341 ± 0.390 min-1, p = 0.022; and 0.324 ± 0.173 vs. 0.249 ± 0.091, p = 0.034; respectively). The K trans showed the highest AUCs of 0.788 (p < 0.001), with sensitivity of 61.29 % and specificity of 87.5 %, respectively.

Conclusions

DCE-MRI parameters may represent a prognostic indicator for synchronous distant metastases in patients with rectal cancer.

Key Points

• The K trans , K ep and V e values correlated with synchronous distant metastasis.
• Higher K trans , K ep and V e values were noted among patients with metastasis.
• DCE-MRI parameters might represent a prognostic indicator for synchronous distant metastases.
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Metadata
Title
Prognostic aspects of dynamic contrast-enhanced magnetic resonance imaging in synchronous distant metastatic rectal cancer
Authors
Jing Yu
Qing Xu
Dong-Ya Huang
Jia-Cheng Song
Yan Li
Lu-Lu Xu
Hai-Bin Shi
Publication date
01-05-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 5/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4532-y

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