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Published in: Social Psychiatry and Psychiatric Epidemiology 12/2010

01-12-2010 | Original Paper

Profiles of disability among adults with bipolar spectrum disorders

Authors: Brian E. Perron, Amy S. B. Bohnert, Michael G. Vaughn, Mark S. Bauer, Amy M. Kilbourne

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 12/2010

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Abstract

Background

Heterogeneous groups of patients with a spectrum of service needs are commonplace in mental health settings. Although comprehensive assessments are available to measure variations in service needs, numerous challenges still exist when confronting this heterogeneity and many assessments used in clinic settings are lengthy and have not been demonstrated to be consistent over time.

Objective

The purpose of this study was to identify subgroups of persons with bipolar spectrum disorders, who have similar disability profiles, and to the extent to which the subgrouping is stable over time.

Methods

Participants were recruited from the Continuous Improvement for Veterans in Care–Mood Disorders. Eligible patients (N = 435) were those who received inpatient or outpatient treatment for bipolar disorder at a large urban VA mental health facility in Western Pennsylvania from July 2004 through July 2006. This was a naturalistic cohort study of patients with bipolar spectrum disorders. Baseline and 1-year follow-up data were collected using face-to-face interviews and recorded abstraction. The World Health Organization Disability Assessment Scale was the primary measure used to identify subgroups within this sample.

Results

Using a classification strategy called latent profile analysis, this study identified three unique subgroups that showed significant differences in various clinical measures at baseline and follow-up. The largest and most consistent subgroup differences were observed in the current bipolar symptomatology.

Conclusion

The classification of functional status in the present study can aid clinicians in the identification of bipolar patients, with specific impairment profiles, who may need additional intervention. Future research is needed to understand whether specific interventions targeted at these subgroups can improve the quality of care for this high-need and at-risk population.
Literature
1.
go back to reference Barsevick AM, Whitmer K, Nail LM, Beck SL, Dudley WN (2006) Symptom cluster research: conceptual, design, measurement, and analysis issues. J Pain Symptom Manage 31:85–95CrossRefPubMed Barsevick AM, Whitmer K, Nail LM, Beck SL, Dudley WN (2006) Symptom cluster research: conceptual, design, measurement, and analysis issues. J Pain Symptom Manage 31:85–95CrossRefPubMed
2.
go back to reference Bauer MS, McBride L (2003) Structured group psychotherapy for bipolar disorders. The Life Goals Program. Springer, NY Bauer MS, McBride L (2003) Structured group psychotherapy for bipolar disorders. The Life Goals Program. Springer, NY
3.
go back to reference Bauer MS, Crits-Christoph P, Ball WA, Dewees E, McAllister T, Alahi P, Cacciola J, Whybrow PC (1991) Independent assessment of manic and depressive symptoms by self-rating. Scale characteristics and implications for the study of mania. Arch Gen Psychiatry 48:807–812PubMed Bauer MS, Crits-Christoph P, Ball WA, Dewees E, McAllister T, Alahi P, Cacciola J, Whybrow PC (1991) Independent assessment of manic and depressive symptoms by self-rating. Scale characteristics and implications for the study of mania. Arch Gen Psychiatry 48:807–812PubMed
4.
go back to reference Bauer MS, Vojta C, Kinosian B, Altshuler L, Glick H (2000) The Internal State Scale: replication of its discriminating abilities in a multisite, public sector sample. Bipolar Disord 2:340–346CrossRefPubMed Bauer MS, Vojta C, Kinosian B, Altshuler L, Glick H (2000) The Internal State Scale: replication of its discriminating abilities in a multisite, public sector sample. Bipolar Disord 2:340–346CrossRefPubMed
5.
go back to reference Bauer MS, Kirk GF, Gavin C, Williford WO (2001) Determinants of functional outcome and healthcare costs in bipolar disorder: a high-intensity follow-up study. J Affect Disord 65:231–241CrossRefPubMed Bauer MS, Kirk GF, Gavin C, Williford WO (2001) Determinants of functional outcome and healthcare costs in bipolar disorder: a high-intensity follow-up study. J Affect Disord 65:231–241CrossRefPubMed
6.
7.
go back to reference Bauer M, Glenn T, Grof P, Rasgon NL, Marsh W, Sagduyu K, Alda M, Lewitzka U, Sasse J, Kozuch-Krolik E, Whybrow PC (2008) Frequency of subsyndromal symptoms and employment status in patients with bipolar disorder. Soc Psychiatry Psychiatr Epidemiol, in press Bauer M, Glenn T, Grof P, Rasgon NL, Marsh W, Sagduyu K, Alda M, Lewitzka U, Sasse J, Kozuch-Krolik E, Whybrow PC (2008) Frequency of subsyndromal symptoms and employment status in patients with bipolar disorder. Soc Psychiatry Psychiatr Epidemiol, in press
8.
go back to reference Blow FC, McCarthy JF, Valenstein M, Austin K, Gillon L (2000) Care for Veterans with Psychosis in the VHA, FY04: 6th Annual Nation Psychosis Registry Report. VA National Serious Mental Illness Treatment Research and Evaluation Center (SMITREC), Ann Arbor Blow FC, McCarthy JF, Valenstein M, Austin K, Gillon L (2000) Care for Veterans with Psychosis in the VHA, FY04: 6th Annual Nation Psychosis Registry Report. VA National Serious Mental Illness Treatment Research and Evaluation Center (SMITREC), Ann Arbor
9.
go back to reference Cameron IM, Crawford JR, Lawton K, Reid IC (2008) Psychometric comparison of PHQ-9 and HADS for measuring depression severity in primary care. Br J Gen Pract 58:32–36CrossRefPubMed Cameron IM, Crawford JR, Lawton K, Reid IC (2008) Psychometric comparison of PHQ-9 and HADS for measuring depression severity in primary care. Br J Gen Pract 58:32–36CrossRefPubMed
10.
go back to reference Cooke RG, Kruger S, Shugar G (1996) Comparative evaluation of two self-report Mania Rating Scales. Biol Psychiatry 40:279–283CrossRefPubMed Cooke RG, Kruger S, Shugar G (1996) Comparative evaluation of two self-report Mania Rating Scales. Biol Psychiatry 40:279–283CrossRefPubMed
11.
go back to reference Cooke RG, Robb JC, Young LT, Joffe RT (1996) Well-being and functioning in patients with bipolar disorder assessed using the MOS 20-ITEM short form (SF-20). J Affect Disord 39:93–97CrossRefPubMed Cooke RG, Robb JC, Young LT, Joffe RT (1996) Well-being and functioning in patients with bipolar disorder assessed using the MOS 20-ITEM short form (SF-20). J Affect Disord 39:93–97CrossRefPubMed
12.
go back to reference Coward-Bucher CE (2008) Toward a needs-based typology of homeless youth. J Adolesc Health 42:549–554CrossRefPubMed Coward-Bucher CE (2008) Toward a needs-based typology of homeless youth. J Adolesc Health 42:549–554CrossRefPubMed
13.
go back to reference Dickerson FB, Boronow JJ, Stallings CR, Origoni AE, Cole S, Yolken RH (2004) Association between cognitive functioning and employment status of persons with bipolar disorder. Psychiatr Serv 55:54–58CrossRefPubMed Dickerson FB, Boronow JJ, Stallings CR, Origoni AE, Cole S, Yolken RH (2004) Association between cognitive functioning and employment status of persons with bipolar disorder. Psychiatr Serv 55:54–58CrossRefPubMed
14.
go back to reference Dion GL, Tohen M, Anthony WA, Waternaux CS (1988) Symptoms and functioning of patients with bipolar disorder six months after hospitalization. Hosp Commun Psychiatry 39:652–657 Dion GL, Tohen M, Anthony WA, Waternaux CS (1988) Symptoms and functioning of patients with bipolar disorder six months after hospitalization. Hosp Commun Psychiatry 39:652–657
15.
go back to reference Fenn HH, Bauer MS, Altshuler L, Evans DR, Williford WO, Kilbourne AM, Beresford TP, Kirk G, Stedman M, Fiore L (2005) Medical comorbidity and health-related quality of life in bipolar disorder across the adult age span. J Affect Disord 86:47–60CrossRefPubMed Fenn HH, Bauer MS, Altshuler L, Evans DR, Williford WO, Kilbourne AM, Beresford TP, Kirk G, Stedman M, Fiore L (2005) Medical comorbidity and health-related quality of life in bipolar disorder across the adult age span. J Affect Disord 86:47–60CrossRefPubMed
16.
go back to reference Gitlin MJ, Swendsen J, Heller TL, Hammen C (1995) Relapse and impairment in bipolar disorder. Am J Psychiatry 152:1635–1640PubMed Gitlin MJ, Swendsen J, Heller TL, Hammen C (1995) Relapse and impairment in bipolar disorder. Am J Psychiatry 152:1635–1640PubMed
17.
go back to reference Gordon AJ, Maisto SA, McNeil M, Kraemer KL, Conigliaro RL, Kelley ME, Conigliaro J (2001) Three questions can detect hazardous drinkers. J Fam Pract 50:313–320PubMed Gordon AJ, Maisto SA, McNeil M, Kraemer KL, Conigliaro RL, Kelley ME, Conigliaro J (2001) Three questions can detect hazardous drinkers. J Fam Pract 50:313–320PubMed
18.
go back to reference Huang JA, Weng RH, Lai CS, Hu JS (2008) Exploring medical utilization patterns of emergency department users. J Formos Med Assoc 107:119–128CrossRefPubMed Huang JA, Weng RH, Lai CS, Hu JS (2008) Exploring medical utilization patterns of emergency department users. J Formos Med Assoc 107:119–128CrossRefPubMed
19.
go back to reference Judd LL, Akiskal HS (2003) The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases. J Affect Disord 73:123–131CrossRefPubMed Judd LL, Akiskal HS (2003) The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases. J Affect Disord 73:123–131CrossRefPubMed
20.
go back to reference Keck PE, McElroy SL, Strakowski SM, West SA, Sax KW, Hawkins JM, Bourne ML, Haggard P (2003) 12-Month outcome of patients with bipolar disorder following hospitalization for a manic or mixed episode. Focus 1:44–52 Keck PE, McElroy SL, Strakowski SM, West SA, Sax KW, Hawkins JM, Bourne ML, Haggard P (2003) 12-Month outcome of patients with bipolar disorder following hospitalization for a manic or mixed episode. Focus 1:44–52
21.
go back to reference Keller MB, Lavori PW, Coryell W, Andreasen NC, Endicott J, Clayton PJ, Klerman GL, Hirschfeld RM (1986) Differential outcome of pure manic, mixed/cycling, and pure depressive episodes in patients with bipolar illness. JAMA 255:3138–3142CrossRefPubMed Keller MB, Lavori PW, Coryell W, Andreasen NC, Endicott J, Clayton PJ, Klerman GL, Hirschfeld RM (1986) Differential outcome of pure manic, mixed/cycling, and pure depressive episodes in patients with bipolar illness. JAMA 255:3138–3142CrossRefPubMed
22.
go back to reference Kilbourne AM, Bauer MS, Pincus H, Williford WO, Kirk GF, Beresford T (2005) Clinical, psychosocial, and treatment differences in minority patients with bipolar disorder. Bipolar Disord 7:89–97CrossRefPubMed Kilbourne AM, Bauer MS, Pincus H, Williford WO, Kirk GF, Beresford T (2005) Clinical, psychosocial, and treatment differences in minority patients with bipolar disorder. Bipolar Disord 7:89–97CrossRefPubMed
23.
go back to reference Kilbourne AM, Brar JS, Drayer RA, Xu X, Post EP (2007) Cardiovascular disease and metabolic risk factors in male patients with schizophrenia, schizoaffective disorder, and bipolar disorder. Psychosomatics 48:412–417CrossRefPubMed Kilbourne AM, Brar JS, Drayer RA, Xu X, Post EP (2007) Cardiovascular disease and metabolic risk factors in male patients with schizophrenia, schizoaffective disorder, and bipolar disorder. Psychosomatics 48:412–417CrossRefPubMed
24.
go back to reference Kilbourne AM, Lasky E, Pincus HA, Good CB, Cooley S, Basavaraju A, Greenwald D, Fine MJ, Bauer MS (2008) The continuous improvement for veterans in care: Mood Disorders (civic-md) Study, a VA-academic partnership. Psychiatr Serv 59:483–485CrossRefPubMed Kilbourne AM, Lasky E, Pincus HA, Good CB, Cooley S, Basavaraju A, Greenwald D, Fine MJ, Bauer MS (2008) The continuous improvement for veterans in care: Mood Disorders (civic-md) Study, a VA-academic partnership. Psychiatr Serv 59:483–485CrossRefPubMed
25.
go back to reference Klinkman MS (1997) Competing demands in psychosocial care. A model for the identification and treatment of depressive disorders in primary care. Gen Hosp Psychiatry 19:98–111CrossRefPubMed Klinkman MS (1997) Competing demands in psychosocial care. A model for the identification and treatment of depressive disorders in primary care. Gen Hosp Psychiatry 19:98–111CrossRefPubMed
26.
go back to reference Klonsky ED, Olino TM (2008) Identifying clinically distinct subgroups of self-injurers among young adults: a latent class analysis. J Consult Clin Psychol 76:22–27CrossRefPubMed Klonsky ED, Olino TM (2008) Identifying clinically distinct subgroups of self-injurers among young adults: a latent class analysis. J Consult Clin Psychol 76:22–27CrossRefPubMed
27.
go back to reference Kroenke K, Spitzer RL, Williams JB (2001) The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 16:606–613CrossRefPubMed Kroenke K, Spitzer RL, Williams JB (2001) The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 16:606–613CrossRefPubMed
28.
go back to reference Leon AC, Shear MK, Portera L, Klerman GL (1992) Assessing impairment in patients with panic disorder: the Sheehan Disability Scale. Soc Psychiatry Psychiatr Epidemiol 27:78–82CrossRefPubMed Leon AC, Shear MK, Portera L, Klerman GL (1992) Assessing impairment in patients with panic disorder: the Sheehan Disability Scale. Soc Psychiatry Psychiatr Epidemiol 27:78–82CrossRefPubMed
29.
go back to reference Leon AC, Solomon DA, Mueller TI, Turvey CL, Endicott J, Keller MB (1999) The range of impaired functioning tool (LIFE-RIFT): a brief measure of functional impairment. Psychol Med 29:869–878CrossRefPubMed Leon AC, Solomon DA, Mueller TI, Turvey CL, Endicott J, Keller MB (1999) The range of impaired functioning tool (LIFE-RIFT): a brief measure of functional impairment. Psychol Med 29:869–878CrossRefPubMed
30.
31.
go back to reference Macias C, Jones DR, Hargreaves WA, Wang Q, Rodican CF, Barreira PJ, Gold PB (2008) When programs benefit some people more than others: tests of differential service effectiveness. Adm Policy Ment Health 1–12 Macias C, Jones DR, Hargreaves WA, Wang Q, Rodican CF, Barreira PJ, Gold PB (2008) When programs benefit some people more than others: tests of differential service effectiveness. Adm Policy Ment Health 1–12
32.
go back to reference McKibbin C, Patterson TL, Jeste DV (2004) Assessing disability in older patients with schizophrenia: results from the WHODAS-II. J Nerv Ment Dis 192:405–413CrossRefPubMed McKibbin C, Patterson TL, Jeste DV (2004) Assessing disability in older patients with schizophrenia: results from the WHODAS-II. J Nerv Ment Dis 192:405–413CrossRefPubMed
33.
go back to reference Perron BE, Ilgen MA, Hasche L, Howard MO (2008) Service needs of clients in outpatient substance-use disorder treatment: a latent class analysis. J Stud Alcohol Drugs 69:449–453PubMed Perron BE, Ilgen MA, Hasche L, Howard MO (2008) Service needs of clients in outpatient substance-use disorder treatment: a latent class analysis. J Stud Alcohol Drugs 69:449–453PubMed
34.
go back to reference Sevigny EL, Coontz PD (2008) Patterns of substance involvement and criminal behavior: a gender-based cluster analysis of Pennsylvania arrestees. Int J Offender Ther Comp Criminol 52:435–453CrossRefPubMed Sevigny EL, Coontz PD (2008) Patterns of substance involvement and criminal behavior: a gender-based cluster analysis of Pennsylvania arrestees. Int J Offender Ther Comp Criminol 52:435–453CrossRefPubMed
35.
go back to reference Shevlin M, Murphy J, Dorahy MJ, Adamson G (2007) The distribution of positive psychosis-like symptoms in the population: a latent class analysis of the National Comorbidity Survey. Schizophr Res 89:101–109CrossRefPubMed Shevlin M, Murphy J, Dorahy MJ, Adamson G (2007) The distribution of positive psychosis-like symptoms in the population: a latent class analysis of the National Comorbidity Survey. Schizophr Res 89:101–109CrossRefPubMed
36.
go back to reference Simon GE, Ludman EJ, Bauer MS, Unutzer J, Operskalski B (2006) Long-term effectiveness and cost of a systematic care program for bipolar disorder. Arch Gen Psychiatry 63:500–508CrossRefPubMed Simon GE, Ludman EJ, Bauer MS, Unutzer J, Operskalski B (2006) Long-term effectiveness and cost of a systematic care program for bipolar disorder. Arch Gen Psychiatry 63:500–508CrossRefPubMed
37.
go back to reference Spilsbury JC, Kahana S, Drotar D, Creeden R, Flannery DJ, Friedman S (2008) Profiles of behavioral problems in children who witness domestic violence. Violence Vict 23:3–17CrossRefPubMed Spilsbury JC, Kahana S, Drotar D, Creeden R, Flannery DJ, Friedman S (2008) Profiles of behavioral problems in children who witness domestic violence. Violence Vict 23:3–17CrossRefPubMed
38.
go back to reference Spitzer RL, Williams JB, Kroenke K, Linzer M, deGruy FV 3rd, Hahn SR, Brody D, Johnson JG (1994) Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study. JAMA 272:1749–1756CrossRefPubMed Spitzer RL, Williams JB, Kroenke K, Linzer M, deGruy FV 3rd, Hahn SR, Brody D, Johnson JG (1994) Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study. JAMA 272:1749–1756CrossRefPubMed
39.
go back to reference Watzke S, Galvao A, Brieger P (2008) Vocational rehabilitation for subjects with severe mental illnesses in Germany: a controlled study. Soc Psychiatry Psychiatr Epidemiol, in press Watzke S, Galvao A, Brieger P (2008) Vocational rehabilitation for subjects with severe mental illnesses in Germany: a controlled study. Soc Psychiatry Psychiatr Epidemiol, in press
Metadata
Title
Profiles of disability among adults with bipolar spectrum disorders
Authors
Brian E. Perron
Amy S. B. Bohnert
Michael G. Vaughn
Mark S. Bauer
Amy M. Kilbourne
Publication date
01-12-2010
Publisher
Springer-Verlag
Published in
Social Psychiatry and Psychiatric Epidemiology / Issue 12/2010
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI
https://doi.org/10.1007/s00127-009-0153-y

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