Published in:
01-10-2009 | Introduction
Probing the limits of regional tissue oxygenation measures
Authors:
Michael R Pinsky, Didier Payen
Published in:
Critical Care
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Special Issue 5/2009
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Excerpt
Assessment of tissue health is the Holy Grail in determining whether patients are in shock and when resuscitation efforts can be stopped because recovery has occurred. Tissue health, itself, results from the complex interaction between cardiac pump function, circulating blood volume and vasomotor tone, the number of capillary units perfused, and the ability of the tissue to use the delivered oxygen. Although the macro-circulation seems well evaluated both invasively and non-invasively using measures of blood pressure, cardiac output and mixed venous oxygen saturation, some studies suggest that resuscitation aiming only towards macrocirculatory parameters might be insufficient to improve tissue perfusion. …