Top

BMC Neurology

Published in:

Open Access 01-12-2012 | Case report

Probable levetiracetam-related serum alkaline phosphatase elevation

Authors: Nian Xiong, Lingling Hou, Na Lu, Asrah A Mohamed, Tao Wang, Yaling Huang

Published in: BMC Neurology | Issue 1/2012

Abstract

Background

Levetiracetam (LEV) is an antiepileptic drug with a favorable tolerability and safety profile with little or no effect on liver function.

Case presentation

Here, we reported an epileptic pediatric patient who developed a significant elevation in serum alkaline phosphatase level (ALP) during LEV monotherapy. Moreover, the serum ALP level was surprisingly decreased to normal after LEV discontinuation. The Naranjo Adverse Drug Reaction Probability Scale score was 6, indicating firstly LEV was a probable cause for the increased serum ALP.

Conclusions

Cautious usage and concerns of the LEV-associated potential ALP elevation should be considered when levetiracetam is prescribed to epilepsy patients, especially pediatric patients.

Available only for authorised users

Leppik IE: Issues in the treatment of epilepsy. Epilepsia. 2001, 42 (Suppl 4): 1-6.CrossRefPubMed

Wheless JW: Levetiracetam in the treatment of childhood epilepsy. Neuropsychiatr Dis Treat. 2007, 3 (4): 409-421.PubMedPubMedCentral

Krief P, Li K, Maytal J: Efficacy of levetiracetam in children with epilepsy younger than 2 years of age. J Child Neurol. 2008, 23 (5): 582-584. 10.1177/0883073807309781.CrossRefPubMed

Li S, Cao J, Xiao N, Cai F: Efficacy and safety of levetiracetam as an add-on therapy in children aged less than 4 years with refractory epilepsy. J Child Neurol. 2010, 25 (5): 609-613. 10.1177/0883073809342489.CrossRefPubMed

Perucca E: Designing clinical trials to assess antiepileptic drugs as monotherapy: difficulties and solutions. CNS Drugs. 2008, 22 (11): 917-938. 10.2165/00023210-200822110-00003.CrossRefPubMed

Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B: The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci U S A. 2004, 101 (26): 9861-9866. 10.1073/pnas.0308208101.CrossRefPubMedPubMedCentral

Rogawski MA: Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 2006, 69 (3): 273-294. 10.1016/j.eplepsyres.2006.02.004.CrossRefPubMedPubMedCentral

Briggs DE, French JA: Levetiracetam safety profiles and tolerability in epilepsy patients. Expert Opin Drug Saf. 2004, 3 (5): 415-424. 10.1517/14740338.3.5.415.CrossRefPubMed

Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ: A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981, 30 (2): 239-245. 10.1038/clpt.1981.154.CrossRefPubMed

10.

Narayanan S: Serum alkaline phosphatase isoenzymes as markers of liver disease. Ann Clin Lab Sci. 1991, 21 (1): 12-18.PubMed

11.

Dahlin MG, Wide K, Ohman I: Age and comedications influence levetiracetam pharmacokinetics in children. Pediatr Neurol. 2010, 43 (4): 231-235. 10.1016/j.pediatrneurol.2010.05.008.CrossRefPubMed

12.

Borusiak P, Langer T, Heruth M, Karenfort M, Bettendorf U, Jenke AC: Antiepileptic Drugs and Bone Metabolism in Children: Data from 128 Patients. J Child Neurol. 2012, 10.1177/0883073812443005.

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2377/12/97/prepub

Title: Probable levetiracetam-related serum alkaline phosphatase elevation
Authors: Nian Xiong
Lingling Hou
Na Lu
Asrah A Mohamed
Tao Wang
Yaling Huang
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2012
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/1471-2377-12-97

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Probable levetiracetam-related serum alkaline phosphatase elevation

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2012

Microalbuminuria indicates long-term vascular risk in patients after acute stroke undergoing in-patient rehabilitation

Intraocular pressure vs intracranial pressure in disease conditions: A prospective cohort study (Beijing iCOP study)

A prospective cohort study of stroke characteristics, care, and mortality in a hospital stroke registry in Vietnam

The effects of a home-based arm ergometry exercise programme on physical fitness, fatigue and activity in polio survivors: protocol for a randomised controlled trial

CMV-associated encephalitis and antineuronal autoantibodies - a case report

An outcome measure of functionality in patients with lumber spinal stenosis: a validation study of the Iranian version of Neurogenic Claudication Outcome Score (NCOS)