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Current Neurology and Neuroscience Reports
Published in: Current Neurology and Neuroscience Reports 11/2014

01-11-2014 | Genetics (V Bonifati, Section Editor)

Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies

Authors: Michel Goedert, Ben Falcon, Florence Clavaguera, Markus Tolnay

Published in: Current Neurology and Neuroscience Reports | Issue 11/2014

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Abstract

Neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are characterized by the abnormal aggregation of a small number of intracellular proteins, with tau and α-synuclein being the most commonly affected. Until recently, the events leading to aggregate formation were believed to be entirely cell-autonomous, with protein misfolding occurring independently in many cells. It is now believed that protein aggregates form in a small number of brain cells, from which they propagate intercellularly through templated recruitment, reminiscent of the mechanisms by which prions spread through the nervous system.
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Metadata
Title
Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies
Authors
Michel Goedert
Ben Falcon
Florence Clavaguera
Markus Tolnay
Publication date
01-11-2014
Publisher
Springer US
Published in
Current Neurology and Neuroscience Reports / Issue 11/2014
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-014-0495-z

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