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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 3/2008

01-03-2008

Primary Sclerosing Cholangitis: Role of Liver Transplantation

Author: William C. Chapman

Published in: Journal of Gastrointestinal Surgery | Issue 3/2008

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Excerpt

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by fibrosing inflammation of the intrahepatic and extrahepatic biliary tree. PSC typically presents in men younger than 50 years of age and is associated with coexisting inflammatory bowel disease (IBD, usually ulcerative colitis) in greater than 70% of patients. This association can present special problems, sometimes making decisions regarding timing of surgical treatment of the intestinal and liver disease challenging. …
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Portiz LS, Koltun WA. Surgical management of ulcerative colitis in the presence of primary sclerosing cholangitis. Dis Colon Rectum 2003;46:173–178.CrossRef
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Ho G, Seddon AJ, Therapondos G, Satsangi J, Hayes PC. The clinical course of ulcerative colitis after orthotopic liver transplantation for primary sclerosing cholangitis: further appraisal of immunosuppression post transplantation. Eur J Gastroenterol Hepatol 2005;17(12):1379–1385.PubMedCrossRef
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Burak K, Angulo P, Pasha TM, Egan K, Petz J, Lindor KD. Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis. Am J Gastroenterol 2004;99(3):523–526.PubMedCrossRef
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Metadata
Title
Primary Sclerosing Cholangitis: Role of Liver Transplantation
Author
William C. Chapman
Publication date
01-03-2008
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 3/2008
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-007-0343-4

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