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European Archives of Oto-Rhino-Laryngology

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01-11-2018 | Head & Neck

Primary parotid carcinoma: analysis of risk factors and validation of a prognostic index

Authors: Alberto Paderno, Michele Tomasoni, Davide Mattavelli, Simonetta Battocchio, Davide Lombardi, Piero Nicolai

Published in: European Archives of Oto-Rhino-Laryngology | Issue 11/2018

Abstract

Objectives

Primary cancer of the parotid gland (PG) is a rare disease characterized by a wide variety of histologies and subtypes. The aim of the study was to identify factors influencing survival and validate the prognostic scores (PS1 and PS2) by Vander Poorten et al.

Study design

Retrospective cohort study.

Methods

All patients with previously untreated PG epithelial malignancies who underwent surgery with curative intent from 2002 to 2015 at a single center were retrospectively reviewed.

Results

104 patients were included. Mean age was 60.2 years (range 14–88). Definitive pT staging was: 26 (25%) pT1, 19 (18.3%) pT2, 15 (14.4%) pT3, 41 (39.4%) pT4a, and 3 (2.9%) pT4b. Lateral neck nodal metastases were diagnosed in 27 (26%) patients. Five- and 10-year overall survival was 74.7% and 69.4%, respectively. Disease-specific survival at 5 and 10 years was 80.4% and 76.5%, respectively. Recurrence-free survival at 5 and 10 years was 66.9%. PS-1 and PS-2 scores correlated with prognosis. The most critical prognostic variables were grading, nodal metastases, perineural infiltration, lympho-vascular invasion, and skin infiltration.

Conclusions

Major risk factors in primary PG carcinomas can effectively identify high-risk patients. The prognostic score by Vander Poorten et al. is a highly reliable tool to predict the prognostic profile.

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Title: Primary parotid carcinoma: analysis of risk factors and validation of a prognostic index
Authors: Alberto Paderno
Michele Tomasoni
Davide Mattavelli
Simonetta Battocchio
Davide Lombardi
Piero Nicolai
Publication date: 01-11-2018
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 11/2018
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-018-5122-1

At a glance: The STEP trials

Springer Medicine

Primary parotid carcinoma: analysis of risk factors and validation of a prognostic index

Abstract

Objectives

Study design

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Study design

Methods

Results

Conclusions

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