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Indian Journal of Hematology and Blood Transfusion
Published in: Indian Journal of Hematology and Blood Transfusion 3/2021

01-07-2021 | Primary Immunodeficiency | Correspondence

A Rare Cause of Double Negative αβ T Cell Lymphocytosis

Authors: Harikrishnan Gangadharan, Ankita Singh, Komal Singh, Khaliqur Rahman, Amita Aggarwal

Published in: Indian Journal of Hematology and Blood Transfusion | Issue 3/2021

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Excerpt

Double-negative (DN) T lymphocytes (CD3 + CD4-CD8-T cell) usually comprise of <2.5% of total lymphocytes in peripheral blood. The most common cause of DN T cell lymphocytosis in children is autoimmune lymphoproliferative syndrome (ALPS) [1]. We describe the case of a child with non- ALPS related DN αβ T cell lymphocytosis. …
Appendix
Available only for authorised users
Literature
1.
2.
Oliveira JB, Bleesing JJ, Dianzani U et al (2010) Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop. Blood. 116(14):e35–e40CrossRef
3.
4.
Marin AV, Garcillán B, Jiménez-Reinoso A et al (2014) Human congenital T-cell receptor disorders. LymphoSign J 2(1):3–19CrossRef
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Dadi HK, Simon AJ, Roifman CM (2003) Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency. N Engl J Med 349(19):1821–1828CrossRef
Metadata
Title
A Rare Cause of Double Negative αβ T Cell Lymphocytosis
Authors
Harikrishnan Gangadharan
Ankita Singh
Komal Singh
Khaliqur Rahman
Amita Aggarwal
Publication date
01-07-2021
Publisher
Springer India
Published in
Indian Journal of Hematology and Blood Transfusion / Issue 3/2021
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-020-01381-x

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