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Published in: Journal of Medical Case Reports 1/2012

Open Access 01-12-2012 | Case report

Primary glioblastoma of the cerebellum in a 19-year-old woman: a case report

Authors: Moulay Rachid El El Maaqili, Adil Hossini, Nizar El Fatemi, Rachid Gana, Amar Saïdi, Mohammed Jiddane, Fouad Bellakhdar

Published in: Journal of Medical Case Reports | Issue 1/2012

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Abstract

Introduction

Cerebellar glioblastoma is an uncommon adult lesion. The pathogeny and prognosis of cerebellar glioblastoma are still incompletely elucidated.

Case presentation

We report the case of a 19-year-old Moroccan woman. A neurologic examination revealed the presence of cerebellar signs. A diagnosis of cerebellar glioblastoma is rarely made before surgery. An encephalic computer tomography scan and magnetic resonance imaging increased the accuracy of defining the nature of the lesion. Magnetic resonance imaging showed a heterogeneously enhancing mass in the vermis and the right cerebellar hemisphere. After surgery, glioblastoma was histologically confirmed. Post-operative radiotherapy followed. The outcome of our patient was favorable after one year of follow-up.

Conclusions

We report an unusual case of cerebellar gliobastoma. Cerebellar glioblastoma multiforme should be considered in the differential diagnosis of a cerebellar mass lesion.
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Literature
1.
go back to reference Grahovac G, Tomac D, Lambasa S: Cerebellar glioblastomas: pathophysiology, clinical presentation and management. Acta Neurochir. 2009, 151: 653-657. 10.1007/s00701-009-0286-5.CrossRefPubMed Grahovac G, Tomac D, Lambasa S: Cerebellar glioblastomas: pathophysiology, clinical presentation and management. Acta Neurochir. 2009, 151: 653-657. 10.1007/s00701-009-0286-5.CrossRefPubMed
2.
go back to reference Demir MK, Hakan T, Akinci O, Berkman Z: Primary cerebellar glioblastoma multiforme. Diagn Interv Radiol. 2005, 11: 83-86.PubMed Demir MK, Hakan T, Akinci O, Berkman Z: Primary cerebellar glioblastoma multiforme. Diagn Interv Radiol. 2005, 11: 83-86.PubMed
3.
go back to reference Mattos JP, Marenco HA, Campos JM, Faria AV, Queiroz LS, Borges G, de Oliveira E: Cerebellar glioblastoma multiforme in adult. Arq Neuropsiquiatr. 2006, 64: 132-135. 10.1590/S0004-282X2006000100028.CrossRefPubMed Mattos JP, Marenco HA, Campos JM, Faria AV, Queiroz LS, Borges G, de Oliveira E: Cerebellar glioblastoma multiforme in adult. Arq Neuropsiquiatr. 2006, 64: 132-135. 10.1590/S0004-282X2006000100028.CrossRefPubMed
4.
go back to reference Kuroiwa T, Numaguchi Y, Rothman MI, Zoarski GH, Morikawa M, Zagardo MT, Kristt DA: Posterior fossa glioblastoma multiforme: MR findings. AJNR Am J Neuroradiol. 1995, 16: 583-589.PubMed Kuroiwa T, Numaguchi Y, Rothman MI, Zoarski GH, Morikawa M, Zagardo MT, Kristt DA: Posterior fossa glioblastoma multiforme: MR findings. AJNR Am J Neuroradiol. 1995, 16: 583-589.PubMed
5.
go back to reference Stark AM, Nabavi A, Mehdorn HM, Blomer U: Glioblastoma multiforme-report of 267 cases treated at a single institution. Surg Neurol. 2005, 63: 162-169. 10.1016/j.surneu.2004.01.028.CrossRefPubMed Stark AM, Nabavi A, Mehdorn HM, Blomer U: Glioblastoma multiforme-report of 267 cases treated at a single institution. Surg Neurol. 2005, 63: 162-169. 10.1016/j.surneu.2004.01.028.CrossRefPubMed
6.
7.
go back to reference Kulkarni AV, Becker LE, Jay V, Armstrong DC, Drake JM: Primary cerebellar glioblastomas multiforme in children. Report of four cases. J Neurosurg. 1999, 90: 546-550. 10.3171/jns.1999.90.3.0546.CrossRefPubMed Kulkarni AV, Becker LE, Jay V, Armstrong DC, Drake JM: Primary cerebellar glioblastomas multiforme in children. Report of four cases. J Neurosurg. 1999, 90: 546-550. 10.3171/jns.1999.90.3.0546.CrossRefPubMed
8.
go back to reference Dohmann GJ, Dunsmore RH: Glioblastoma multiforme of the cerebellum. Surg Neurol. 1975, 3: 219-223. Dohmann GJ, Dunsmore RH: Glioblastoma multiforme of the cerebellum. Surg Neurol. 1975, 3: 219-223.
9.
go back to reference Benjamin R, Capparella J, Brown A: Classification of glioblastoma multiforme in adults by molecular genetics. Cancer J. 2003, 9: 82-90. 10.1097/00130404-200303000-00003.CrossRefPubMed Benjamin R, Capparella J, Brown A: Classification of glioblastoma multiforme in adults by molecular genetics. Cancer J. 2003, 9: 82-90. 10.1097/00130404-200303000-00003.CrossRefPubMed
10.
11.
go back to reference Maat-Schieman ML, Bots GT, Thomeer RT, Vielvoye GJ: Malignant astrocytoma following radiotherapy for craniopharyngioma. Br J Radiol. 1985, 58: 480-482. 10.1259/0007-1285-58-689-480.CrossRefPubMed Maat-Schieman ML, Bots GT, Thomeer RT, Vielvoye GJ: Malignant astrocytoma following radiotherapy for craniopharyngioma. Br J Radiol. 1985, 58: 480-482. 10.1259/0007-1285-58-689-480.CrossRefPubMed
12.
go back to reference Schmidbauer M, Budka H, Bruckner R, Vorkapic P: Glioblastoma developing at the site of a cerebellar medulloblastoma treated 6 years earlier. Case report. J Neurosurg. 1987, 67: 915-918. 10.3171/jns.1987.67.6.0915.CrossRefPubMed Schmidbauer M, Budka H, Bruckner R, Vorkapic P: Glioblastoma developing at the site of a cerebellar medulloblastoma treated 6 years earlier. Case report. J Neurosurg. 1987, 67: 915-918. 10.3171/jns.1987.67.6.0915.CrossRefPubMed
13.
go back to reference Law M, Cha S, Knopp EA, Johnson G, Arnett J, Litt AW: High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging. Radiology. 2002, 222: 715-721. 10.1148/radiol.2223010558.CrossRefPubMed Law M, Cha S, Knopp EA, Johnson G, Arnett J, Litt AW: High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging. Radiology. 2002, 222: 715-721. 10.1148/radiol.2223010558.CrossRefPubMed
14.
go back to reference Yung WK, Prados MD, Yaya-Tur R, Rosenfeld SS, Brada M, Friedman HS, Albright R, Olson J, Chang SM, O’Neill AM, Friedman AH, Bruner J, Yue N, Dugan M, Zaknoen S, Levin VA: Multicenter phase II trial of Temozolomide in patients with Anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumour Group. J Clin Oncol. 1999, 17: 2762-2771.PubMed Yung WK, Prados MD, Yaya-Tur R, Rosenfeld SS, Brada M, Friedman HS, Albright R, Olson J, Chang SM, O’Neill AM, Friedman AH, Bruner J, Yue N, Dugan M, Zaknoen S, Levin VA: Multicenter phase II trial of Temozolomide in patients with Anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumour Group. J Clin Oncol. 1999, 17: 2762-2771.PubMed
15.
go back to reference Stupp R, Mason WP, Van Den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO, European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups, National Cancer Institute of Canada Clinical Trials Group: Radiotherapy plus concomitant and adjuvant Temozolomide for glioblastoma. N Engl J Med. 2005, 352: 987-996. 10.1056/NEJMoa043330.CrossRefPubMed Stupp R, Mason WP, Van Den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO, European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups, National Cancer Institute of Canada Clinical Trials Group: Radiotherapy plus concomitant and adjuvant Temozolomide for glioblastoma. N Engl J Med. 2005, 352: 987-996. 10.1056/NEJMoa043330.CrossRefPubMed
Metadata
Title
Primary glioblastoma of the cerebellum in a 19-year-old woman: a case report
Authors
Moulay Rachid El El Maaqili
Adil Hossini
Nizar El Fatemi
Rachid Gana
Amar Saïdi
Mohammed Jiddane
Fouad Bellakhdar
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2012
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-6-329

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