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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2007

Open Access 01-12-2007 | Research

Primary colorectal small cell carcinoma: A clinicopathological and immunohistochemical study of 10 cases

Authors: Dina El Demellawy, Mahmoud A Khalifa, Nadia Ismiil, Shun Wong, Zeina Ghorab

Published in: Diagnostic Pathology | Issue 1/2007

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Abstract

Colorectal small cell carcinoma (SmCC) is a rare tumor with an aggressive course. The aim of this study is to summarize our experience with this tumor and to highlight its immunohistochemical profile. Ten cases of colorectal SmCC were identified in our files and a panel of immunostains was performed. Follow up was available for the average of 3 years, during which 7 patients died and 3 were alive with disease. All cases were positive for LMWK, CK 19 and pancytokeratin but were negative for TTF-1 and CA 125. EGFR was positive in 7 cases. TTF-1 negative staining may be valuable in differentiating it from its pulmonary counterpart. CDX2, mCEA, CD56, synaptophysin, NSE and chromogranin can help differentiate it from non-endocrine poorly differentiated adenocarcinoma. The expression of EGFR in a subset of patients has not been reported earlier and has to be evaluated in larger series to assess its role in the planning of targeted biologic therapy.
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Metadata
Title
Primary colorectal small cell carcinoma: A clinicopathological and immunohistochemical study of 10 cases
Authors
Dina El Demellawy
Mahmoud A Khalifa
Nadia Ismiil
Shun Wong
Zeina Ghorab
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2007
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-2-35

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