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Acta Neurologica Belgica
Published in: Acta Neurologica Belgica 3/2017

01-09-2017 | Letter to the Editor

Primary central nervous system lymphoma of T-cell origin: an unusual cause of spinal cord disease

Authors: Sophie Fastré, Frédéric London, Julie Lelotte, Alessandra Camboni, Anne Jeanjean

Published in: Acta Neurologica Belgica | Issue 3/2017

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Excerpt

Less than 1% of lymphomas are primary central nervous system lymphomas (PCNSL) [1]. Most of them are B-cell lineage and involve the supratentorial space, whereas T-cell origin and involvement of spinal cord are extremely rare [1]. Despite its rarity, primary spinal cord lymphoma (PSCL) of T-cell origin requires a meticulous diagnosis, because delayed treatment can shorten survival. However, there are no typical clinical features or radiological findings and it is always necessary to perform biopsy to obtain accurate pathological diagnosis so as to guide therapeutical decisions and avoid severe neurological sequelae. …
Literature
1.
Guzzetta M, Drexler S, Buonocore B, Donovan V (2015) Primary CNS T-cell lymphoma of the spinal cord: case report and literature review. Lab Med 46:159–163CrossRefPubMed
2.
Guzey FK, Hitay Y, Isler C, Tas A, Aktas O, Tufan A, Vatansever M, Akkalp AK (2015) Primary spinal intramedullary lymphoma: a case report and review of the literature. JSM Neurosurg Spine 3(1):1049
3.
Flanagan EP, O’Neill BP, Porter AB, Lanzino G, Haberman TM, Keegan BM (2011) Primary intramedullary spinal cord lymphoma. Neurology 77:784–791CrossRefPubMed
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Blay JY, Conroy T, Chevreau C, Thyss A, Quesnel N, Eghbali H, Bouabdallah R, Coiffier B, Wagner JP, Le Mevel A, Dramais-Marcel D, Baumelou E, Chauvin F, Biron P (1998) High-dose methotrexate for the treatment of primary cerebral lymphomas: analysis of survival and late neurologic toxicity in a retrospective series. J Clin Oncol 16:864–871CrossRefPubMed
Metadata
Title
Primary central nervous system lymphoma of T-cell origin: an unusual cause of spinal cord disease
Authors
Sophie Fastré
Frédéric London
Julie Lelotte
Alessandra Camboni
Anne Jeanjean
Publication date
01-09-2017
Publisher
Springer International Publishing
Published in
Acta Neurologica Belgica / Issue 3/2017
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-016-0726-y

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