Skip to main content
Top
Published in: Endocrine 3/2010

01-12-2010 | Case Report

Primary aldosteronism due to adrenocortical adenoma with concurrent ileum carcinoid tumor: case report

Authors: L. Zinnamosca, L. Petramala, D. Cotesta, C. Marinelli, S. Sciomer, G. Cavallaro, A. Ciardi, R. Massa, G. De Toma, S. Filetti, C. Letizia

Published in: Endocrine | Issue 3/2010

Login to get access

Abstract

Primary aldosteronism (PA) with synchronous carcinoid syndrome is extremely rare occurrence. In this article, we describe a case of PA due to adrenocortical adenoma (“aldosteronoma”) and concurrent malignant carcinoid tumor of ileum. The patient was treated with synchronous right adrenalectomy and resection of the ileum. This case is an example of concomitant presence of two types of tumors, effectively managed surgically. We report a case of a nonclassical form of multiple endocrine neoplasia type 1 (MEN 1) syndrome.
Literature
1.
go back to reference G.P. Rossi, G. Bernini, C. Caliumi, G. Desideri, B. Fabris, C. Ferri, C. Ganzaroli, G. Giacchetti, C. Letizia, M. Maccario, F. Mallamaci, M. Mannelli, M.J. Mattarello, A. Moretti, G. Palumbo, G. Parenti, E. Porteri, A. Semplicini, D. Rizzoni, E. Rossi, M. Boscaro, A.C. Pessina, F. Mantero, PAPY Study Investigators, A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients. J. Am. Coll. Cardiol. 48, 2293–2300 (2006)CrossRefPubMed G.P. Rossi, G. Bernini, C. Caliumi, G. Desideri, B. Fabris, C. Ferri, C. Ganzaroli, G. Giacchetti, C. Letizia, M. Maccario, F. Mallamaci, M. Mannelli, M.J. Mattarello, A. Moretti, G. Palumbo, G. Parenti, E. Porteri, A. Semplicini, D. Rizzoni, E. Rossi, M. Boscaro, A.C. Pessina, F. Mantero, PAPY Study Investigators, A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients. J. Am. Coll. Cardiol. 48, 2293–2300 (2006)CrossRefPubMed
2.
go back to reference L. Mosso, C. Carvajal, A. González, A. Barraza, F. Avila, J. Montero, A. Huete, A. Gederlini, C.E. Fardella, Primary aldosteronism and hypertensive disease. Hypertension 42, 161–165 (2003)CrossRefPubMed L. Mosso, C. Carvajal, A. González, A. Barraza, F. Avila, J. Montero, A. Huete, A. Gederlini, C.E. Fardella, Primary aldosteronism and hypertensive disease. Hypertension 42, 161–165 (2003)CrossRefPubMed
3.
go back to reference R.D. Gordon, M. Stowasser, T.J. Tunny, S.A. Klemm, J.C. Rutherford, High incidence of primary aldosteronism in 199 patients referred with hypertension. Clin. Exp. Pharmacol. Physiol. 21, 315–318 (1994)CrossRefPubMed R.D. Gordon, M. Stowasser, T.J. Tunny, S.A. Klemm, J.C. Rutherford, High incidence of primary aldosteronism in 199 patients referred with hypertension. Clin. Exp. Pharmacol. Physiol. 21, 315–318 (1994)CrossRefPubMed
4.
go back to reference K.C. Loh, E.S. Koay, M.C. Khaw, S.C. Emmanuel, W.F. Young Jr, Prevalence of primary aldosteronism among Asian hypertensive patients in Singapore. J. Clin. Endocrinol. Metab. 85, 2854–2859 (2000)CrossRefPubMed K.C. Loh, E.S. Koay, M.C. Khaw, S.C. Emmanuel, W.F. Young Jr, Prevalence of primary aldosteronism among Asian hypertensive patients in Singapore. J. Clin. Endocrinol. Metab. 85, 2854–2859 (2000)CrossRefPubMed
5.
go back to reference G.P. Rossi, A.C. Pessina, A.M. Heagerty, Primary aldosteronism: an update on screening, diagnosis and treatment. J. Hypertens. 26, 613–621 (2008)CrossRefPubMed G.P. Rossi, A.C. Pessina, A.M. Heagerty, Primary aldosteronism: an update on screening, diagnosis and treatment. J. Hypertens. 26, 613–621 (2008)CrossRefPubMed
6.
go back to reference H. Abe, K. Kubota, T. Noie, W. Kimura, M. Makuuchi, A rare combination consisting of primary hyperaldosteronism and glucagonoma. Am. J. Gastroenterol. 94, 1397–1401 (1999)CrossRefPubMed H. Abe, K. Kubota, T. Noie, W. Kimura, M. Makuuchi, A rare combination consisting of primary hyperaldosteronism and glucagonoma. Am. J. Gastroenterol. 94, 1397–1401 (1999)CrossRefPubMed
7.
go back to reference R.F. Berbarie, M. Emmett, N.A. Breslau, Quiz page. Secondary hypertension with contralateral pheochromocytoma and aldosteronoma. Am. J. Kidney Dis. 46(1), A51, e1-3 (2005) R.F. Berbarie, M. Emmett, N.A. Breslau, Quiz page. Secondary hypertension with contralateral pheochromocytoma and aldosteronoma. Am. J. Kidney Dis. 46(1), A51, e1-3 (2005)
8.
go back to reference M. Astegiano, F. Bresso, B. Demarchi, N. Sapone, D. Novero, G. Palestro, A. Resegotti, R. Pellicano, M. Rizzetto, Association between Crohn’s disease and Conn’s syndrome. A report of two cases. Panminerva Med. 47, 61–64 (2005)PubMed M. Astegiano, F. Bresso, B. Demarchi, N. Sapone, D. Novero, G. Palestro, A. Resegotti, R. Pellicano, M. Rizzetto, Association between Crohn’s disease and Conn’s syndrome. A report of two cases. Panminerva Med. 47, 61–64 (2005)PubMed
9.
go back to reference M. Honda, T. Tsukada, T. Horiuchi, R. Tanaka, K. Yamaguchi, T. Obara, H. Miyakawa, T. Yamaji, M. Ishibashi, Primary hyperparathyroidism associated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene. Intern. Med. 43, 310–314 (2004)CrossRefPubMed M. Honda, T. Tsukada, T. Horiuchi, R. Tanaka, K. Yamaguchi, T. Obara, H. Miyakawa, T. Yamaji, M. Ishibashi, Primary hyperparathyroidism associated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene. Intern. Med. 43, 310–314 (2004)CrossRefPubMed
10.
go back to reference A. Beckers, R. Abs, P.J. Willems, B. van der Auwera, K. Kovacs, M. Reznik, A. Stevenaert, Aldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia type 1 (MEN1): loss of heterozygosity for polymorphic chromosome 11 deoxyribonucleic acid markers, including the MEN1 locus. J. Clin. Endocrinol. Metab. 75, 564–570 (1992)CrossRefPubMed A. Beckers, R. Abs, P.J. Willems, B. van der Auwera, K. Kovacs, M. Reznik, A. Stevenaert, Aldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia type 1 (MEN1): loss of heterozygosity for polymorphic chromosome 11 deoxyribonucleic acid markers, including the MEN1 locus. J. Clin. Endocrinol. Metab. 75, 564–570 (1992)CrossRefPubMed
11.
12.
go back to reference G. Aggarwal, K. Obideen, M. Wehbi, Carcinoid tumors: what should increase our suspicion? Clevel. Clin. J. Med. 75, 849–855 (2008)CrossRef G. Aggarwal, K. Obideen, M. Wehbi, Carcinoid tumors: what should increase our suspicion? Clevel. Clin. J. Med. 75, 849–855 (2008)CrossRef
13.
go back to reference J.C. Yao, M. Hassan, A. Phan, C. Dagohoy, C. Leary, J.E. Mares, E.K. Abdalla, J.B. Fleming, J.N. Vauthey, A. Rashid, D.B. Evans, One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J. Clin. Oncol. 26, 3063–3072 (2008)CrossRefPubMed J.C. Yao, M. Hassan, A. Phan, C. Dagohoy, C. Leary, J.E. Mares, E.K. Abdalla, J.B. Fleming, J.N. Vauthey, A. Rashid, D.B. Evans, One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J. Clin. Oncol. 26, 3063–3072 (2008)CrossRefPubMed
14.
go back to reference I.M. Modlin, K. Oberg, D.C. Chung, R.T. Jensen, W.W. de Herder, R.V. Thakker, M. Caplin, G. Delle Fave, G.A. Kaltsas, E.P. Krenning, S.F. Moss, O. Nilsson, G. Rindi, R. Salazar, P. Ruszniewski, A. Sundin, Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol. 9, 61–72 (2008)CrossRefPubMed I.M. Modlin, K. Oberg, D.C. Chung, R.T. Jensen, W.W. de Herder, R.V. Thakker, M. Caplin, G. Delle Fave, G.A. Kaltsas, E.P. Krenning, S.F. Moss, O. Nilsson, G. Rindi, R. Salazar, P. Ruszniewski, A. Sundin, Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol. 9, 61–72 (2008)CrossRefPubMed
15.
go back to reference B. Eriksson, G. Klöppel, E. Krenning, H. Ahlman, U. Plöckinger, B. Wiedenmann, R. Arnold, C. Auernhammer, M. Körner, G. Rindi, S. Wildi, Frascati Consensus Conference participants. Consensus guidelines for the management of patients with digestive neuroendocrine tumors—well-differentiated jejunal-ileal tumor/carcinoma. Neuroendocrinology 87, 8–19 (2008)CrossRefPubMed B. Eriksson, G. Klöppel, E. Krenning, H. Ahlman, U. Plöckinger, B. Wiedenmann, R. Arnold, C. Auernhammer, M. Körner, G. Rindi, S. Wildi, Frascati Consensus Conference participants. Consensus guidelines for the management of patients with digestive neuroendocrine tumors—well-differentiated jejunal-ileal tumor/carcinoma. Neuroendocrinology 87, 8–19 (2008)CrossRefPubMed
16.
go back to reference J.D. Blumenfeld, J.E. Sealey, Y. Schlussel, E.D. Vaughan Jr., T.A. Sos, S.A. Atlas, F.B. Müller, R. Acevedo, S. Ulick, J.H. Laragh, Diagnosis and treatment of primary hyperaldosteronism. Ann. Intern. Med. 121, 877–885 (1994)PubMed J.D. Blumenfeld, J.E. Sealey, Y. Schlussel, E.D. Vaughan Jr., T.A. Sos, S.A. Atlas, F.B. Müller, R. Acevedo, S. Ulick, J.H. Laragh, Diagnosis and treatment of primary hyperaldosteronism. Ann. Intern. Med. 121, 877–885 (1994)PubMed
18.
go back to reference J.K. Ramage, A.H. Davies, J. Ardill, N. Bax, M. Caplin, A. Grossman, R. Hawkins, A.M. McNicol, N. Reed, R. Sutton, R. Thakker, S. Aylwin, D. Breen, K. Britton, K. Buchanan, P. Corrie, A. Gillams, V. Lewington, D. McCance, K. Meeran, A. Watkinson, UKNETwork for Neuroendocrine Tumours. Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours. Gut. 54 Suppl 4, iv1-16 (2005) J.K. Ramage, A.H. Davies, J. Ardill, N. Bax, M. Caplin, A. Grossman, R. Hawkins, A.M. McNicol, N. Reed, R. Sutton, R. Thakker, S. Aylwin, D. Breen, K. Britton, K. Buchanan, P. Corrie, A. Gillams, V. Lewington, D. McCance, K. Meeran, A. Watkinson, UKNETwork for Neuroendocrine Tumours. Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours. Gut. 54 Suppl 4, iv1-16 (2005)
19.
go back to reference W.W. de Herder, Tumours of the midgut (jejunum, ileum and ascending colon, including carcinoid syndrome). Best Pract. Res. Clin. Gastroenterol. 19, 705–715 (2005)CrossRefPubMed W.W. de Herder, Tumours of the midgut (jejunum, ileum and ascending colon, including carcinoid syndrome). Best Pract. Res. Clin. Gastroenterol. 19, 705–715 (2005)CrossRefPubMed
20.
21.
go back to reference M.A. Maggard, J.B. O’Connell, C.Y. Ko, Updated population-based review of carcinoid tumors. Ann. Surg. 240, 117–122 (2004)CrossRefPubMed M.A. Maggard, J.B. O’Connell, C.Y. Ko, Updated population-based review of carcinoid tumors. Ann. Surg. 240, 117–122 (2004)CrossRefPubMed
22.
go back to reference I.M. Modlin, M. Kidd, I. Latich, M.N. Zikusoka, M.D. Shapiro, Current status of gastrointestinal carcinoids. Gastroenterology 128, 1717–1751 (2005)CrossRefPubMed I.M. Modlin, M. Kidd, I. Latich, M.N. Zikusoka, M.D. Shapiro, Current status of gastrointestinal carcinoids. Gastroenterology 128, 1717–1751 (2005)CrossRefPubMed
23.
go back to reference A.N. van der Horst-Schrivers, A.N. Wymenga, T.P. Links, P.H. Willemse, I.P. Kema, E.G. de Vries, Complications of midgut carcinoid tumors and carcinoid syndrome. Neuroendocrinology 80, 28–32 (2004)CrossRefPubMed A.N. van der Horst-Schrivers, A.N. Wymenga, T.P. Links, P.H. Willemse, I.P. Kema, E.G. de Vries, Complications of midgut carcinoid tumors and carcinoid syndrome. Neuroendocrinology 80, 28–32 (2004)CrossRefPubMed
25.
go back to reference F. Assadi, Diagnosis of hypokalemia: a problem-solving approach to clinical cases. Iran. J. Kidney Dis. 2, 115–122 (2008)PubMed F. Assadi, Diagnosis of hypokalemia: a problem-solving approach to clinical cases. Iran. J. Kidney Dis. 2, 115–122 (2008)PubMed
26.
go back to reference G.W. Herd, A case of primary hyperparathyroidism, primary hyperaldosteronism and Cushing’s disease. Acta Endocrinol. (Copenh) 107, 371–374 (1984) G.W. Herd, A case of primary hyperparathyroidism, primary hyperaldosteronism and Cushing’s disease. Acta Endocrinol. (Copenh) 107, 371–374 (1984)
27.
go back to reference A. Fertig, M. Webley, J.A. Lynn, Primary hyperparathyroidism in a patient with Conn’s syndrome. Postgrad. Med. J. 56, 45–47 (1980)CrossRefPubMed A. Fertig, M. Webley, J.A. Lynn, Primary hyperparathyroidism in a patient with Conn’s syndrome. Postgrad. Med. J. 56, 45–47 (1980)CrossRefPubMed
28.
go back to reference D.E. Hellman, M. Kartchner, N. Komar, D. Mayes, M. Pitt, Hyperaldosteronism, hyperparathyroidism, medullary sponge kidneys, and hypertension. JAMA 244, 1351–1353 (1980)CrossRefPubMed D.E. Hellman, M. Kartchner, N. Komar, D. Mayes, M. Pitt, Hyperaldosteronism, hyperparathyroidism, medullary sponge kidneys, and hypertension. JAMA 244, 1351–1353 (1980)CrossRefPubMed
29.
go back to reference R.F. Gagel, S.J. Marx, Multiple endocrine neoplasia, in Williams Textbook of Endocrinology 11th edn, ed. by P.R. Larsen, M. Kroenenberg, S. Helmed, K. Polonsky (WB Saunders & Company, Orlando, 2007) (Section X, Chap 40) R.F. Gagel, S.J. Marx, Multiple endocrine neoplasia, in Williams Textbook of Endocrinology 11th edn, ed. by P.R. Larsen, M. Kroenenberg, S. Helmed, K. Polonsky (WB Saunders & Company, Orlando, 2007) (Section X, Chap 40)
30.
go back to reference A. Falchetti, F. Marini, E. Luzi, F. Tonelli, M.L. Brandi, Multiple endocrine neoplasms. Best Pract. Res. Clin. Rheumatol. 22, 149–163 (2008)CrossRefPubMed A. Falchetti, F. Marini, E. Luzi, F. Tonelli, M.L. Brandi, Multiple endocrine neoplasms. Best Pract. Res. Clin. Rheumatol. 22, 149–163 (2008)CrossRefPubMed
31.
go back to reference S.C. Chandrasekharappa, S.C. Guru, P. Manickam, S.E. Olufemi, F.S. Collins, M.R. Emmert-Buck, L.V. Debelenko, Z. Zhuang, I.A. Lubensky, L.A. Liotta, J.S. Crabtree, Y. Wang, B.A. Roe, J. Weisemann, M.S. Boguski, S.K. Agarwal, M.B. Kester, Y.S. Kim, C. Heppner, Q. Dong, A.M. Spiegel, A.L. Burns, S.J. Marx, Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276, 404–407 (1997)CrossRefPubMed S.C. Chandrasekharappa, S.C. Guru, P. Manickam, S.E. Olufemi, F.S. Collins, M.R. Emmert-Buck, L.V. Debelenko, Z. Zhuang, I.A. Lubensky, L.A. Liotta, J.S. Crabtree, Y. Wang, B.A. Roe, J. Weisemann, M.S. Boguski, S.K. Agarwal, M.B. Kester, Y.S. Kim, C. Heppner, Q. Dong, A.M. Spiegel, A.L. Burns, S.J. Marx, Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276, 404–407 (1997)CrossRefPubMed
32.
go back to reference S.S. Guo, M.P. Sawicki, Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia type-1. Mol. Endocrinol. 15, 1653–1664 (2001)CrossRefPubMed S.S. Guo, M.P. Sawicki, Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia type-1. Mol. Endocrinol. 15, 1653–1664 (2001)CrossRefPubMed
Metadata
Title
Primary aldosteronism due to adrenocortical adenoma with concurrent ileum carcinoid tumor: case report
Authors
L. Zinnamosca
L. Petramala
D. Cotesta
C. Marinelli
S. Sciomer
G. Cavallaro
A. Ciardi
R. Massa
G. De Toma
S. Filetti
C. Letizia
Publication date
01-12-2010
Publisher
Springer US
Published in
Endocrine / Issue 3/2010
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-010-9394-5

Other articles of this Issue 3/2010

Endocrine 3/2010 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine