Top

Published in:

01-07-2010 | Short Report

Primary adrenal failure due to viral infection in an infant

Authors: Leyla Akın, Selim Kurtoglu, Mustafa Kendirci, Mustafa Ali Akın, Fatih Kardas

Published in: European Journal of Pediatrics | Issue 7/2010

Abstract

Acquired primary adrenal insufficiency is a rare disorder in childhood. The most common cause is autoimmune adrenalitis, especially as a part of polyendocrinopathy syndromes. Impaired adrenal function is seen in patients infected with HIV. In adult patients with AIDS, cytomegalovirus (CMV)-associated adrenal insufficiency is a well-known condition, whereas CMV infection as a causing adrenal insufficiency in children is very rare. Here, we report an infant with transient adrenal insufficiency associated with CMV infection but without HIV. She was treated successfully with steroid replacement and ganciclovir. Early diagnosis and treatment is lifesaving in these patients.

Bissinger AL, Sinzger C, Kaiserling E et al (2002) Human cytomegalovirus as a direct pathogen: correlation of multiorgan involvement and cell distribution with clinical and pathological findings in a case of congenital inclusion disease. J Med Virol 67:200–206CrossRefPubMed

Dinleyici EC, Dogruel N, Dinleyici M et al (2009) Adrenal insufficiency associated with cytomegalovirus infection in two infants. Int J Infect Dis 13:181–184CrossRef

Drew WL (1988) Cytomegalovirus infection in patients with AIDS. J Infect Dis 158:449–456PubMed

Hertel NT, Jacobsen BB, Pedersen FK et al (1987) Adrenocortical insufficiency associated with Epstein–Barr virus infection in a patient with the Wiskott–Aldrich syndrome. Eur J Pediatr 146:603–604CrossRefPubMed

Hoshino Y, Nagata Y, Gatanaga H et al (1997) Cytomegalovirus (CMV) retinitis and CMV antigenemia as a clue to impaired adrenocortical function in patients with AIDS. AIDS 11:1719–1724CrossRefPubMed

Perry R, Kecha O, Paquette J et al (2005) Primary adrenal insufficiency in children: twenty years experience at the Sainte-Justine Hospital, Montreal. J Clin Endocrinol Metab 90:3243–3250CrossRefPubMed

Pulakhandam U, Dincsoy HP (1990) Cytomegalovirus adrenalitis and adrenal insufficiency in AIDS. Am J Clin Pathol 93:651–656PubMed

Razzaq F, Dunbar EM, Bonington A (2002) The development of cytomegalovirus induced adrenal failure in a patient with AIDS while receiving corticosteroid therapy. HIV Med 3:212–214CrossRefPubMed

Root AW, Shulman DI (2004) In: Pescovitz OH, Eugster EA (eds) Pediatric endocrinology. Lippincott Williams & Wilkins, Philadelphia, pp 565–600

10.

Sanhes L, Michez E, Essig M et al (1995) Successful treatment of CMV-induced adrenal insufficiency by ganciclovir in a patient with the acquired immune deficiency syndrome. Nephron Dial Transplant 10:704–705

11.

Shulman DI, Palmert MR, Kemp SF, Lawson Wilkins Drug and Therapeutics Committee (2007) Adrenal insufficiency: still a cause of morbidity and death in childhood. Pediatrics 119:484–494CrossRef

12.

Ten S, New M, Maclaren N (2001) Clinical review 130: Addison's disease 2001. J Clin Endocrinol Metab 86:2909–2922CrossRefPubMed

13.

White PC, Speiser PW (2000) Congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Endocr Rev 21:245–291CrossRefPubMed

Title: Primary adrenal failure due to viral infection in an infant
Authors: Leyla Akın
Selim Kurtoglu
Mustafa Kendirci
Mustafa Ali Akın
Fatih Kardas
Publication date: 01-07-2010
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 7/2010
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-009-1103-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Primary adrenal failure due to viral infection in an infant

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 7/2010

Purpura fulminans in a newborn infant with galactosemia

The epidemiology of childhood poisonings in Cyprus

Steroid 11-beta hydroxylase deficiency caused by compound heterozygosity for a novel mutation in intron 7 (IVS 7 DS+4A to G) in one CYP11B1 allele and R448H in exon 8 in the other

House dust mite-related allergic diseases: role of skin prick test, atopy patch test, and RAST in the diagnosis of different manifestations of allergy

Outbreak of Candida parapsilosis in a neonatal intensive care unit: a health care workers source

Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation showing DiGeorge sequence including hypoparathyroidism