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Drugs
Published in: Drugs 3/2016

01-03-2016 | Review Article

Prevention and Treatment of Venous Thromboembolism in Patients with Cancer: Focus on Drug Therapy

Authors: Nick van Es, Suzanne M. Bleker, Ineke T. Wilts, Ettore Porreca, Marcello Di Nisio

Published in: Drugs | Issue 3/2016

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Abstract

Venous thromboembolism (VTE) is a frequent complication in patients with cancer and is associated with significant morbidity and mortality. The use of anticoagulants for the prevention and treatment of VTE in this population is challenging given the high risk of both recurrent VTE and bleeding complications. Thromboprophylaxis with subcutaneous low-molecular-weight heparin (LMWH) is recommended in cancer patients hospitalized for an acute medical illness and in those undergoing major surgery. In ambulatory cancer patients with or without central venous catheters, routine thromboprophylaxis is not recommended because of the relatively low benefit-to-risk ratio. To identify cancer outpatients at very high risk of VTE who may benefit from thromboprophylaxis, VTE risk stratification tools based on tumour type, clinical parameters, or coagulation biomarkers have been proposed, but their clinical utility needs validation. The mainstay of treatment for cancer-associated VTE is LMWH for at least 6 months or longer in case of active disease. The same initial and long-term treatment for incidental VTE as for symptomatic VTE can be suggested while awaiting additional studies in this area.
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Metadata
Title
Prevention and Treatment of Venous Thromboembolism in Patients with Cancer: Focus on Drug Therapy
Authors
Nick van Es
Suzanne M. Bleker
Ineke T. Wilts
Ettore Porreca
Marcello Di Nisio
Publication date
01-03-2016
Publisher
Springer International Publishing
Published in
Drugs / Issue 3/2016
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-015-0526-3

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