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01-07-2018 | Review

Prevalence of psychopathology in bipolar high-risk offspring and siblings: a meta-analysis

Authors: Phoebe Lau, David J. Hawes, Caroline Hunt, Andrew Frankland, Gloria Roberts, Philip B. Mitchell

Published in: European Child & Adolescent Psychiatry | Issue 7/2018

Abstract

This meta-analysis aimed to update existing data on the comparison of prevalence rates of psychopathology primarily among offspring with at least one parent with bipolar disorder (BD) and offspring of parents without psychiatric illness. Seventeen studies were derived from a systematic search of PsychInfo, Medline, Scopus and Embase. Inclusion criteria were use of a control offspring group, standardized diagnostic procedures and reporting of clear frequency data. Risk of psychopathology was estimated by aggregating frequency data from selected studies. Compared to control offspring, high-risk BD offspring are nine times more likely to have a bipolar-type disorder, almost two and a half times more likely to develop a non-BD affective disorder and over two times more likely to develop at least one anxiety disorder. High-risk offspring also showed a significant increased risk of other non-mood psychopathology such as attention deficit hyperactivity disorder (ADHD), any type of behavioral disorder and substance use disorder (SUDs). Risk of developing a broad range of affective and non-affective psychopathology is significantly higher in high-risk BD offspring. Identifying clinical presentations of this genetically high-risk cohort is important in establishing appropriate preventative treatment.

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Title: Prevalence of psychopathology in bipolar high-risk offspring and siblings: a meta-analysis
Authors: Phoebe Lau
David J. Hawes
Caroline Hunt
Andrew Frankland
Gloria Roberts
Philip B. Mitchell
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: European Child & Adolescent Psychiatry / Issue 7/2018
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-017-1050-7

At a glance: The STEP trials

Springer Medicine

Prevalence of psychopathology in bipolar high-risk offspring and siblings: a meta-analysis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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