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01-08-2014 | Short Communication

Prevalence of human Herpesviridae in cerebrospinal fluid of patients with multiple sclerosis and noninfectious neurological disease in the Netherlands

Authors: Gijsbert P. van Nierop, Rogier Q. Hintzen, Georges M. G. M. Verjans

Published in: Journal of NeuroVirology | Issue 4/2014

Abstract

Prevalence of eight human herpesviruses (HHV1–8) was determined by real-time PCR in cell-rich cerebrospinal fluid (CSF) samples, obtained early after disease symptoms, of Dutch patients with multiple sclerosis (MS) and other noninfectious central nervous system diseases (NIND). Whereas HHV1–8 DNA was undetectable in CSF samples of MS patients, HHV6 DNA was detected in a plexus neuritis case and HHV7 DNA in an ependymoma and a Behçets’ disease patient. However, intrathecal HHV infection was not detected. Data indicate that HHV1–8 are rarely detected in CSF of Dutch NIND patients and do not support the role of intrathecal HHV infection early after onset of disease symptoms in MS.

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Title: Prevalence of human Herpesviridae in cerebrospinal fluid of patients with multiple sclerosis and noninfectious neurological disease in the Netherlands
Authors: Gijsbert P. van Nierop
Rogier Q. Hintzen
Georges M. G. M. Verjans
Publication date: 01-08-2014
Publisher: Springer US
Published in: Journal of NeuroVirology / Issue 4/2014
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-014-0248-4

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Prevalence of human Herpesviridae in cerebrospinal fluid of patients with multiple sclerosis and noninfectious neurological disease in the Netherlands

Abstract

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Abstract

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