Top

Journal of Diabetes & Metabolic Disorders

Published in:

Open Access 01-12-2014 | Review article

Prevalence of diabetic peripheral neuropathy in Iran: a systematic review and meta-analysis

Authors: Sahar Sobhani, Hamid Asayesh, Farshad Sharifi, Shirin Djalalinia, Hamid Reza Baradaran, Seyed Masoud Arzaghi, Morteza Mansourian, Aziz Rezapoor, Hossein Ansari, Mohammad Parvaresh Masoud, Mostafa Qorbani

Published in: Journal of Diabetes & Metabolic Disorders | Issue 1/2014

Abstract

Diabetic peripheral neuropathy (DPN) is an important microvascular complication of diabetes mellitus (DM). It is a major contributor to foot ulceration and lower limb amputation in persons with DM and have also a significant negative effect on patient's quality of life. This meta-analysis reviews prevalence of DPN among patients with type 1 and 2 DM in Iran. Using PubMed and NLM Gateway (for MEDLINE), Institute of Scientific Information (ISI), and SCOPUS as the main international electronic data sources, and Iranmedex, Irandoc, and Scientific Information Database (SID), as the main domestic databases with systematic search capability, we systematically searched surveys, papers, and reports on the prevalence of DPN (between January 1991 to February 2013). Heterogeneity of reported prevalence's between studies was assessed by the Chi-square-based Q test and due to heterogeneity; overall prevalence of DPN was estimated using random-effect meta-analysis model. We found 304 records; from them a total of 21 studies comprising 5540 diabetic patients were included. The prevalence of diabetic neuropathy (reported) from 16% to 87%. In overall the prevalence of DPN estimated 53% (95% CI: 41-65) by using random-effect. This study show that the prevalence of DPN seems very high among the population with diabetes in Iran and more than half of the patients with DM has any type of diabetic neuropathy.

Available only for authorised users

Vinik AI, Mehrabyan A: Diabetic neuropathies. Med Clin North Am 2004, 88: 947–999. 10.1016/j.mcna.2004.04.009CrossRefPubMed

Harris M, Eastman R, Cowie C: Symptoms of sensory neuropathy in adults with NIDDM in the US population. Diabetes Care 1993, 16: 1446–1452. 10.2337/diacare.16.11.1446CrossRefPubMed

Boulton AJ, Malik RA, Arezzo JC: Diabetic somatic neuropathies. Diabetes Care 2004, 27: 1458–1486. 10.2337/diacare.27.6.1458CrossRefPubMed

Galer BS, Gianas A, Jensen MP: Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life. Diabetes Res Clin Pract 2000, 47: 123–128. 10.1016/S0168-8227(99)00112-6CrossRefPubMed

Gordois A, Scuffham P, Shearer A, Oglesby A, Tobian JA: The health care costs of diabetic peripheral neuropathy in the US. Diabetes Care 2003, 26: 1790–1795. 10.2337/diacare.26.6.1790CrossRefPubMed

Veves A, Backonja M, Malik RA: Painful diabetic neuropathy: epidemiology, natural history, early diagnosis, and treatment options. Pain Med 2008, 9: 660–674. 10.1111/j.1526-4637.2007.00347.xCrossRefPubMed

Barrett AM, Lucero MA, Le T, Robinson RL, Dworkin RH, Chappell AS: Epidemiology, public health burden, and treatment of diabetic peripheral neuropathic pain: a review. Pain Med 2007, 8: S50-S62. 10.1111/j.1526-4637.2006.00179.xCrossRefPubMed

Mcbride T, Coburn A, Mackinney C, Mueller K, Slifkin R, Wakefield M: Bridging health research and policy: effective dissemination strategies. J Public Health Manag Pract 2008, 14: 150–154. 10.1097/01.PHH.0000311893.80701.7aCrossRefPubMed

Brownson RC, Jones E: Bridging the gap: translating research into policy and practice. Prev Med 2009, 49: 313–315. 10.1016/j.ypmed.2009.06.008CrossRefPubMed

10.

Kiani J, Moghimbeigi A, Azizkhani H, Kosarifard S: The prevalence and associated risk factors of peripheral diabetic neuropathy in Hamedan, Iran. Arch Iran Med 2013, 16: 17–19.PubMed

11.

Tesfaye S, Boulton AJM, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P: Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care 2010, 33: 2285–2293. 10.2337/dc10-1303CrossRefPubMedPubMedCentral

12.

Hasani N, Khosrawi S, Hashemipour M, Haghighatiyan M, Javdan Z, Taheri MH, Kelishadi R, Amini M, Barekatein R: Prevalence and related risk-factors of peripheral neuropathy in children with insulin-dependent diabetes mellitus. J Res Med Sci 2013, 18: 132–136.PubMedPubMedCentral

13.

Boostani R, Afkhamizade M, Shahri B, Ahmadi S: Evaluation of the frequency of polyneuropathy based upon the clinical and paraclinical findings in diabetic patients. Med J Mashhad Uni Med Sci 2012, 55: 81–87.

14.

Talaee R, Doroudgar A, Muosavi Seyyed G, Abdevali N: Detection of sensory neuropathy in diabetic patients using 5.07/10g monofilament. J Derma Cos 2011, 2: 158–165.

15.

Tabatabaei Molazi A, MohajeriTehrani MR, Madani SP, Heshmat R, Larijani B: The prevalence diabetic peripheral neuropathy and related factors. Iran J Diabetes Lipid Disord 2011, 40: 55–62.

16.

Cheraghi Z, Amori N, DostiIrani A, Bitaraf S: The investigation of type 2 diabetes complications among patients of Shadegan health center diabetes clinic, in 2008. Knowledge Health J 2010, 5: 154–155.

17.

Afkhami-Ardekani M, Zahmatkash M: Prevalence of Type 2 diabetes complications and their contributing factors in Yazd Province. Iran J Diabetes Obes 2009, 1: 36–44.

18.

SadeghieAharai S, Arshi S, Iranparvar M, Amani F, Siahpoosh H: The Effect of Complications of Type II Diabetes on Patients' Quality of Life. Med J Ardabil Univ Med Sci 2009, 8: 394–402.

19.

Ghorbani A, Rezvanian H, Kazemi A, Saberi A: Determination of diabetic- polyneuropathy prevalence through clinical examination and electrodiognostic findings. J Birjand Med Sci Univ 2008, 14: 36–41.

20.

Abbasian M, Delvarianzadeh M: Evaluation of diabetes complications among the diabetic patients visiting the Shahroud diabetic's clinic. Danesh Tandorosti 2008, 4: 17–21.

21.

Baghiani Moghadam MH, Afkhami Ardakani M, Mazloumi SS, Saaidizadeh M: quality of life in diabetes type II patients in Yazd. J Shahid Sadoughi Uni Med Sci Health Serv 2007, 14: 49–54.

22.

Ghavami H, Ahmadi F, Mehin S, Meamarian R, Entezami H: Assessment of the relation between diabetic neuropathy & HbA1C concentration. J Iran Univ Medl Sci 2007, 53: 141–147.

23.

Khazai MH, Khazai B, Zargaran Z, Moosavi Z, Khadivi ZF: Diabetic complications and risk factors in recently diagnosed type II diabetes: a case-control study. ARYA J 2006, 2: 79–83.

24.

Janghorbani M, Rezvanian H, Kachooei A, Ghorbani A, Chitsaz A, Izadi F, Amini M: Peripheral neuropathy in type 2 diabetes mellitus in Isfahan, Iran: prevalence and risk factors. Acta Neurol Scand 2006, 114: 384–391. 10.1111/j.1600-0404.2006.00716.xCrossRefPubMed

25.

YazdanPanah P, Ghaffarian Shirazi HR, Hatami Pour Y, Shariati Nia F, Vafaei F: Prevalence of peripheral neuropathy in patients of type 2 diabetes mellitus in Dena township in 2004. Armaghan Denesh Yasuj Univ Med Sci 2006, 11: 75–81.

26.

Madani SP, Larijani B, Erfani MH, Heshmat R: Comparison of clinical criteria with neurophysiologic findings of Sural nerve in diagnosis of diabetic peripheral neuropathy. Iran J Diabetes Lipid Disord 2006, 3: 135–140.

27.

Ranjbar Omrani G, Soveid M, Rajaei H, Sadegholvaad AS: The incidence of chronic diabetic complications during a 12 years period in patients referring to clinics of Shiraz University of Medical Sciences. Iran J Diabetes Lipid Disord 2002, 2: 53–53.

28.

Sarshar N, Chamanzari H: The survey of complications in the patients of Gonabad Diabetes Clinic. Ofogh-e Danesh. J Gonabad Uni Med Sci Health Services 2003, 9: 62–69.

29.

Tegha M, Soltanzadeh A, Abdollahi M, Kazemi M: The investigation of diabetic polyneuropathy and related factors in diabetic patients refereed to diabetes clinic of Shariati hospital. Iran J Neurol 2004, 3: 9–16.

30.

Rezvani MR, Moasheri N, Soltani M, Fardin Far S: Study of relative frequency of diabetes.complications among hospitalized patient in Imam Reza and Vali-Asr hospitals, Birjand, 2001. J Birjand Univ Med 2003, 9: 27–29.

31.

Habibi Moeini AS, Navaei L, Azizi F: Micro- and macrovascular diabetic complications in NIDDM: a population-based, case-control study. Iranian Endo Metab J 1999, 1: 38–47.

32.

Young MJ, Boulton AJ, MacLeod AF, Williams DR, Sonksen PH: A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia 1993, 36: 150–154. 10.1007/BF00400697CrossRefPubMed

33.

Dyck PJ, Kratz KM, Karnes JL, Litchy WJ, Klein R, Pach JM, Wilson DM, O'Brien PC, Melton LJ, Service FJ: The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology 1993, 43: 817–824. 10.1212/WNL.43.4.817CrossRefPubMed

34.

Fedele D, Comi G, Coscelli C, Cucinotta D, Feldman EL, Ghirlanda G, Greene DA, Negrin P, Santeusanio F: A multicenter study on the prevalence of diabetic neuropathy in Italy. Ital Diabet Neuropathy Comm Diabetes Care 1997, 20: 836–843. 10.2337/diacare.20.5.836CrossRef

35.

Yagihashi S, Mizukami H, Sugimoto K: Mechanism of diabetic neuropathy: Where are we now and where to go? J Diabetes Invest 2011, 2: 18–32. 10.1111/j.2040-1124.2010.00070.xCrossRef

36.

Searls Y, Smirnova IV, Vanhoose L, Fegley B, Loganathan R, Stehno-Bittel L: Time-dependent alterations in rat macrovessels with type 1 diabetes. Exp Diabetes Res 2012, 2012: 278620. 10.1155/2012/278620CrossRefPubMedPubMedCentral

37.

Kitsios K, Tsapas A, Karagianni P: Glycemia and cardiovascular risk: challenging evidence based medicine. Hippokratia 2011, 15: 199–204.PubMedPubMedCentral

38.

Amini M, Parvaresh E: Prevalence of macro- and microvascular complications among patients with type 2 diabetes in Iran: a systematic review. Diabetes Res Clin Pract 2009, 83: 18–25. 10.1016/j.diabres.2008.10.010CrossRefPubMed

Title: Prevalence of diabetic peripheral neuropathy in Iran: a systematic review and meta-analysis
Authors: Sahar Sobhani
Hamid Asayesh
Farshad Sharifi
Shirin Djalalinia
Hamid Reza Baradaran
Seyed Masoud Arzaghi
Morteza Mansourian
Aziz Rezapoor
Hossein Ansari
Mohammad Parvaresh Masoud
Mostafa Qorbani
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Journal of Diabetes & Metabolic Disorders / Issue 1/2014
Electronic ISSN: 2251-6581
DOI: https://doi.org/10.1186/s40200-014-0097-y

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2014

Evaluation of oral mucosal epithelium in diabetic male patients by exfoliative cytology method

Effect of low dose ω-3 poly unsaturated fatty acids on cognitive status among older people: a double-blind randomized placebo-controlled study

TNF-α and IFN-γ gene variation and genetic susceptibility to type 1 diabetes and its microangiopathic complications

Body composition in adults with newly diagnosed type 2 diabetes: effects of metformin

Erratum to: Cross-country variation in additive effects of socio-economics, health behaviors, and comorbidities on subjective health of patients with diabetes

Effect of progressive pedometer based walking intervention on quality of life and general well being among patients with type 2 diabetes

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials