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01-12-2014 | Short Communication

Prevalence of atypical antipsychotic use in psychiatric outpatients: comparison of women of childbearing age with men

Authors: Ulas Çamsarı, Adele C. Viguera, Laurel Ralston, Ross J. Baldessarini, Lee S. Cohen

Published in: Archives of Women's Mental Health | Issue 6/2014

Abstract

To characterize current treatment practices, we compared the use of atypical antipsychotic drugs among women of childbearing age to men based on electronic medical records of 1073 hospital-based psychiatric outpatients given at least one second-generation antipsychotic drug. One quarter of psychiatric outpatients sampled were prescribed at least one atypical antipsychotic, in more than half of cases for off-label indications. Women were significantly more likely than men to be diagnosed with mood or anxiety disorders than psychotic disorders and to be prescribed quetiapine (60.7 vs. 48.0 %) or aripiprazole (31.2 vs. 23.9 %), but less likely risperidone (15.8 vs. 26.1 %) or ziprasidone (10 vs. 14 %).

Abel KM (2013) Fetal antipsychotic exposure in a changing landscape: seeing the future. Br J Psychiatry 202(5):321–323PubMedCrossRef

Ajmal A, Joffe H, Nachtigall LB (2014) Psychotropic-induced hyperprolactinemia: a clinical review. Psychosomatics 55(1):29–36PubMedCrossRef

Alexander GC, Gallagher SA, Mascola A, Moloney RM, Stafford RS (2011) Increasing off-label use of antipsychotic medications in the United States, 1995–2008. Pharmacoepidemiol Drug Saf 20(2):177–184PubMedCentralPubMedCrossRef

Baldessarini RJ (2013) Chemotherapy in psychiatry, 3rd edn. Springer Press, New YorkCrossRef

Cunnington M, Messenheimer J (2008) Pregnancy registries: strengths, weaknesses, and bias: interpretation of pregnancy data. Int Rev Neurobiol 83:283–304PubMedCrossRef

Habermann F, Fritzsche J, Fuhlbrück F, Wacker E, Allignol A, Weber-Schoendorfer C, Meister R, Schaefer C (2013) Atypical antipsychotic drugs and pregnancy outcome: prospective, cohort study. J Clin Psychopharmacol 33(4):453–462PubMedCrossRef

Johnson KC, LaPrairie JL, Brennan P, Stowe ZN, Newport DJ (2012) Prenatal antipsychotic exposure and neuromotor performance during infancy. Arch Gen Psychiatry 69(8):787–794PubMedCrossRef

Katzan I, Speck M, Dopler C, Urchek J, Bielawski K, Dunphy C, Jehi L, Bae C, Parchman A (2011) The knowledge program: an innovative, comprehensive electronic data capture system and warehouse. AMIA Annu Symp Proc 2011:683–692PubMedCentralPubMed

Kennedy DL, Uhl K, Kweder SL (2004) Pregnancy exposure registries. Drug Saf 27(4):215–228PubMedCrossRef

McKenna K, Koren G, Tetelbaum M, Wilton L, Shakir S, Diav-Citrin O, Levinson A, Zipursky RB, Einarson A (2005) Pregnancy outcome of women using atypical antipsychotic drugs: prospective comparative study. J Clin Psychiatry 66(4):444–449PubMedCrossRef

Nasrallah HA (2006) Metabolic findings from the CATIE trial and their relation to tolerability. CNS Spectr 11(7 Suppl 7):32–39PubMed

Reis M, Källén B (2008) Maternal use of antipsychotics in early pregnancy and delivery outcome. J Clin Psychopharmacol 28(3):279–288PubMedCrossRef

Sadowski A, Todorow M, Yazdani-Brojeni P, Koren G, Nulman I (2013) Pregnancy outcomes following maternal exposure to second-generation antipsychotics given with other psychotropic drugs: cohort study. BMJ Open 3(7):e003062PubMedCentralPubMedCrossRef

Thomas SH, Yates LM (2012) Prescribing without evidence—pregnancy. Br J Clin Pharmacol 74(4):691–697PubMedCentralPubMedCrossRef

Toh S, Li Q, Cheetham TC, Cooper WO, Davis RL, Dublin S, Hammad TA, Li DK, Pawloski PA, Pinheiro SP, Raebel MA, Scott PE, Smith DH, Bobo WV, Lawrence JM, Dashevsky I, Haffenreffer K, Avalos LA, Andrade SE (2013) Prevalence and trends in the use of antipsychotic medications during pregnancy in the US, 2001–2007: population-based study of 585,615 deliveries. Arch Womens Ment Health 16(2):149–157PubMedCentralPubMedCrossRef

Tomson T, Battino D, Craig J, Hernandez-Diaz S, Holmes LB, Lindhout D, Morrow J, French J, ILAE Commission on Therapeutic Strategies (2010) Pregnancy registries: differences, similarities, and possible harmonization. Epilepsia 5(5):909–915CrossRef

Vajda FJ (2010) The Australian pregnancy register of anti-epileptic drugs: 10 years of progress. J Clin Neurosci 17(12):1485–1488PubMedCrossRef

Wichman CL (2009) Atypical antipsychotic use in pregnancy: retrospective review. Arch Womens Ment Health 12(1):53–57PubMedCrossRef

Title: Prevalence of atypical antipsychotic use in psychiatric outpatients: comparison of women of childbearing age with men
Authors: Ulas Çamsarı
Adele C. Viguera
Laurel Ralston
Ross J. Baldessarini
Lee S. Cohen
Publication date: 01-12-2014
Publisher: Springer Vienna
Published in: Archives of Women's Mental Health / Issue 6/2014
Print ISSN: 1434-1816
Electronic ISSN: 1435-1102
DOI: https://doi.org/10.1007/s00737-014-0465-0

At a glance: The STEP trials

Springer Medicine

Prevalence of atypical antipsychotic use in psychiatric outpatients: comparison of women of childbearing age with men

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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