Top

Graefe's Archive for Clinical and Experimental Ophthalmology

Published in:

Open Access 01-02-2009 | Glaucoma

Prevalence and determinants of non-adherence to topical hypotensive treatment in Dutch glaucoma patients

Authors: Christine M. G. Olthoff, Juliette G. M. M. Hoevenaars, Bart W. van den Borne, Carroll A. B. Webers, Jan S. A. G. Schouten

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 2/2009

Abstract

Background

To assess the prevalence and determinants of non-adherence to topical hypotensive treatment in glaucoma patients in order to support interventions targeting enhancement of patient adherence.

Methods

One-hundred and sixty-six glaucoma patients, recruited by nationwide multi-stage sampling, filled in an extensive and carefully developed questionnaire covering various theoretically relevant determinants of patient adherence which were categorized as psychosocial aspects, barriers and skills.

Results

Prevalence of self-reported non-adherence was 27.3%. Younger patients (<55 years of age) had a higher risk of being non-adherent. Forgetfulness, unavailability of eye drops and difficulties with holding the bottle above the eye when applying the eye drops were the most cited reasons for non-adherence. Fifty percent of the patients indicated that they required more information on the correct administration of eye drops. There was no association between non-adherence and sex, level of education, type of insurance, duration of disease or family history of glaucoma.

Conclusions

Non-adherence to topical glaucoma medication is fairly common. Aids that minimize forgetfulness and delivery systems facilitating the delivery of medications to the eye could be considered to enhance patient adherence before advancing to other therapies with additional risks and costs.

Busche S, Gramer E (1997) Verbesserung der Augentropfenapplikation und Compliance bei Glaukompatienten; eine klinische Studie. Klin Monatsbl Augenheilkd 211:257–262PubMedCrossRef

Forsman E, Kivel T, Vesti E (2007) Lifetime visual disability in open-angle glaucoma and ocular hypertension. J Glaucoma 16:313–319PubMedCrossRef

Konstas AGP, Maskaleris G, Gratsonidis S, Sardelli C (2000) Compliance and viewpoint of glaucoma patients in Greece. Eye 14:752–756PubMed

Lee DA, Fechtner RD, Fiscella RG, Singh K, Stewart WC (2000) Emerging perspectives on glaucoma: highlights of a roundtable discussion. Am J Ophthalmol 130:S1–S11PubMedCrossRef

Zimmerman TJ, Zalta AH (1983) Facilitating patient compliance in glaucoma therapy. Surv Ophthalmol 28:252–257PubMedCrossRef

DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW (2002) Patient adherence and medical treatment outcomes; a meta-analysis. Med Care 40:794–811PubMedCrossRef

Deokule S, Sadiq S, Shah S (2004) Chronic open angle glaucoma: patient awareness of the nature of the disease, topical medication, compliance and the prevalence of systemic symptoms. Ophthal Physiol Opt 24:9–15CrossRef

Gurwitz JH, Yeomans SM, Glynn RJ, Lewis BE, Levin R, Avorn J (1998) Patient noncompliance in the managed care setting; the case of medical therapy for glaucoma. Med Care 36:357–369PubMedCrossRef

Olthoff CMG, Schouten JSAG, Van de Borne BW, Webers CAB (2005) Noncompliance with ocular hypotensive treatment in patients with glaucoma or ocular hypertension. Ophthalmology 112:953–961PubMedCrossRef

10.

Rotchford AP, Murphy KM (1998) Compliance with timolol treatment in glaucoma. Eye 12:234–236PubMed

11.

Tsai JC, McClure CA, Ramos SE, Schlundt DG, Pichert JW (2003) Compliance barriers in glaucoma: a systematic classification. J Glaucoma 12:393–398PubMedCrossRef

12.

Taylor S, Galbraith S, Mills R (2002) Causes of non-compliance with drug regimens in glaucoma patients: a qualitative study. J Ocul Pharmacol Ther 18:401–409PubMedCrossRef

13.

Sleath B, Robin AL, Covert D, Byrd JE, Tudor G, Svarstad B (2006) Patient-reported behavior and problems in using glaucoma medications. Ophthalmology 113:431–436PubMedCrossRef

14.

Elliot R, Barber N, Horne R (2005) Cost-effectiveness of adherence-enhancing interventions: a quality assessment of the evidence. Ann Pharmacother 39:508–515CrossRef

15.

Meertens RM, Schaalma H, Brug J, De Vries N (2000) Determinanten van gedrag [Determinants of behavior]. In: Brug J, Schaalma H, Kok G, Meertens RM, Van der Molen HT (Eds) Gezondheidsvoorlichting en Gedragsverandering; een Planmatige Aanpak [Health promotion and behavior change: a systematic approach]. Van Gorcum, Assen Netherlands, pp 55–72

16.

Amon M, Menapace R, Wedrich A, Radax U (1990) Aspekte der Betreuung von Glaukompatienten und deren Auswirkung auf die Compliance. Spektrum Augenheilkd 4:5–8

17.

Bour T, Blanchard F, Segal A (1993) [Therapeutic observance and life of patients with primary open-angle glaucoma. Apropos of 341 cases in the department of Marne]. J Fr Ophtalmol 16:380–391(in French)PubMed

18.

Chang J, Lee D, Petursson G, Spaeth G, Zimmerman T, Hoskins H, Mills R, Brown R, Kass M, Lue J (1991) The effect of a glaucoma medication reminder cap on patient compliance and intraocular pressure. J Ocul Pharmacol 7:117–124PubMed

19.

Laster S, Martin J, Fleming J (1996) The effect of a medication alarm device on patient compliance with topical pilocarpine. J Am Optom Assoc 67:654–658PubMed

20.

MacKean JM, Elkington AR (1983) Compliance with treatment of patients with chronic open-angle glaucoma. Br J Ophthalmol 67:46–49PubMedCrossRef

21.

Patel SC, Spaeth GL (1995) Compliance in patients prescribed eyedrops for glaucoma. Ophthalmic Surg 26:233–236PubMed

22.

Bloch S, Rosenthal AR, Friedman DS, Caldarolla P (1977) Patient compliance in glaucoma. Br J Ophthalmol 61:531–534PubMedCrossRef

23.

Winfield AJ, Jessiman D, Esakowitz L (1990) A study of the causes of non-compliance by patients prescribed eyedrops. Br J Ophthalmol 74:477–480PubMedCrossRef

24.

Gurwitz JH, Glynn RJ, Monane M, Everitt DE, Gilden D, Smith N, Avorn J (1993) Treatment for glaucoma: adherence by the elderly. Am J Public Health 83:711–716PubMedCrossRef

25.

Kass MA, Meltzer DW, Gordon M, Cooper D, Goldberg J (1986) Compliance with topical pilocarpine treatment. Am J Ophthalmol 101:515–523PubMed

26.

DiMatteo MR (2004) Variations in patients’ adherence to medical recommendations; a quantitative review of 50 years of research. Med Care 42:200–209PubMedCrossRef

27.

Oldenmenger W, Echteld M, Wit de R, Sillevis Smit P, Stronks D, Stoter G, Rijt van der C (2007) Analgesic adherence measurement in cancer patients: comparison between electronic monitoring and diary. J Pain Symptom Manage 34:639–647PubMedCrossRef

28.

Hugen P, Langebeek N, Burger D, Zomer B, Leusen van R, Schuurman R, Koopmans P, Hekster Y (2002) Assessment of adherence to HIV protease inhibitors: comparison and combination of various methods, including MEMS (electronic monitoring), patient and nurse report, and therapeutic drug monitoring. J Acquir Immune Defic Syndr 30:324–334PubMed

29.

Kosoko O, Quigley HA, Vitale S, Enger C, Kerrigan L, Tielsch JM (1998) Risk factors for noncompliance with glaucoma follow-up visits in a residents's eye clinic. Ophthalmology 105:2105–2111PubMedCrossRef

30.

Brown M, Brown G, Spaeth G (1984) Improper topical self-administration of ocular medication among patients with glaucoma. Can J Ophthalmol 19:2–5PubMed

31.

Dietlein TS (2006) Glaukom im Alter; Barrieren fur Aufklaerung und Compliance. Ophthalmologe 103:755–758PubMedCrossRef

32.

Robin AL, Covert D (2005) Does adjunctive glaucoma therapy affect adherence to the initial primary therapy? Ophthalmology 112:863–868PubMedCrossRef

33.

Robin A, Novack G, Covert D, Crockett R, Marcic T (2007) Adherence in glaucoma: objective measurements of once-daily and adjunctive medication use. Am J Ophthalmol 144:533–540PubMedCrossRef

34.

Mansukani SS (2002) Improving adherence to drug-treatment regimens for glaucoma. Manag Care 11:49–53PubMed

35.

Kripalani S, Yao X, Haynes B (2007) Interventions to enhance medication adherence in chronic medical conditions; a systematic review. Arch Intern Med 167:540–550PubMedCrossRef

36.

Dulmen van S, Sluijs E, Dijk van L, Ridder de D, Heerdink R, Bensing J (2007) Patient adherence to medical treatment: a review of reviews. BMC Health Serv Res 7:55CrossRef

37.

Stewart WC, Konstas AGP, Pfeiffer N (2004) Patient and ophthalmologist attitudes concerning compliance and dosing in glaucoma treatment. J Ocul Pharmacol Ther 20:461–469PubMedCrossRef

38.

Buller AJ, Morgan LH, Hercules BL (2007) Patients prefer one-daily glaucoma drops. Graefes Arch Clin Exp Ophthalmol 245:293–294PubMedCrossRef

39.

Jampel HD, Schwartz GF, Robin AL, Abrams DA, Johnson E, Miller RB (2003) Patient preferences for eye drop characteristics. Arch Ophthalmol 121:540–546PubMedCrossRef

40.

Sclar D, Skaer T, Chin A (1991) Effectiveness of the C Cap in promoting prescription refill compliance among patients with glaucoma. Clin Ther 13:396–400PubMed

41.

Norell SE (1979) Improving medication compliance: a randomised clinical trial. Br Med J 2:1031–1033PubMedCrossRef

42.

Flowers B, Wand M, Piltz-Seymour J, Berke S, Day D, Teague J, Smoot T, Landry T, Bergamini M, Mallick S (2006) Patients’ and physicians’ perceptions of the Travoprost dosing aid: an open-label, multicenter study of adherence with prostaglandin analogue therapy for open-angle glaucoma or ocular hypertension. Clin Ther 28:1803–1811PubMedCrossRef

43.

Boden C, Sit A, Weinreb RN (2006) Accuracy of an electronic monitoring and reminder device for use with travoprost eye drops. J Glaucoma 15:30–34PubMedCrossRef

44.

Kharod BV, Johnson PB, Nesti HA, Rhee DJ (2006) Effect of written instructions on accuracy of self-reporting medication regimen in glaucoma patients. J Glaucoma 15:244–247PubMedCrossRef

45.

Lefante JJ, Harmon GN, Roy W, Fontenot S, Brown K, Webber L (2005) The effect of medication reviews in a rural community pharmacy assistance program: the cenla medication access program. J Pharm Pract 18:486–492CrossRef

46.

Roter DL, Hall JA, Merisca R, Nordstrom B, Cretin D, Svarstad B (1998) Effectiveness of interventions to improve patient compliance; a meta-analysis. Med Care 36:1138–1161PubMedCrossRef

47.

Peterson A, Takiya L, Finley R (2003) Meta-analysis of trials of interventions to improve medication adherence. Am J Health Syst Pharm 60:657–665PubMed

Title: Prevalence and determinants of non-adherence to topical hypotensive treatment in Dutch glaucoma patients
Authors: Christine M. G. Olthoff
Juliette G. M. M. Hoevenaars
Bart W. van den Borne
Carroll A. B. Webers
Jan S. A. G. Schouten
Publication date: 01-02-2009
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 2/2009
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-008-0944-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prevalence and determinants of non-adherence to topical hypotensive treatment in Dutch glaucoma patients

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 2/2009

Are intravitreal bevacizumab and ranibizumab effective in a rat model of choroidal neovascularization?

Physiology of vitreous surgery

Ceramide production associated with retinal apoptosis after retinal detachment

The effect of clonidine on VEGF expression in human retinal pigment epithelial cells (ARPE-19)

Fundus autofluorescence in serpiginous choroiditis

Jonathan D. Trobe: Neuro-Ophthalmology (Rapid Diagnosis in Ophthalmology Series)