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Critical Care
Published in: Critical Care 1/2015

Open Access 01-12-2015 | Letter

Presepsin and sepsis-induced acute kidney injury treated with continuous renal replacement therapy: will another promising biomarker bite the dust?

Authors: Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

Published in: Critical Care | Issue 1/2015

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Excerpt

A recent meta-analysis published in Critical Care proposed presepsin as a novel valuable biomarker for discriminating systemic inflammation from true sepsis [1]. Unfortunately, this excellent paper did not provide information about the occurrence and eventual treatment of acute kidney injury (AKI) in the studied population. The kidney is one of the most frequently afflicted organs during sepsis and AKI may complicate up to half of the cases of blood culture-positive septic shock [2]. …
Literature
1.
Zhang X, Liu D, Liu YN, Wang R, Xie LX. The accuracy of presepsin (sCD14-ST) for the diagnosis of sepsis in adults: a meta-analysis. Crit Care. 2015;19:323.CrossRef
2.
Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the Systemic Inflammatory Response Syndrome (SIRS): a prospective study. JAMA. 1995;273:117–23.CrossRef
3.
Nagata T, Yasuda Y, Ando M, Abe T, Katsuno T, Kato S, et al. Clinical impact of kidney function on presepsin levels. PLoS One. 2015;10, e0129159.CrossRef
4.
Honore PM, Jacobs R, Hendrickx I, De Waele E, Van Gorp V, Spapen HD. ‘Biomarking’ infection during continuous renal replacement therapy: still relevant? Crit Care. 2015;19:232.CrossRef
5.
Honore PM, Jacobs R, Joannes-Boyau O, De Regt J, De Waele E, van Gorp V, et al. Newly designed CRRT membranes for sepsis and SIRS—a pragmatic approach for bedside intensivists summarizing the more recent advances: a systematic structured review. ASAIO J. 2013;59:99–106.CrossRef
Metadata
Title
Presepsin and sepsis-induced acute kidney injury treated with continuous renal replacement therapy: will another promising biomarker bite the dust?
Authors
Patrick M. Honore
Rita Jacobs
Inne Hendrickx
Elisabeth De Waele
Viola Van Gorp
Herbert D. Spapen
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-1146-8

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