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Pediatric Nephrology

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01-01-2015 | Original Article

Presentation and outcome of paediatric membranous non-proliferative lupus nephritis

Authors: Boris Hugle, Earl D. Silverman, Pascal N. Tyrrell, Elizabeth A. Harvey, Diane Hébert, Susanne M. Benseler

Published in: Pediatric Nephrology | Issue 1/2015

Abstract

Background

Studies of paediatric patients with membranous lupus nephritis (MLN) have yielded variable results, mostly due to the inclusion of mixed, i.e. proliferative nephritis. The aim of this study was to describe clinical and laboratory findings at the diagnosis of paediatric non-proliferative MLN, report the outcome and identify predictors of remission.

Methods

A single-center cohort study of consecutive children diagnosed with non-proliferative MLN was performed. Clinical and laboratory measures and treatment regimens were obtained in prospective standardized assessments. Renal outcome was measured by renal parameters and steroid requirement. Predictors for remission and time to remission were determined.

Results

A total of 30 children were identified with a median follow-up time 4.1 years. Of 21 patients followed for more than 2 years, 19 (90 %) achieved clinical remission, and 16 (76 %) achieved a state of maintained clinical remission on low-dose prednisone. Three patients developed proliferative nephritis on subsequent renal biopsy. Lower albumin at the time of biopsy was correlated with a lower rate of remission and longer time to remission.

Conclusions

Among our paediatric patient cohort the outcome of non-proliferative MLN in systemic lupus erythematosus was good. The majority of patients did not require aggressive immunosuppressive treatment to reach a stable disease state on low-dose steroid treatment.

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Title: Presentation and outcome of paediatric membranous non-proliferative lupus nephritis
Authors: Boris Hugle
Earl D. Silverman
Pascal N. Tyrrell
Elizabeth A. Harvey
Diane Hébert
Susanne M. Benseler
Publication date: 01-01-2015
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 1/2015
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-014-2908-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Presentation and outcome of paediatric membranous non-proliferative lupus nephritis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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