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Drugs - Real World Outcomes

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Open Access 01-12-2017 | Original Research Article

Prescription of Sedative Drugs During Hospital Stay: A Swiss Prospective Study

Authors: Laurence Schumacher, Maria Dobrinas, Damien Tagan, Annelore Sautebin, Anne-Laure Blanc, Nicolas Widmer

Published in: Drugs - Real World Outcomes | Issue 4/2017

Abstract

Background

In recent years, the number of prescriptions for sedative drugs has increased significantly, as has their long-term use. Moreover, sedative use is frequently initiated during hospital stays.

Objectives

This study aimed to describe new prescriptions of sedative drugs during hospital stays and evaluate their maintenance as discharge medication.

Methods

This observational prospective study took place in an internal medicine ward of a Swiss hospital over a period of 3 months in 2014. Demographic (age, sex, diagnosis, comorbidities) and medication data [long-term use of sedative drugs, new regular or pro re nata (‘as needed’) prescriptions of sedative drugs, drug-related problems] were collected. Sedative medications included: benzodiazepines, Z-drugs, antihistamines, antidepressants, neuroleptics, herbal drugs, and clomethiazole. McNemar’s test was used for comparison.

Results

Of 290 patients included, 212 (73%) were over 65 years old and 169 (58%) were women; 34% (n = 98) were using sedative drugs long term before their hospital stay, and 44% (n = 128) had a prescription for sedative drugs at discharge—a 10% increase (p < 0.05). Sedative drugs were newly prescribed to 37% (n = 108) of patients during their stay. Among these, 37% (n = 40) received a repeat prescription at discharge. Over half of the sedative drugs were prescribed within 24 h of admission. Drug-related problems were detected in 76% of new prescriptions, of which 90% were drug–drug interactions.

Conclusion

This study showed that hospital stays increased the proportion of patients who were prescribed a sedative drug at discharge by 10% (absolute increase). These prescriptions may generate long-term use and expose patients to drug-related problems. Promoting alternative approaches for managing insomnia are recommended.

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Title: Prescription of Sedative Drugs During Hospital Stay: A Swiss Prospective Study
Authors: Laurence Schumacher
Maria Dobrinas
Damien Tagan
Annelore Sautebin
Anne-Laure Blanc
Nicolas Widmer
Publication date: 01-12-2017
Publisher: Springer International Publishing
Published in: Drugs - Real World Outcomes / Issue 4/2017
Print ISSN: 2199-1154
Electronic ISSN: 2198-9788
DOI: https://doi.org/10.1007/s40801-017-0117-6

2024 ASCO Annual Meeting

Springer Medicine

Prescription of Sedative Drugs During Hospital Stay: A Swiss Prospective Study

Abstract

Background

Objectives

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Objectives

Methods

Results

Conclusion

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