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Published in: Knee Surgery, Sports Traumatology, Arthroscopy 8/2023

22-02-2023 | KNEE

Preoperative factors associated with failure to reach the patient acceptable symptom state after anterior cruciate ligament reconstruction in patients aged 40 and older

Authors: Richard N. Puzzitiello, Stephen M. Sylvia, Gabriel S. Perrone, Jack T. Bragg, John C. Richmond, Matthew J. Salzler

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 8/2023

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Abstract

Purpose

To perform a predictive analysis to identify preoperative patient factors associated with failure to achieve a newly defined patient acceptable symptom state (PASS) for the International Knee Documentation Committee (IKDC) Score after anterior cruciate ligament reconstruction (ACLR) in patients aged ≥ 40 years with a minimum of 2-year follow-up.

Methods

This was a secondary analysis of a retrospective review of all patients aged 40 years or older receiving a primary allograft ACLR at a single institution between the years of 2005 and 2016, with 2-year minimum follow-up. Using an updated PASS threshold of 66.7 for the International Knee Documentation Committee (IKDC) score previously established for this patient cohort, a univariate and multivariate analysis was performed to identify preoperative patient characteristics predictive of failure to achieve PASS.

Results

A total of 197 patients with a mean follow-up of 6.2 ± 2.1 years (range 2.7 – 11.2) were included in the analysis (48.5 ± 5.6 years, 51.8% female, Body Mass Index (BMI) 25.9 ± 4.4). PASS was achieved by 162 patients (82.2%). Patients who failed to achieve PASS more often had lateral compartment cartilage defects (P = 0.001) and lateral meniscus tears (P = 0.004), higher BMIs (P = 0.004), and Workers’ Compensation status (P = 0.043) on univariable analysis. Factors predictive of failure to achieve PASS on multivariable analysis included BMI and lateral compartment cartilage defect (OR 1.12 [1.03–1.23], P = 0.013; OR 5.1 [1.87–13.9], P = 0.001).

Conclusion

Among patients ≥ 40 years who receive a primary allograft ACLR, patients who fail to achieve PASS more often had lateral compartment cartilage defects and higher BMIs.

Level of evidence

Level IV.
Literature
1.
go back to reference Bedi A, Chen T, Santner TJ, El-Amin S, Kelly NH, Warren RF et al (2013) Changes in dynamic medial tibiofemoral contact mechanics and kinematics after injury of the anterior cruciate ligament: a cadaveric model. Proc Inst Mech Eng H 227:1027–1037CrossRefPubMedPubMedCentral Bedi A, Chen T, Santner TJ, El-Amin S, Kelly NH, Warren RF et al (2013) Changes in dynamic medial tibiofemoral contact mechanics and kinematics after injury of the anterior cruciate ligament: a cadaveric model. Proc Inst Mech Eng H 227:1027–1037CrossRefPubMedPubMedCentral
2.
go back to reference Beletsky A, Naami E, Lu Y, Polce EM, Nwachukwu BU, Okoroha KR et al (2021) The patient acceptable symptomatic state in primary anterior cruciate ligament reconstruction: predictors of achievement. Arthroscopy 37:600–605CrossRefPubMed Beletsky A, Naami E, Lu Y, Polce EM, Nwachukwu BU, Okoroha KR et al (2021) The patient acceptable symptomatic state in primary anterior cruciate ligament reconstruction: predictors of achievement. Arthroscopy 37:600–605CrossRefPubMed
3.
go back to reference Best MJ, Zikria BA, Wilckens JH (2021) Anterior cruciate ligament injuries in the older athlete. Sports Health 13:285–289CrossRefPubMed Best MJ, Zikria BA, Wilckens JH (2021) Anterior cruciate ligament injuries in the older athlete. Sports Health 13:285–289CrossRefPubMed
4.
go back to reference Borchers JR, Kaeding CC, Pedroza AD, Huston LJ, Spindler KP, Wright RW (2011) Intra-articular findings in primary and revision anterior cruciate ligament reconstruction surgery: a comparison of the MOON and MARS study groups. Am J Sports Med 39:1889–1893CrossRefPubMedPubMedCentral Borchers JR, Kaeding CC, Pedroza AD, Huston LJ, Spindler KP, Wright RW (2011) Intra-articular findings in primary and revision anterior cruciate ligament reconstruction surgery: a comparison of the MOON and MARS study groups. Am J Sports Med 39:1889–1893CrossRefPubMedPubMedCentral
5.
go back to reference Brown CA, McAdams TR, Harris AH, Maffulli N, Safran MR (2013) ACL reconstruction in patients aged 40 years and older: a systematic review and introduction of a new methodology score for ACL studies. Am J Sports Med 41:2181–2190CrossRefPubMed Brown CA, McAdams TR, Harris AH, Maffulli N, Safran MR (2013) ACL reconstruction in patients aged 40 years and older: a systematic review and introduction of a new methodology score for ACL studies. Am J Sports Med 41:2181–2190CrossRefPubMed
6.
go back to reference Buller LT, Best MJ, Baraga MG, Kaplan LD (2014) Trends in anterior cruciate ligament reconstruction in the United States. Orthop J Sports Med 3:2325967114563664PubMedPubMedCentral Buller LT, Best MJ, Baraga MG, Kaplan LD (2014) Trends in anterior cruciate ligament reconstruction in the United States. Orthop J Sports Med 3:2325967114563664PubMedPubMedCentral
7.
go back to reference Capogna BM, Mahure SA, Mollon B, Duenes ML, Rokito AS (2020) Young age, female gender, Caucasian race, and workers’ compensation claim are risk factors for reoperation following arthroscopic ACL reconstruction. Knee Surg Sports Traumatol Arthrosc 28:2213–2223CrossRefPubMed Capogna BM, Mahure SA, Mollon B, Duenes ML, Rokito AS (2020) Young age, female gender, Caucasian race, and workers’ compensation claim are risk factors for reoperation following arthroscopic ACL reconstruction. Knee Surg Sports Traumatol Arthrosc 28:2213–2223CrossRefPubMed
8.
go back to reference Ciccotti MG, Lombardo SJ, Nonweiler B, Pink M (1994) Non-operative treatment of ruptures of the anterior cruciate ligament in middle-aged patients. Results after long-term follow-up. J Bone Joint Surg Am 76:1315–1321CrossRefPubMed Ciccotti MG, Lombardo SJ, Nonweiler B, Pink M (1994) Non-operative treatment of ruptures of the anterior cruciate ligament in middle-aged patients. Results after long-term follow-up. J Bone Joint Surg Am 76:1315–1321CrossRefPubMed
9.
go back to reference Corona K, Ronga M, Morris BJ, Tamini J, Zappalà G, Cherubino M et al (2020) Comparable clinical and functional outcomes after anterior cruciate ligament reconstruction over and under 40 years of age. Knee Surg Sports Traumatol Arthrosc 28:1932–1945CrossRefPubMed Corona K, Ronga M, Morris BJ, Tamini J, Zappalà G, Cherubino M et al (2020) Comparable clinical and functional outcomes after anterior cruciate ligament reconstruction over and under 40 years of age. Knee Surg Sports Traumatol Arthrosc 28:1932–1945CrossRefPubMed
10.
go back to reference Cristiani R, Mikkelsen C, Edman G, Forssblad M, Engström B, Stålman A (2020) Age, gender, quadriceps strength and hop test performance are the most important factors affecting the achievement of a patient-acceptable symptom state after ACL reconstruction. Knee Surg Sports Traumatol Arthrosc 28:369–380CrossRefPubMed Cristiani R, Mikkelsen C, Edman G, Forssblad M, Engström B, Stålman A (2020) Age, gender, quadriceps strength and hop test performance are the most important factors affecting the achievement of a patient-acceptable symptom state after ACL reconstruction. Knee Surg Sports Traumatol Arthrosc 28:369–380CrossRefPubMed
11.
go back to reference de Moraes VY, Godin K, Tamaoki MJ, Faloppa F, Bhandari M, Belloti JC (2012) Workers’ compensation status: does it affect orthopaedic surgery outcomes? A meta-analysis PLoS One 7:e50251CrossRefPubMed de Moraes VY, Godin K, Tamaoki MJ, Faloppa F, Bhandari M, Belloti JC (2012) Workers’ compensation status: does it affect orthopaedic surgery outcomes? A meta-analysis PLoS One 7:e50251CrossRefPubMed
12.
go back to reference Docter S, Fathalla Z, Lukacs MJ, Khan MCM, Jennings M, Liu S-H et al (2021) Interpreting patient-reported outcome measures in orthopaedic surgery: a systematic review. J Bone Joint Surg 103(2):185–190CrossRefPubMed Docter S, Fathalla Z, Lukacs MJ, Khan MCM, Jennings M, Liu S-H et al (2021) Interpreting patient-reported outcome measures in orthopaedic surgery: a systematic review. J Bone Joint Surg 103(2):185–190CrossRefPubMed
14.
go back to reference Gupta R, Kapoor A, Soni A, Khatri S, Masih GD (2020) Anterior cruciate ligament tear due to non-contact mode of injury associated with higher incidence of meniscal and chondral damage. J Clin Orthop Trauma 11:S342-s345CrossRefPubMed Gupta R, Kapoor A, Soni A, Khatri S, Masih GD (2020) Anterior cruciate ligament tear due to non-contact mode of injury associated with higher incidence of meniscal and chondral damage. J Clin Orthop Trauma 11:S342-s345CrossRefPubMed
15.
go back to reference Harris JD, Brand JC, Cote MP, Faucett SC, Dhawan A (2017) Research pearls: the significance of statistics and perils of pooling. part 1: clinical versus statistical significance. Arthrosc: J Arthrosc Relat Surg 33:1102–1112CrossRef Harris JD, Brand JC, Cote MP, Faucett SC, Dhawan A (2017) Research pearls: the significance of statistics and perils of pooling. part 1: clinical versus statistical significance. Arthrosc: J Arthrosc Relat Surg 33:1102–1112CrossRef
16.
go back to reference Imhauser C, Mauro C, Choi D, Rosenberg E, Mathew S, Nguyen J et al (2013) Abnormal tibiofemoral contact stress and its association with altered kinematics after center-center anterior cruciate ligament reconstruction: an in vitro study. AM J Sports Med 41:815–825CrossRefPubMedPubMedCentral Imhauser C, Mauro C, Choi D, Rosenberg E, Mathew S, Nguyen J et al (2013) Abnormal tibiofemoral contact stress and its association with altered kinematics after center-center anterior cruciate ligament reconstruction: an in vitro study. AM J Sports Med 41:815–825CrossRefPubMedPubMedCentral
17.
go back to reference Kawashima I, Tsukahara T, Sakai T, Kawai R, Ishizuka S, Hiraiwa H et al (2021) Delayed anterior cruciate ligament reconstruction increases the incidence of medial meniscal bucket handle tears and medial compartment chondral injuries in patients aged 40 years and older. Arch Orthop Trauma Surg 141:971–975CrossRefPubMed Kawashima I, Tsukahara T, Sakai T, Kawai R, Ishizuka S, Hiraiwa H et al (2021) Delayed anterior cruciate ligament reconstruction increases the incidence of medial meniscal bucket handle tears and medial compartment chondral injuries in patients aged 40 years and older. Arch Orthop Trauma Surg 141:971–975CrossRefPubMed
19.
go back to reference Kim DK, Park G, Kuo LT, Park WH (2019) Patients older than 50 years had similar results of knee strength and anteroposterior stability after ACL reconstruction compared to younger patients. Knee Surg Sports Traumatol Arthrosc 27:230–238CrossRefPubMed Kim DK, Park G, Kuo LT, Park WH (2019) Patients older than 50 years had similar results of knee strength and anteroposterior stability after ACL reconstruction compared to younger patients. Knee Surg Sports Traumatol Arthrosc 27:230–238CrossRefPubMed
20.
go back to reference Kim KT, Kim HJ, Lee HI, Park YJ, Kang DG, Yoo JI et al (2018) A comparison of results after anterior cruciate ligament reconstruction in over 40 and under 40 years of age: a meta-analysis. Knee Surg Relat Res 30:95–106CrossRefPubMedPubMedCentral Kim KT, Kim HJ, Lee HI, Park YJ, Kang DG, Yoo JI et al (2018) A comparison of results after anterior cruciate ligament reconstruction in over 40 and under 40 years of age: a meta-analysis. Knee Surg Relat Res 30:95–106CrossRefPubMedPubMedCentral
21.
go back to reference Kim SJ, Park KH, Kim SH, Kim SG, Chun YM (2010) Anterior cruciate ligament reconstruction improves activity-induced pain in comparison with pain at rest in middle-aged patients with significant cartilage degeneration. Am J Sports Med 38:1343–1348CrossRefPubMed Kim SJ, Park KH, Kim SH, Kim SG, Chun YM (2010) Anterior cruciate ligament reconstruction improves activity-induced pain in comparison with pain at rest in middle-aged patients with significant cartilage degeneration. Am J Sports Med 38:1343–1348CrossRefPubMed
22.
go back to reference Kvist J, Filbay S, Andersson C, Ardern CL, Gauffin H (2020) Radiographic and symptomatic knee osteoarthritis 32 to 37 years after acute anterior cruciate ligament rupture. Am J Sports Med 48:2387–2394CrossRefPubMedPubMedCentral Kvist J, Filbay S, Andersson C, Ardern CL, Gauffin H (2020) Radiographic and symptomatic knee osteoarthritis 32 to 37 years after acute anterior cruciate ligament rupture. Am J Sports Med 48:2387–2394CrossRefPubMedPubMedCentral
23.
go back to reference Lie MM, Risberg MA, Storheim K, Engebretsen L, Øiestad BE (2019) What’s the rate of knee osteoarthritis 10 years after anterior cruciate ligament injury? An updated systematic review. Br J Sports Med 53:1162–1167CrossRefPubMed Lie MM, Risberg MA, Storheim K, Engebretsen L, Øiestad BE (2019) What’s the rate of knee osteoarthritis 10 years after anterior cruciate ligament injury? An updated systematic review. Br J Sports Med 53:1162–1167CrossRefPubMed
24.
go back to reference Mall NA, Chalmers PN, Moric M, Tanaka MJ, Cole BJ, Bach BR Jr et al (2014) Incidence and trends of anterior cruciate ligament reconstruction in the United States. Am J Sports Med 42:2363–2370CrossRefPubMed Mall NA, Chalmers PN, Moric M, Tanaka MJ, Cole BJ, Bach BR Jr et al (2014) Incidence and trends of anterior cruciate ligament reconstruction in the United States. Am J Sports Med 42:2363–2370CrossRefPubMed
25.
go back to reference Mall NA, Frank RM, Saltzman BM, Cole BJ, Bach BR Jr (2016) Results after anterior cruciate ligament reconstruction in patients older than 40 years: how do they compare with younger patients? A systematic review and comparison with younger populations. Sports Health 8:177–181CrossRefPubMed Mall NA, Frank RM, Saltzman BM, Cole BJ, Bach BR Jr (2016) Results after anterior cruciate ligament reconstruction in patients older than 40 years: how do they compare with younger patients? A systematic review and comparison with younger populations. Sports Health 8:177–181CrossRefPubMed
26.
go back to reference Muller B, Yabroudi MA, Lynch A, Lai CL, van Dijk CN, Fu FH et al (2016) Defining thresholds for the patient acceptable symptom state for the IKDC subjective knee form and KOOS for patients who underwent ACL reconstruction. Am J Sports Med 44:2820–2826CrossRefPubMed Muller B, Yabroudi MA, Lynch A, Lai CL, van Dijk CN, Fu FH et al (2016) Defining thresholds for the patient acceptable symptom state for the IKDC subjective knee form and KOOS for patients who underwent ACL reconstruction. Am J Sports Med 44:2820–2826CrossRefPubMed
27.
go back to reference Noyes FR, Barber-Westin SD (1997) A comparison of results of arthroscopic-assisted anterior cruciate ligament reconstruction between workers’ compensation and noncompensation patients. Arthrosc: J Arthrosc Relat Surg 13:474–484CrossRef Noyes FR, Barber-Westin SD (1997) A comparison of results of arthroscopic-assisted anterior cruciate ligament reconstruction between workers’ compensation and noncompensation patients. Arthrosc: J Arthrosc Relat Surg 13:474–484CrossRef
28.
go back to reference Orr MN, Klika AK, Gagnier JJ, Bhandari M, Piuzzi NS (2021) A call for a standardized approach to reporting patient-reported outcome measures: clinical relevance ratio. J Bone Joint Surg 103(22):e91CrossRefPubMed Orr MN, Klika AK, Gagnier JJ, Bhandari M, Piuzzi NS (2021) A call for a standardized approach to reporting patient-reported outcome measures: clinical relevance ratio. J Bone Joint Surg 103(22):e91CrossRefPubMed
29.
go back to reference Prodromidis AD, Drosatou C, Mourikis A, Sutton PM, Charalambous CP (2022) Relationship between timing of anterior cruciate ligament reconstruction and chondral injuries: a systematic review and meta-analysis. Am J Sports Med 50:3719–3731CrossRefPubMed Prodromidis AD, Drosatou C, Mourikis A, Sutton PM, Charalambous CP (2022) Relationship between timing of anterior cruciate ligament reconstruction and chondral injuries: a systematic review and meta-analysis. Am J Sports Med 50:3719–3731CrossRefPubMed
31.
go back to reference Salesky MA, Oeding JF, Zhang AL, Ma CB, Feeley BT, Lansdown DA (2021) Patients aged 50 years and older have greater complication rates after anterior cruciate ligament reconstruction: a large database study. Arthrosc Sports Med Rehabil 3:e1827–e1834CrossRefPubMedPubMedCentral Salesky MA, Oeding JF, Zhang AL, Ma CB, Feeley BT, Lansdown DA (2021) Patients aged 50 years and older have greater complication rates after anterior cruciate ligament reconstruction: a large database study. Arthrosc Sports Med Rehabil 3:e1827–e1834CrossRefPubMedPubMedCentral
32.
go back to reference Salzler MJ, Chang J, Richmond J (2018) Management of anterior cruciate ligament injuries in adults aged >40 years. J Am Acad Orthop Surg 26:553–561CrossRefPubMed Salzler MJ, Chang J, Richmond J (2018) Management of anterior cruciate ligament injuries in adults aged >40 years. J Am Acad Orthop Surg 26:553–561CrossRefPubMed
33.
34.
go back to reference Spindler KP, Huston LJ, Chagin KM, Kattan MW, Reinke EK, Amendola A et al (2018) Ten-year outcomes and risk factors after anterior cruciate ligament reconstruction: a MOON longitudinal prospective cohort study. Am J Sports Med 46:815–825CrossRefPubMed Spindler KP, Huston LJ, Chagin KM, Kattan MW, Reinke EK, Amendola A et al (2018) Ten-year outcomes and risk factors after anterior cruciate ligament reconstruction: a MOON longitudinal prospective cohort study. Am J Sports Med 46:815–825CrossRefPubMed
35.
go back to reference Stone JA, Perrone GS, Nezwek TA, Cui Q, Vlad SC, Richmond JC et al (2019) Delayed ACL reconstruction in patients ≥40 years of age is associated with increased risk of medial meniscal injury at 1 year. Am J Sports Med 47:584–589CrossRefPubMed Stone JA, Perrone GS, Nezwek TA, Cui Q, Vlad SC, Richmond JC et al (2019) Delayed ACL reconstruction in patients ≥40 years of age is associated with increased risk of medial meniscal injury at 1 year. Am J Sports Med 47:584–589CrossRefPubMed
37.
go back to reference Sylvia SM, Perrone GS, Stone JA, Miltenberg B, Nezwek TA, Zhang Y et al (2022) The majority of patients aged 40 and older having allograft anterior cruciate ligament reconstruction achieve a patient acceptable symptomatic state. Arthroscopy 38:1537–1543CrossRefPubMed Sylvia SM, Perrone GS, Stone JA, Miltenberg B, Nezwek TA, Zhang Y et al (2022) The majority of patients aged 40 and older having allograft anterior cruciate ligament reconstruction achieve a patient acceptable symptomatic state. Arthroscopy 38:1537–1543CrossRefPubMed
38.
go back to reference Tan CW, Hsu WH, Yu PA, Chen CL, Kuo LT, Chi CC et al (2020) Anterior cruciate ligament reconstruction in patients older than 50 years: a systematic review and meta-analysis. Orthop J Sports Med 8:2325967120915698CrossRefPubMedPubMedCentral Tan CW, Hsu WH, Yu PA, Chen CL, Kuo LT, Chi CC et al (2020) Anterior cruciate ligament reconstruction in patients older than 50 years: a systematic review and meta-analysis. Orthop J Sports Med 8:2325967120915698CrossRefPubMedPubMedCentral
39.
go back to reference Trojani C, Sané JC, Coste JS, Boileau P (2009) Four-strand hamstring tendon autograft for ACL reconstruction in patients aged 50 years or older. Orthop Traumatol Surg Res 95:22–27CrossRefPubMed Trojani C, Sané JC, Coste JS, Boileau P (2009) Four-strand hamstring tendon autograft for ACL reconstruction in patients aged 50 years or older. Orthop Traumatol Surg Res 95:22–27CrossRefPubMed
40.
go back to reference van der Wal WA, Meijer DT, Hoogeslag RAG, LaPrade RF (2022) Meniscal tears, posterolateral and posteromedial corner injuries, increased coronal plane, and increased sagittal plane tibial slope all influence anterior cruciate ligament-related knee kinematics and increase forces on the native and reconstructed anterior cruciate ligament: a systematic review of cadaveric studies. Arthroscopy 38:1664-1688.e1661CrossRefPubMed van der Wal WA, Meijer DT, Hoogeslag RAG, LaPrade RF (2022) Meniscal tears, posterolateral and posteromedial corner injuries, increased coronal plane, and increased sagittal plane tibial slope all influence anterior cruciate ligament-related knee kinematics and increase forces on the native and reconstructed anterior cruciate ligament: a systematic review of cadaveric studies. Arthroscopy 38:1664-1688.e1661CrossRefPubMed
41.
go back to reference Weng CJ, Yang CP, Yeh WL, Hsu KY, Chang SS, Chiu CH et al (2022) Outcomes of anterior cruciate ligament reconstruction in patients older than 50 years and younger than 30 years. Orthop J Sports Med DOI 10:23259671221094788 Weng CJ, Yang CP, Yeh WL, Hsu KY, Chang SS, Chiu CH et al (2022) Outcomes of anterior cruciate ligament reconstruction in patients older than 50 years and younger than 30 years. Orthop J Sports Med DOI 10:23259671221094788
42.
go back to reference Zhang Y, Huang W, Yao Z, Ma L, Lin Z, Wang S et al (2016) Anterior cruciate ligament injuries alter the kinematics of knees with or without meniscal deficiency. Am J Sports Med 44:3132–3139CrossRefPubMed Zhang Y, Huang W, Yao Z, Ma L, Lin Z, Wang S et al (2016) Anterior cruciate ligament injuries alter the kinematics of knees with or without meniscal deficiency. Am J Sports Med 44:3132–3139CrossRefPubMed
43.
go back to reference Zysk SP, Refior HJ (2000) Operative or conservative treatment of the acutely torn anterior cruciate ligament in middle-aged patients. A follow-up study of 133 patients between the ages of 40 and 59 years. Arch Orthop Trauma Surg 120:59–64CrossRefPubMed Zysk SP, Refior HJ (2000) Operative or conservative treatment of the acutely torn anterior cruciate ligament in middle-aged patients. A follow-up study of 133 patients between the ages of 40 and 59 years. Arch Orthop Trauma Surg 120:59–64CrossRefPubMed
Metadata
Title
Preoperative factors associated with failure to reach the patient acceptable symptom state after anterior cruciate ligament reconstruction in patients aged 40 and older
Authors
Richard N. Puzzitiello
Stephen M. Sylvia
Gabriel S. Perrone
Jack T. Bragg
John C. Richmond
Matthew J. Salzler
Publication date
22-02-2023
Publisher
Springer Berlin Heidelberg
Published in
Knee Surgery, Sports Traumatology, Arthroscopy / Issue 8/2023
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-023-07334-x

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