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Open Access 01-12-2018 | Research

Prenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism

Authors: Yingying Wu, Fangfang Qi, Dan Song, Zitian He, Zejie Zuo, Yunjie Yang, Qiongliang Liu, Saisai Hu, Xiao Wang, Xiaona Zheng, Junhua Yang, Qunfang Yuan, Juntao Zou, Kaihua Guo, Zhibin Yao

Published in: Journal of Neuroinflammation | Issue 1/2018

Abstract

Background

Prenatal infection is a substantial risk factor for neurodevelopmental disorders such as autism in offspring. We have previously reported that influenza vaccination (VAC) during early pregnancy contributes to neurogenesis and behavioral function in offspring.

Results

Here, we probe the efficacy of VAC pretreatment on autism-like behaviors in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) mouse model. We show that VAC improves abnormal fetal brain cytoarchitecture and lamination, an effect associated with promotion of intermediate progenitor cell differentiation in MIA fetal brain. These beneficial effects are sufficient to prevent social deficits in adult MIA offspring. Furthermore, whole-genome analysis suggests a strong interaction between Ikzf1 (IKAROS family zinc-finger 1) and neuronal differentiation. Intriguingly, VAC rescues excessive microglial Ikzf1 expression and attenuates microglial inflammatory responses in the MIA fetal brain.

Conclusions

Our study implies that a preprocessed influenza vaccination prevents maternal bacterial infection from causing neocortical lamination impairments and autism-related behaviors in offspring.

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Title: Prenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism
Authors: Yingying Wu
Fangfang Qi
Dan Song
Zitian He
Zejie Zuo
Yunjie Yang
Qiongliang Liu
Saisai Hu
Xiao Wang
Xiaona Zheng
Junhua Yang
Qunfang Yuan
Juntao Zou
Kaihua Guo
Zhibin Yao
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Journal of Neuroinflammation / Issue 1/2018
Electronic ISSN: 1742-2094
DOI: https://doi.org/10.1186/s12974-018-1252-z

At a glance: The STEP trials

Springer Medicine

Prenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism

Abstract

Background

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Results

Conclusions

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