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BMC Pregnancy and Childbirth

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Open Access 01-12-2003 | Case report

Prenatal diagnosis of Wolf-Hirschhorn syndrome (4p-) in association with congenital hypospadias and foot deformity

Authors: Halil Aslan, Nilay Karaca, Seher Basaran, Hayri Ermis, Yavuz Ceylan

Published in: BMC Pregnancy and Childbirth | Issue 1/2003

Abstract

Background

Wolf-Hirschhorn syndrome is caused by distal deletion of the short arm of chromosome 4 (4p-). We report a case in which intrauterine growth restriction, hypospadias and foot deformity were detected by prenatal ultrasound examination at 29 weeks of gestation.

Case Presentation

A 31-year-old gravida 2 partus 1 woman was referred at 29 weeks' gestation with suspicion of intrauterine growth restriction. Sonographic examination revealed deformity of the right lower limb and undescended testes with an irregular distal penis. A cordocentesis was performed and chromosome analysis revealed a 46,XY,del(4)(p14) karyotype.

Conclusion

The prenatal detection of intrauterine growth restriction, hypospadias and foot deformity should lead doctors to suspect the presence of Wolf-Hirschhorn syndrome.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2393/3/1/prepub

Title: Prenatal diagnosis of Wolf-Hirschhorn syndrome (4p-) in association with congenital hypospadias and foot deformity
Authors: Halil Aslan
Nilay Karaca
Seher Basaran
Hayri Ermis
Yavuz Ceylan
Publication date: 01-12-2003
Publisher: BioMed Central
Published in: BMC Pregnancy and Childbirth / Issue 1/2003
Electronic ISSN: 1471-2393
DOI: https://doi.org/10.1186/1471-2393-3-1

At a glance: The STEP trials

Springer Medicine

Prenatal diagnosis of Wolf-Hirschhorn syndrome (4p-) in association with congenital hypospadias and foot deformity

Abstract

Background

Case Presentation

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case Presentation

Conclusion

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