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01-12-2021 | Premedication | Brief Report

Asfotase Alfa hypersensitivity: an outpatient 8-steps desensitization protocol

Authors: Stefania Scudu, Alessandra Ghisu, Giulia Costanzo, Maria Pina Barca, Davide Firinu, Stefano Del Giacco

Published in: Immunologic Research | Issue 6/2021

Excerpt

Hypophosphatasia (HPP) is a rare inherited disorder of bone and mineral metabolism, caused by a number of loss-of-function mutations in the ALPL (alkaline phosphatase liver type) gene, with generalized reduction of activity of the tissue-non-specific (liver/bone/kidney) isoenzyme of ALP (TNSALP) [1]. …

Hofmann C, Girschick HJ, Mentrup B, Graser S, Seefried L, Liese J, Jakob F. Clinical aspects of hypophosphatasia: an update. Clin Rev Bone Miner Metab. 2013;11(60–70):5.

Martos-Moreno GA, Calzada J, Couce ML, Argente J. Hipofosfatasia: manifestaciones clínicas, recomendaciones diagnósticas y opciones terapéuticas [Hypophosphatasia: clinical manifestations, diagnostic recommendations and therapeutic options]. An Pediatr (Barc). 2018;88(6):356.e1-356.e11. https://doi.org/10.1016/j.anpedi.2017.06.004.CrossRef

European Medicines Agency, Science Medicines Health, EMA/716209/2018; EMEA/H/C/003794.

Whyte MP, Madson KL, Phillips D, Reeves AL, McAlister WH, Yakimoski A, et al. Asfotase Alfa therapy for children with hypophosphatasia. JCI Insight. 2016;1:e85971.CrossRef

Bianchi ML, Bishop NJ, Guañabens N, et al. Hypophosphatasia in adolescents and adults: overview of diagnosis and treatment. Osteoporos Int. 2020;31(8):1445–60.CrossRef

Hong D. Desensitization for allergic reaction chemotherapy. Yonsei Med J. 2019;60(2):119–25.CrossRef

Castells MC. Mass-a new era for drug desensitizations. J Allergy Clin Immunol Pact. 2015;3:639-40.2213-2198.CrossRef

AIFA 2020 scheda tecnica del farmaco Strensiq 23 maggio. 2020.

Castells Mc. Guitart-Rapid drug desensitization for hypersensitivity reactions to chemotherapy and monoclonal antibodies in the 21st century. J Investig Allergol Clin Immunol. 2014;24(2):72–9.

10.

Makimoto G, Nishi T, Kaxakado K, Nishimura T, Tamura T, Kudo K, Kuyama S. Successful desensitization treatment with osimertinib after the development of osimertinib-induced urticaria in a patient undergoing treatment for a non-small cell lung cancer Harboring the EGFR T790M mutation: a case report. https://doi.org/10.2169/internalmedicine.4429-20.

Title: Asfotase Alfa hypersensitivity: an outpatient 8-steps desensitization protocol
Authors: Stefania Scudu
Alessandra Ghisu
Giulia Costanzo
Maria Pina Barca
Davide Firinu
Stefano Del Giacco
Publication date: 01-12-2021
Publisher: Springer US
Keywords: Premedication
Hypophosphatasia
Published in: Immunologic Research / Issue 6/2021
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-021-09232-1

At a glance: The ONWARDS insulin icodec trials

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Asfotase Alfa hypersensitivity: an outpatient 8-steps desensitization protocol

Excerpt

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Excerpt

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