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Journal of Assisted Reproduction and Genetics

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31-01-2024 | Preimplantation Genetic Diagnostics | Assisted Reproduction Technologies

Correlation of self-reported racial background to euploidy status and live birth rates in assisted reproductive technology cycles

Authors: Tamar Alkon-Meadows, Carlos Hernandez-Nieto, Tia Jackson-Bey, Teresa A. Cacchione, Joseph Lee, Martha Luna-Rojas, Dmitry Gounko, Alan Copperman, Erkan Buyuk

Published in: Journal of Assisted Reproduction and Genetics | Issue 3/2024

Abstract

Purpose

To determine whether the embryonic euploidy rate and live birth outcomes following single, euploid embryo transfer (SEET) differ among women of self-reported racial and ethnic backgrounds.

Methods

This retrospective cohort study included all infertile patients of different self-reported racial backgrounds who underwent In vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) and an autologous single euploid embryo transfer (SEET) from December 2015 to December 2019 at a single private and academic assisted reproduction technology center. Primary outcome measures included ploidy rates among different racial groups. Secondary outcomes included clinical pregnancy, clinical pregnancy loss, and live birth rates.

Results

Five thousand five hundred sixty-two patients who underwent an IVF cycle with ICSI-PGT-A were included. A total of 24,491 blastocysts were analyzed. White participants had on average more euploid embryos and higher euploidy rates when compared to their counterparts (p ≤ 0.0001). However, after controlling for confounding factors, there was no association between race and the odds of having a higher euploidy rate (aOR 1.31; 95% CI 0.63–2.17, p = 0.42). A total of 4949 patients underwent SEET. Pregnancy outcomes did not differ among patients of varying self-reported races.

Conclusions

Euploidy rates and pregnancy outcomes were comparable among patients of different racial backgrounds who underwent a SEET.

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Title: Correlation of self-reported racial background to euploidy status and live birth rates in assisted reproductive technology cycles
Authors: Tamar Alkon-Meadows
Carlos Hernandez-Nieto
Tia Jackson-Bey
Teresa A. Cacchione
Joseph Lee
Martha Luna-Rojas
Dmitry Gounko
Alan Copperman
Erkan Buyuk
Publication date: 31-01-2024
Publisher: Springer US
Keywords: Preimplantation Genetic Diagnostics
Infertility
Infertility
Published in: Journal of Assisted Reproduction and Genetics / Issue 3/2024
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-024-03039-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Correlation of self-reported racial background to euploidy status and live birth rates in assisted reproductive technology cycles

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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